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Biomedical subjects

A E Anderson

Publications and source records attributed to A E Anderson.

At least 55 records · Page 3Linked to original sources
PubMed1982

Affixment arrangements of peribronchiolar alveoli in normal and emphysematous lungs.

Our investigation of the radially affixed alveoli of nonrespiratory bronchioles showed that the interalveolar interval was basically constant for normal bronchioles of all sizes, with a mean value of 0.146 mm. The mean interalveolar interval increased significantly to 0.173 and 0.209 mm, respectively, in the two most severe grades of emphysema. The pattern of alveolar affixment to the walls of bronchioles was also altered in emphysema, with irregular interruptions, variations in size and shape of abutting luminal spaces, and loss of alveolar attachment surface. These changes reflected the disruptive phase of emphysema and corroborated previous studies. A dominant extrinsic force normally responsible for bronchiolar patency is thus compromised. Any bronchiole so affected would logically be prone to collapse or contracture of its wall, luminal deformities, diminution of luminal caliber, and retarded airflow.

Autopsy↗
PubMed1981

Smoking, mortality, and six in a community hospital necropsy population.

Analysis of 344 necropsies at a community hospital disclosed a male to female ratio of 1.9:10 and a smoking incidence over twice that of the general population. Overall longevity for men was less than for women. Intragroup comparisons showed an inverse relationship between smoking and longevity. Smokers in general and subsets of male and female smokers thus died earlier than respective nonsmokers. Trends for nonsmoking men and women were not different. However, smoking women surprisingly died earlier than smoking men at comparable pack-year exposure levels. Conversely, nonsmokers were most likely to achieve old age with freedom from diseases usually associated with smoking. We conclude that smoking predisposes to hospitalization, with premature death. Men suffer the most, probably because of traditionally heavier usage. For reasons unclear, however, women who do smoke may exhibit excessive vulnerability in some situations.

Aged↗
PubMed1980

Legal abortions and trends in fetal and infant mortality rates in the United States.

Using states as the units for analysis, we found no evidence that during the early 1970s in the United States the legalization of abortions influenced trends in infant mortality rates. If fetal deaths were reduced by legal abortions during that period then the influence was modest and brief. These conclusions differ substantially from all earlier studies of the relationship between legal abortions and pregnancy outcomes in the United States which examined trends in areas with many legal abortions while ignoring areas with relatively few legal abortions.

Abortion, Legal↗
PubMed1979

Pharmacokinetics and pharmacodynamic studies of labetalol in hypertensive subjects.

1 The pharmacokinetics of labetalol were studied in twelve hypertensive patients, ten of whom were not receiving other therapy. 2 Following intravenous administration there was a three- to fourfold variation in terminal elimination half-life, volume of distribution and total plasma clearance. The mean elimination half-life was 3.25 hours. 3 Following oral administration the drug was absorbed rapidly. Systemic availability varied from 11-86% (mean 33%). 4 Plasma levels correlated poorly with the acute effect on BP, raising the possibility of labetalol acting in a deep tissue compartment or alternatively an active metabolite contributing to its effect.

Administration, Oral↗
PubMed1977

Further observations on luminal deformity and stenosis of nonrespiratory bronchioles in pulmonary emphysema.

In an endeavour to elucidate the anatomical basis for the increased resistance to airflow which characterises the most peripheral conducting air passages in pulmonary emphysema, lumina of nonrespiratory bronchioles of lungs with mainly centrilobular disease were assessed for two- and three-dimensional features by: (1) determination of percentage conformity of the lumina of individual bronchioles in histological sections to hypothetical planes through cylinders (ie, ellipses with the same areas and circumferences), and (2) comparison of luminal areas at regular intervals along bronchiolar longitudinal axes. The lumina of most nonrespiratory bronchioles from normal lungs conformed closely to their respective ellipses, thus corroborating previous observations that they are normally cylindroid. In contrast, there was a substantial excess of plane section deformities in the lumina of nonrespiratory bronchioles from the emphysematous specimens. The incidence of stenotic bronchioles (by both diameter and area determinations) was also greatly increased in emphysema. Since there was a strong positive association between such stenotic lesions and bronchiolar deformity, the latter was concluded to be a major factor in bronchiolar restriction. Furthermore, these characteristics seemed to have three-dimensional expression, for the lumina of stenotic bronchioles in emphysema were irregular in a longitudinal fashion.

Bronchi↗
PubMed1974

Cardiac trauma: Clinical and experimental correlations of myocardial contusion.

Clinical and experimental observations in myocardial contusion have been correlated. Cardiac arrhythmia is always an important consequence and may be fatal. Reduction in cardiac output often accompanies significant cardiac injury. The coronary arterial circulation is not interrupted and is generally enhanced to the area of injury. Healing of the injury under these circulatory conditions may result in patchy scarring and peculiar adynamic areas of myocardium. Early diagnosis of myocardial contusion may be aided using radionuclide imaging with (99m)Tc-Sn-polyphosphate.

Adult↗