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Biomedical subjects

A Dolezal

Publications and source records attributed to A Dolezal.

At least 37 records · Page 2Linked to original sources
PubMed1980

Results of screening for phenylalanine and other amino acid disturbances among pregnant women.

Blood specimens were collected from 15000 pregnant women during the first 3 months of their pregnancy and screened for amino acid disturbances by means of paper chromatography. A high incidence of disturbances in the phenylalanine metabolism was discovered: three cases of mild hyperphenylalaninaemia without phenylpyruvicaciduria (incidence 1:5000); two cases of mild hyperphenylalaninaemia with phenylpyruvicaciduria (incidence 1:7550); four cases of mild phenylketonuria (incidence 1:3750). Disturbances in the metabolism of other amino acids were found to be rare. Metabolic and genealogical findings in some detected families are briefly described.

Adult↗
PubMed1978

Electrical potential difference across the mid-term human placenta.

Electrical potential difference across the mid-term human placenta was recorded during hysterotomy. The average value registered was 2.7 mV (S.E. of mean=0.4 mV, n=7), fetus negative. From this value and the concentrations of Na, K, Ca, Cl and inorganic phosphate in maternal and fetal plasma the possible mechanisms of net transport from mother to fetus are inferred. It is concluded that of the above ions only the transport of Na is compatible with simple diffusion.

Action Potentials↗
PubMed1977

Screening of amino acid enzymopathies in pregnancy and possibilities of their prenatal diagnosis.

The report discusses the first results obtained by chromatographic screening of the blood amino acids in pregnant women at the outset of pregnancy. Typical cases of maternal phenylketonuria and maternal hyperphenylalaninaemia found among 2,000 women examined are described in detail, giving a concise metabolic, clinical and genetic picture. The biochemical possibilities of diagnosing congenital disorders of amino acid metabolism before birth are also discussed.

Amino Acid Metabolism, Inborn Errors↗