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Biomedical subjects

A E Stocks

Publications and source records attributed to A E Stocks.

At least 19 recordsLinked to original sources
PubMed2000

Lend me your ears...

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Blood Glucose Self-Monitoring↗
PubMed1999

Insulin lispro: experience in a private practice setting.

OBJECTIVE: To assess the benefits (or otherwise) of changing patients with unstable type 1 diabetes to insulin lispro (Humalog, Aza Research). PARTICIPANTS AND SETTING: 150 patients with type 1 diabetes treated in a private metropolitan physician practice. MAIN OUTCOME MEASURES: Glycohaemoglobin (%HbA1c) value; frequency of hypoglycaemia; patients' perceptions of the two regimens. RESULTS: 125 of 150 patients completed the study; 12 (8%) withdrew because they were dissatisfied with lispro. Including these 12 patients, 80/137 patients (58%) felt better physically and 98 (72%) were more satisfied with treatment with lispro. Of the 125 patients who completed the study, 65 (52%) achieved lower HbA1c values, with 22 (18%) experiencing a fall of 1% or more; 78 patients (62%) noted less daytime hypoglycaemia and 103 (82%) experienced less nocturnal hypoglycaemia. Thirty-nine patients (31%) with less daytime hypoglycaemia and 52 (42%) with less nocturnal hypoglycaemia also experienced a fall of more than 0.2% in HbA1c value (mean, 1.0%; range, 0.3%-3.2%). There was no change in body weight or in hypoglycaemia unawareness. CONCLUSION: Many patients with unstable type 1 diabetes, when changed to insulin lispro, experience significant clinical and biochemical benefits.

Adolescent↗
PubMed1996

Analysis of risk factors for neuropathic foot ulceration in diabetes mellitus.

Diabetes mellitus affects about one in 25 Australians. Neuropathic foot ulceration is a frequent complication in persons with diabetes. This study evaluates the importance of different risk factors for the development of this condition. The role of nonenzymatic glycosylation and pressure beneath the sole of the foot in the pathogenesis of neuropathic foot ulcers was investigated. Twenty-seven subjects with diabetes with a recent history of neuropathic foot ulceration were matched by age and sex with a group of 50 control subjects without neuropathy or history of foot ulceration. The degree of nonenzymatic glycosylation was assessed by analyzing the average level of glycosylated hemoglobin in the 3 years prior to the development of the foot ulcer and a goniometer assessment of peripheral joint (hand and ankle) flexibility. Dynamic pressure of the plantar aspect of the foot was recorded using a Musgrave Footprint System pedobarograph during a normal gait cycle. There was no significant difference in age, sex, body mass index, and duration or type of diabetes between the ulcer and control groups. The pressure of the plantar aspect of the foot was significantly elevated (p < 0.01). Ankle joint flexibility was reduced (p < 0.01) in cases with neuropathic foot ulceration compared with the control group. There was a trend toward elevation of glycosylated hemoglobin (HbA1c fraction) or HbA1c in the ulcer group (p = 0.06). The results suggested that nonenzymatic glycosylation occurs at a more significant level in patients with diabetes with a history of neuropathic foot ulceration.

Aged↗
PubMed1991

Human insulin.

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Diabetes Mellitus, Type 1↗
PubMed1988

Lack of effect of glibenclamide on insulin requirements and diabetic control in persons with insulin-dependent diabetes.

The addition of the sulphonylurea agent, glibenclamide, to the insulin therapy of six patients with insulin-dependent diabetes mellitus was studied in a double-blind cross-over trial. The subjects produced no measurable plasma C-peptide after stimulation with glucagon, weighed within 10% of their ideal body weight and required approximately 1 U/kg per day of insulin. After one month of close supervision while the patients were being managed with diet and insulin therapy alone, glibenclamide, three times a day, or a placebo, was added to the therapy for one month. After a further one-month control period, the alternate agent was administered for one month. No change in the insulin requirement or the glycosylated haemoglobin levels, or in the 24-hour profiles of the plasma glucose and free insulin levels in response to a standard diet, was observed at the end of each treatment period. This study suggests that any enhancement of insulin sensitivity by sulphonylurea treatment in persons with insulin-dependent diabetes mellitus is only minor and clinically-unimportant.

