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Biomedical subjects

A E Read

Publications and source records attributed to A E Read.

At least 163 records · Page 9Linked to original sources
PubMed1970

A case of small-intestinal mucosal atrophy.

A patient is described with a severe malabsorption syndrome which failed to respond to a gluten-free diet. Although subtotal villous atrophy was present in the jejunal mucosa, histological features of subepithelial fibrosis and apparently normal enterocytes were not suggestive of coeliac disease. The findings of decreased mucosal thickness, of a normal mitotic rate in the crypt cell population, and of the decreased rate of loss of epithelial cells further suggested that the disease process producing the ;flat' mucosa was not that of coeliac disease. The condition was complicated by ileal ulceration and active tuberculosis.

Atrophy↗
PubMed1969

Gall stones in patients with disorders of the terminal ileum and disturbed bile salt metabolism.

In a combined historical and radiological survey gall stones were found in 23 out of 72 patients with disorders of the terminal ileum (31.9%). This is four to five times the expected incidence of cholelithiasis. In these patients the incidence of gall stones was not related to age, but did, however, increase with increased duration of the ileal disorder. Glycine/taurine conjugation ratios of bile salts in the bile were abnormally high in 10 out of 11 patients with ileal disorders. Both impaired bile salt recirculation and absorption of poorly soluble bacterially degraded bile salts are possible causes of cholelithiasis in these patients.

Adult↗
PubMed1969

Effects of chlorpromazine in patients with hepatic disease.

Patients with cirrhosis were found to be extremely sensitive to chlorpromazine as shown by slowing of the electroencephalograph (E.E.G.), which was particularly definite in those who had had hepatic encephalopathy previously. Patients showing the most definite E.E.G. changes were in general very sleepy and took some hours to recover after taking chlorpromazine. It is concluded that phenothiazine drugs should be used very cautiously in patients with alcoholic liver disease.

Ammonia↗
PubMed1969

The use of ultrasound in the diagnosis of cystic lesions of the liver and upper abdomen and in the detection of ascites.

The use of ultrasonic A- and B-scans has been evaluated in the diagnosis of fluid-filled lesions in the liver and abdomen, and in the detection of intraperitoneal fluid. Six patients with polycystic livers or suspected polycystic livers, three with solitary cysts, four with liver abscesses, and three with miscellaneous intraabdominal cystic lesions were scanned. The lesions could be clearly distinguished from solid masses by either technique. The presence of as little as 300 to 800 ml of intraperitoneal fluid could be detected by either the A- or B-scan.

Adult↗
PubMed1969

An isotope technique for measuring lactose absorption.

Expired radiocarbon dioxide has been collected by a simple autotitration method following the ingestion of lactose-1-(14)C. With this method, which is suitable for clinical use, 12 subjects with alactasia have been readily separated from 24 normals, both groups being defined by strict criteria. This test, which may be used to measure the absorption of other sugars, is especially suitable for population surveys and may be used to investigate the distribution of disaccharidase deficiency.A further advantage is that false low readings resulting from rapid plasma clearance of absorbed sugar do not occur with this method although they may do so in up to one in three lactose tolerance tests, thereby overestimating the prevalence of alactasia.

Adult↗