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Biomedical subjects

A E Pashchenko

Publications and source records attributed to A E Pashchenko.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Thyroid function in persons with hyperplasia of the thyroid gland in the presence of iodine deficiency].

The levels of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (RT3), thyroxine-binding capacity (TBC), a free thyroxine index (FT4I) and thyroid-stimulating hormone (TSH) were studied by a radioimmunoassay in the blood of healthy schoolchildren aged 14 to 17 with stage I-II of thyroid hyperplasia residing in a mountain region of the Transcarpathian area, the Ukrainian SSR, with noticeable environmental iodine deficiency. Similar studies were conducted in a lowland region with a sufficient iodine level. A decrease in the concentration of T4, T3, RT3 and FT4I and higher TBC and TSH values were established in the healthy schoolchildren from the mountain region as compared to corresponding values in the schoolchildren from the lowland region indicating a lower level of homeostasis of thyroid hormones in the mountain region. A decrease in indices of thyroid function was observed in hyperplasia as compared to indices of the healthy, schoolchildren (T3 and TSH levels were higher) both in the mountain and lowland regions. More pronounced shifts were revealed in the blood of the schoolchildren from the mountain region. Less iodine was excreted with daily urine in the healthy schoolchildren from the mountain region than in the schoolchildren from the lowland region. Schoolchildren with hyperplasia excreted less iodine than healthy children, iodine excretion being lower in the schoolchildren from the mountain region. The results obtained suggested the hypothyroid nature of thyroid hyperplasia in the mountain region. The importance of iodine prophylaxis was emphasized.

Adolescent↗
PubMedDate not supplied

[Middle molecule fraction in the serum of rats with toxic hepatitis].

An increase in the amount of the middle molecular peptide (MM) fraction in the blood serum of rats with experimental toxic hepatitis and normalization of the MM pool after the administration of the amino acid mixture Alvesin "Novy" are shown. The chromatographic spectra of the MM fraction in normal and experimental animals are compared.

Amino Acids↗
PubMedDate not supplied

[Functional activity of the thyroid gland and distribution of its hormones in peripheral tissues under experimental liver disease].

Experimental acute toxic hepatitis causes functional reconstruction of the thyroid gland accompanied by intensified levels of total iodine and its hormonal compounds in blood. In most of non-thyroid tissues a decrease in the total and hormonal iodine content is revealed, but in kidneys these indices are considerably higher. The level of the nonhormonal iodine compounds in blood and tissues under study does not essentially vary and only in the liver, heart and lungs the expressed lowering of inorganic iodides is observed.

Animals↗
PubMedDate not supplied

[Free amino acids in the brain of vertebrates].

Studies have been made on the content of free amino acids in the brain of the pike Esox lucius, frog Rana ridibunda, pheasant Phasinus colhidus, hare Lepus europaeus, as well as their distribution in the white and grey matter of healthy human subjects. Differences in the distribution of free amino acid pool were found between man and animals. In the grey matter of human brain, large quantities of free ornithine, phenylalanine, lysine, serine, glycine, alanine, tyrosine, tryptophan, methionine, leucine and isoleucine, as well as lower level of aspartic acid, glutamic acid and threonine were found as compared to the white matter. The content of ornithine, serine and threonine increases in the row birds greater than fishes greater than man greater than mammals greater than amphibians; histidine and arginine pool increases in the following sequence: birds greater than fishes greater than mammals greater than amphibians greater than man.

Adult↗
PubMedDate not supplied

[Free amino acids in brain tissue and its subcellular structures in hyperthermia in rats].

Free amino acids reserves in the brain tissue, nuclei and mitochondria were investigated in mongrel albino rats under conditions of hyperthermia (45 degrees C) of different duration--7,20 and 60 min. It was found that reserves of most free amino acids in the albino rat brain decreased under a short-term (7 min) hyperthermia and accumulated under more prolonged (20-60 min) one. The amount of amino acids in the brain mitochondria increased 7 min after the experiment start and decreased 20 min later, then (60 min later) the amount of most amino acids increased considerably. Opposite shifts were detected in the content of most amino acids in nuclei.

Amino Acids↗
PubMedDate not supplied

[Dynamics of free amino acids in rat brain tissue during hypothermia].

A comparative study is conducted for the effect of one-, three- and six-hour artificial deep (20-19 degrees C) hypothermia on the content of free amino acids in the blood serum, tissue, nuclei and mitochondria of the rat brain. It is found out that the content is the highest in the blood serum after a three-hour cooling. In the brain tissue the amount of amino acids lowers, especially under conditions of a six-hour hypothermia. In nuclei a three-hour effect of hypothermia decreases sharply the content of free amino acids and the six-hour one increases the amount of most of them. Under hypothermia the content of nearly all amino acids in the brain mitochondria is higher than in the intact animals.

Amino Acids↗
PubMedDate not supplied

[Distribution of free amino acids in the rat brain during ontogenesis].

Distribution of free amino acids reserves in the brain tissues, nuclei and mitochondria of rats is studied in ontogenesis dynamics. It is established that the content of most amino acids in tissues and mitochondria increases by the 6-month age, lowers in the brain tissues and subcellular structures by the 12-month age, decreases in the tissues and nuclei and grows in mitochondria of old animals. The reasons of disbalance in distribution of the reserves of free amino acids are under discussion.

Aging↗
PubMedDate not supplied

[Age characteristics of glycolipid distribution in rat tissues depending on the functional state of the thyroid gland].

Distribution of the content of cerebrosides in the rat tissues is established to be nonuniform for the series brain greater than spleen greater than lungs greater than liver greater than kidneys greater than heart greater than muscles. In the new born animals only traces of cerebrosides and considerable amounts of gangliosides are found. In the process of the morphological and functional maturing all the tissues get enriched by cerebrosides (till 45 days) and gangliosides (by 15 days) with their content decrease in certain tissues in the process of ageing. Experimental hypothyrosis is accompanied by a fall of the total content and a decrease in the amount of hormonal iodine in the tissues, the decrease being more significant in young animals. The age dynamics of the glycolipid content inthe tissues is maintained, but their highest accumulation is delayed and does not reach the maximum characteristics of the intact animals.

Animals↗