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Biomedical subjects

A E Read

Publications and source records attributed to A E Read.

186 records · Page 11Linked to original sources
PubMed1966

Plasma lactate dehydrogenase in megaloblastic anaemia.

Raised plasma lactate dehydrogenase (LDH) values were found in 26 patients with marked megaloblastic anaemia due either to vitamin B(12) or folic-acid deficiency or a combination of these factors.Minor megaloblastic changes were not usually accompanied by plasma LDH elevation. Serial LDH estimations were as valuable as serial reticulocyte counts in assessing the response to physiological doses of folic acid and therefore in deciding whether megaloblastic anaemia is partially or completely due to folic acid deficiency.

Anemia, Macrocytic↗
PubMed1966

Howell-Jolly bodies in idiopathic steatorrhoea.

Large numbers of Howell-Jolly bodies were found in the bone marrow and peripheral blood, both before and after corrective haematinic therapy, in three patients with idiopathic steatorrhoea with associated splenic atrophy, who presented with megaloblastic anaemia. The proportion of erythrocytes containing Howell-Jolly bodies was much higher in these patients when compared with the number found in post-splenectomy subjects. Red cell survival studies of patients' own red cells, sensitized with a potent anti-D serum, showed an abnormally prolonged survival in the three patients with splenic atrophy when compared with those in two splenectomized subjects, in four patients with coeliac disease, and in seven normal controls. There appears to be a relationship between atrophy of the reticuloendothelial system and Howell-Jolly body production in idiopathic steatorrhoea.

Adult↗