[Narcotic analgesics. Part IV. Agonists-antagonists and total antagonists of opiate receptors. Perspectives for clinical use of narcotic analgesics].
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Biomedical subjects
Publications and source records attributed to A E Dubitskiĭ.
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The three groups of patients who had morphine hydrochloride, phentanyl and dipidolor been used for intravenous autoanalgesia were examined. In each group, the state of the central hemodynamics, pulmonary ventilation and gas composition of the blood were studied. The effectiveness of analgesia was assessed, side effects were considered. The effectiveness of the use for postoperative intravenous autoanalgesia of morphine and phentanyl has been proved.
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In 30 patients with IIA-IIB stage hypertension operated on for cholelithiasis, gastric and duodenal ulcer disease and other diseases, clophelinum was used as a component of total intravenous anesthesia. The different methods of its administration were assessed. The optimal variant of hemodynamic stabilization was noted in programmed clophelinum administration by means of infusator "Vita-beta" at a dose of 0.75 g/(kg.hr).
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Gel electrophoresis was used to study the blood serum of 13 patients with insulinomas who showed marked dysproteinemia in the preoperative period. Enucleation of the tumour or resection of the pancreas were performed depending on the location of the tumours. In the immediate postoperative period dysproteinemia became more pronounced, then a tendency to normalization of the protein spectrum occurred. Dysproteinemia was most pronounced at the zone of the starting peak where insulin-binding proteins are located.
Enteral administration of pancreatic juice in 17 patients after pancreatoduodenal resection caused a decrease in the activity of trypsin, amylase and lipase, pancreatic lipase and trypsin of the pancreatic juice in the blood. The increase in the level of insulin in the blood was noted. The mentioned method can be used for prevention of the development of postoperative pancreatogenic complications.
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Direct thermometry of the pancreas in 44 patients after operations for carcinoma of the pancreato-duodenal zone or chronic pancreatitis has shown a relationship between temperature of the pancreas stump and the fermentemia degree. Characteristic changes of temperature regimens are observed 5-17 hours earlier than manifestations of clinical symptoms of postoperative pancreatitis make their appearance.
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