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Biomedical subjects

A Dupont

Publications and source records attributed to A Dupont.

At least 379 records · Page 21Linked to original sources
PubMedDate not supplied

Antibody prevalence against haemorrhagic fever viruses in randomized representative Central African populations.

Between 1985 and 1987, 5,070 randomly selected persons living in 6 central African countries (Cameroon, Central African Republic, Chad, Congo, Equatorial Guinea and Gabon) were checked for serological evidence of haemorrhagic fever. Rural and urban areas were studied, including ecoclimatic zones ranging from dry savana to tropical rain forest. Virus-reactive antibodies were found with all antigens tested, and the global prevalence of positive sera was distributed as follows: Crimean-Congo haemorrhagic fever virus, 0.22%; Rift Valley fever virus, 0.18%; Ebola virus, 12.40%; Marburg virus, 0.39%; Lassa virus, 0.06%; and Hantaan virus, 6.15%. A significant variation in antibody prevalence was observed within the study regions. Association between the viruses was not observed.

Africa, Central↗
PubMedDate not supplied

[Contribution of proteomic analysis to study cardiovascular physiopathology].

Proteomic is an innovative approach for determining without any priori the coordinated changes in protein levels contained in a biological sample. This technique now constitutes a powerful tool for revealing, in particular by differential analysis, biological responses and regulation of proteins. This field is becoming essential in each domain for fundamental and clinical biology, mainly in human medicine. It leads to improve the understanding of complex physiopathological processes like those involved in human pathologies, but also for identifying new biomarkers in order to consider new diagnostic and prognostic approaches and original therapeutic targets. The different proteomic techniques, essentially bi-dimensional electrophoresis and mass spectrometry, which benefit from recent technological developments, are presented in this article. A literature review summarize data obtained from proteomic works performed to have better understanding of mechanisms involved in cardiovascular diseases, first cause of morbidity and mortality in the world. Proteomic analysis performed in this area of research are promising, because of the lack of knowledge in the molecular interactions and the complexity of mechanisms involved, and of the impact of environmental risk factors. This impact is being generally only detectable at protein level. These works are only at the beginning and these approaches applied in cardiovascular field will meet a large success in the immediate future and should be promising.

Cardiovascular Diseases↗
PubMedDate not supplied

[Non-chromaffin laryngeal paraganglioma. Clinical and electron microscopical study].

The authors describe the case of a 51 year-old woman presenting with a very large laryngeal paraganglioma in the aryepiglottic fold which had passed through the cricothyroid membrane and invaled the thyroid. A crico-hyoido-pexy enabled the tumour to by completely removed and anatomo-pathological examination showed degeneration. Under electron microscopy, the ultrastructure of the tumour was similar to that of chromaffin paragangliomas. It is three years since this patient was cured.

Female↗
PubMedDate not supplied

[Primary hyperparathyroidism. Current aspects of its diagnosis apropos of a case with digestive and neuropsychiatric manifestations].

On the basis of a dramatic hypercalcemia revealed by digestive and neuropsychic symptoms and related to a primary hyperparathyroidism, the authors recall all the clinical circumstances which should lead to determination of plasma calcium as well as the clinical and biological particularities which, in front of a hypercalcemia, suggest a primary hyperparathyroidism. The stress the usefulness and the limits of the dosage of plasma immunoreactive parathyroid hormone as well as the difficulties to differentiale primary from paraneoplasic hyperparathyroidism. The recent pathophysiological concepts of malignant hypercalcemia reviewed.

Aged↗
PubMedDate not supplied

[Epidemiologic aspects of malaria in Gabon].

The authors report the results of 3 sample surveys carried out in Libreville, Ngounié and Haut-Ogooué Provinces to evaluate the main malarial indexes among 0 to 15 years old children in Gabon. These investigations would suggest that malaria is mesoendemic in the three areas. The systematic presumptive antimarial treatment of fever attacks is widely used in Libreville but not so frequent in rural areas.

Adolescent↗