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Biomedical subjects

A Dumitrescu

Publications and source records attributed to A Dumitrescu.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Changes of the cellular immunity tests during the evolution of Hodgkin's disease.

To detect the changes of cellular immunity which occur at the same time as the pathological process and to find out the possible biologic indicators with prognostic value, a study was carried out on 140 patients with Hodgkin's disease (HD) in different clinical periods: onset, under therapy (cytostatics and/or irradiations), remission, after splenectomy and under immunotherapy. The study of cellular immunity included the determination of lymphocytes subpopulations by the rosette tests and their functional estimation by tests of blastic transformation to mitogens and antigens. Though the values obtained presented a wide dispersion, the rosette tests showed variations in correlation with the clinical stage, therefore with the severity of disease. It was observed that therapy and splenectomy change the cellular immunity tests. The only test with a certain prognostic value was found to be the in vitro lymphocyte response to PPD which became positive after therapy, particularly in the group of patients who showed good response to treatment. A dynamic follow-up of the cellular immunity tests might give an indication on the mechanisms of production of the immune deficit in HD.

Hodgkin Disease↗
PubMedDate not supplied

[Ontogeny of the immune response in mice. I. Presence of IgG and alpha fetoprotein in the body fluids of mice of various ages].

Alpha protein and IgG were determined by radial immunodiffusion in Swiss mice, in the amniotic fluid, milk and serum of the mice at different ages (fetus, neonates, at the age of 5, 10, 15, 20, 25, 30, 35 and 40 days and adults). The highest alpha-protein concentrations were found in the fetal serum (0.20 mg/ml) ; after birth serum levels rapidly fell and at 20 days could no longer be detected ; it was present in the amniotic fluid and milk collected within the first 24 hours after birth. In contrast, IgG was found in small concentrations in the fetal serum (0.60 mg/ml) but increased with age after birth. This immunoglobulin was present in the amniotic fluid and mothers' milk for 15 days. The significance of the results is discussed.

Age Factors↗
PubMedDate not supplied

Introduction to the study of adult T-cell leukemia and HTLV-I sero-positivity in Romania.

The study presents 6 cases of leukemia/lymphoma (with mature T-cells) corresponding to the diagnostic criteria of adult T-cell leukemia (ATL): adult age onset of leukemia/lymphoma, organomegaly but normal mediastinum, leukemic cells with typical morphology and phenotype hypercalcemia. The evolution of disease was severe of subacute with resistance or partial response to therapy. The virologic assays were positive according to the ELISA test in four cases of which two presented, according to the Western blot assay, HTLV-I infection. The epidemic aspect of this infection is discussed as well as the possibility of contamination and the geographic spread of the places of origin of the patients. Emphasis is laid on the young age (22-26 years) of three of the patients infected, as a peculiar feature of the disease in Romania.

Adult↗
PubMedDate not supplied

The relationship between aminoaciduria and plasma hemoglobin levels.

Investigations in newborns, children and young adults have revealed an inverse proportion between aminoaciduria and plasma hemoglobin (Hb) levels. Values above normal were recorded for alanine, leucine, valine, phenylalanine and glutamic acid, correlating proportionally with their increased blood levels, and preceding or being concomitant with the decrease of plasma Hb, both during the first 20 months of life and in young adults. The return to near normal values of aminoaciduria occurred generally only after an early treatment with minerals, vitamins and trace elements (Supradyn), activators of the enzymes involved in the amino acid metabolism. After treatment, the Hb levels also became almost normal. An early re-equilibration of the amino acid metabolism can prevent the risk of developing, at the adult age, certain anemias and other diseases (rachitism, mental handicap, urinary infections, conjunctivitis, stomatitis, a.o.). The correlation factor was r = 0.964 and the differences between the data recorded in patients and in controls were statistically significant (p < 0.01).

Amino Acid Metabolism, Inborn Errors↗
PubMedDate not supplied

Phenotypic and functional changes in chronic lymphocytic leukemia.

The study was carried out in 170 patients with chronic lymphocytic leukemia (CLL) at the onset, grouped according to RAI staging system, and in 20 controls. Using the rosette tests (E4 degrees, E 29 degrees, EAC and M) different lymphocytic subpopulations were detected. Their functional competence was studied by in vitro response to mitogens (PHA, PWM) and to an antigen (PPD). As it is well known the mean values of these parameters in CLL were found significantly reduced as compared to controls. But when compared according to the five clinical stages in CLL, two main aspects were observed. (a) stage 0 of the disease differs from the other clinical stages by the significantly low mean values of the parameters characteristic of the B cell line namely EAC rosetting and the in vitro response to PPD and PWM. Stage 0 of the disease is closer to the normal values; (b) the response of the PWM-stimulated T-dependent B cells decreases gradually and significantly with the clinical course of the disease and hence with the advance of clinical stages. The functional contribution of the various lymphocytic populations in this test is discussed as well as their possible implication in the pathogenesis of the disease.

B-Lymphocytes↗