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Biomedical subjects

A Dyas

Publications and source records attributed to A Dyas.

21 records · Page 2Linked to original sources
PubMed1983

Ozone killing action against bacterial and fungal species; microbiological testing of a domestic ozone generator.

The action of ozone generated from a small domestic device was examined with a view to using it in clinical isolation units accommodating immunosuppressed patients. Over a six-hour period in an average size room the device did not generate sufficient ozone to suppress bacterial and fungal growth. A useful bactericidal action, against a variety of human pathogens was achieved with ozone concentrations between 0.3 to 0.9 ppm. Bactericidal ozone concentrations are close to the limit permitted for human exposure however and further experiments are indicated.

Bacteria↗
PubMed1982

Pharmacokinetics and tissue penetration of azthreonam.

Six healthy male volunteers received 1 g of azthreonam each as an intravenous injection. Serial blood and cantharides-induced blister fluid samples were taken over the next 8 h. Urine samples were collected over 24 h. The concentration of azthreonam in serum was about 50 micrograms/ml at 0.5 h after injection and fell to 2 to 3 micrograms/ml at 8 h; the serum half-life was 1.93 h, and the volume of distribution was equivalent to 12% of the mean body weight. The plasma clearance was 89.0 ml/min, 73.7% of the dose being recovered in the urine within 24 h. Azthreonam rapidly penetrated blister fluid, reaching a maximum of 25.4 micrograms/ml at 1.8 h after administration.

Adult↗