Biomedical subjects
A Dodek
Publications and source records attributed to A Dodek.
Need donated hearts be entirely free from disease?
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Adverse biochemical and clinical consequences of furosemide administration.
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Serum digoxin test in perspective.
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Systolic time intervals in chronic hypertension: Alterations and response to treatment.
Systolic time interval studies were performed to evaluate left ventricular performance in 28 patients with untreated systemic hypertension but without clinical heart failure. The pre-ejection period (PEP) was significantly prolonged (p smaller than 0.001) and left ventricular ejectime time (LVET) was shortened (p smaller than 0.02) when compared to rate-corrected predicted values. The PEP/LVET ratio was abnormally high in 18 of the patients and the average ratio was 0.45 ( smaller than 0.001). Eleven patients with abnormal time intervals were restudied during treatment with antilypertensive drugs. The PEP/LVET raio decreased in ten and became normal in nine. The average ratio decreased from 0.49 to 0.41 (p smaller than 0.001), due to both shortening of PEP (p smaller than 0.02) and lengthening of LVET (p smaller than 0.001). These findings indicate that alterations in left ventricular function may occur commonly in chronic hypertension in the absence of clinical heart failure, and can be reversed with appropriate therapy. This technique may be useful in evaluating hypertensive patients and in determining the efficacy of treatment.
Percutaneous valvuloplasty: an idea whose time has come.
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Percutaneous balloon valvuloplasty for aortic stenosis: improved quality of life for elderly patients.
From September 1986 to September 1987 percutaneous balloon valvuloplasty was performed in 20 patients with critical aortic stenosis. The mean age was 74, range 54 to 90 years. Two patients were NYHA class II, 10 patients were functional class III and eight were class IV. After percutaneous balloon valvuloplasty, using 15, 18 or 20 mm diameter balloon catheters via a 14F vascular sheath from the femoral artery, one patient was class I, 11 class II and seven were class III. One patient, who had only minimal reduction of aortic valve gradient from 120 to 100 mmHg, remained in class IV. The systolic gradient was reduced by 50% from 70 +/- 26 (+/- SD) to 35 +/- 22 mmHg (P less than 0.001) after valvuloplasty and the aortic valve area increased by 43% from 0.51 +/- 0.12 to 0.73 +/- 0.25 cm2 (P less than 0.001). There were no procedural or 30 day deaths nor any embolic events. Percutaneous balloon valvuloplasty is a relatively safe and effective treatment for the older adult with symptomatic aortic stenosis.
Procainamide-induced lupus erythematosus: report of a case with a large pericardial effusion and fluid analysis.
A patient with procainamide lupus erythematosus had a large pericardial effusion. As in other reported cases histology revealed a fibrinous mononuclear pericarditis and the pericardial fluid was a serosanguinous inflammatory exudate with a high LDH level and normal glucose concentration. The ANF and LE cell preparation were positive in the fluid but the C3 complement was normal. The frequency of pericarditis is similar in systemic and drug-induced lupus erythematosus yet low complement levels need not occur. Complement activation may therefore be unnecessary for the development of either type of lupus pericarditis.