Adult↗
PubMed1987

Hypothalamic/pituitary sarcoidosis.

A patient is described with combined pulmonary and central nervous system sarcoidosis, including hypothalamic/pituitary involvement. Formal pituitary challenge testing was performed before steroid treatment and again eight months later. Diabetes insipidus, hyperprolactinemia, and anterior pituitary hormone deficiencies were demonstrated and did not improve significantly in response to steroids. Hypothalamic/pituitary involvement is a rare complication of sarcoidosis, the incidence of which may be under-reported.

Adult↗
PubMed1986

Hypercalcaemia. The case of the missing adenoma.

A case of severe hypercalcaemia is described. The biochemical picture strongly suggested primary hyperparathyroidism, yet no adenoma could be found in the neck or upper mediastinum. The tumour was eventually demonstrated by computerized tomographic scan and was removed at surgery from the posterior mediastinum beneath the arch of the aorta. Preoperative and postoperative problems of the case are discussed.

Acute Disease↗
PubMed1980

Cis-platinum treatment of metastatic adrenal carcinoma.

Cis-platinum was used in the management of four patients with metastatic carcinoma of the adrenal cortex. In each instance, clinical and objective response was observed. This agent would appear to warrant further trial in the management of this rare tumour.

Abdominal Neoplasms↗
PubMed1978

Testicular damage due to cytotoxic drugs and recovery after cessation of therapy.

Testicular function was assessed in 32 patients who received standard chemotherapy regimens for disseminated lymphomas. Thirty-one had evidence of germ cell damage, as assessed by the finding of azoospermia and/or high plasma levels of follicle-stimulating hormone (FSH). In addition, five patients had persistently low plasma testosterone levels associated in three with elevated plasma luteinising hormone (LH) levels. Reproductive function did not recover in any patient while chemotherapy continued. Cessation of therapy was possible in 16 patients with prolonged remissions of disease. Among these, recovery of germinal epithelium differed greatly between the cyclophosphamide / vincristine / prednisone treated group and the mustine/procarbazine/vincristine/prednisone treated group. Seventy per cent of the former patients had evidence of recovery after 34 months of follow-up while only one (17%) of the latter had begun to recover at 52 months post-therapy. Serial measurement of plasma FSH levels proved useful in predicting likely recovery of spermatogenesis.

Adolescent↗
PubMed1977

Is obesity an endocrine condition?

Obesity is an extremely common condition, affecting one-third of the adult population of Australia. In the great majority of cases, the problem is due to calorie imbalance resulting from an excessive food intake coupled with inadequate exercise. Endocrine causes of obesity are relatively uncommon, but should be excluded in every case. This article compares the clinical features of primary obesity and endocrine obesity, and outlines the investigations which may be used to exclude endocrine causes for obesity.

Cushing Syndrome↗
PubMed1976

Principles of management of juvenile-onset diabetes.

This paper discusses "juvenile-onset diabetes", which is a condition that can begin at any time during the life span. The condition is understood to mean that type of diabetes in which there is absolute insulin deficiency, and where insulin therapy is required.

Adolescent↗
PubMed1969

Insulin sensitivity and vascular disease in maturity-onset diabetics.

In 27 maturity-onset diabetics of more than 10 years' duration there was a significant tendency for both atherosclerosis and microangiopathy to be associated with a reduction in the acute hypoglycaemic effect of intravenous beef insulin. This finding is identical to that in a group of 51 insulin-dependent diabetics previously reported.It is suggested that insulin insensitivity probably precedes the appearance of vascular disease in diabetes and may be implicated in its production.

Aged↗