Lymphocyte membrane modifications induced by acetylasalicylic acid and dipyridamole.
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Aspirin↗
Biomedical subjects
A Dirksen
Publications and source records attributed to A Dirksen.
[Problem-oriented medical record].
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Denmark↗
[Assessment of independence in daily life in pediatric oncology by FMH-questionnaire].
Therapy-related late effects are important for therapeutic decisions in pediatric oncology. We quantified the degree of impairment of independence in daily life in children with cancer. The German questionnaire "Fertigkeitenskala Münster/Heidelberg (FMH)" is a standardized tool for measurement of motoric and verbal functioning. A point-score leads to an age-related percentile ranking similar to typical percentiles in pediatrics. We used the FMH in 215 cancer patients (mean age 10.3 years, range 0.5-23.5 years, 56.3% male). Diagnoses were leukaemia (n = 91), bone tumors (n = 33), nephro- and neuroblastoma (n = 21), brain tumors (n = 18), lymphoma (n = 23), rhabdomyosarcoma (n = 11) and others (n = 18). The average time to answer the questionnaire was 4.5 min. Patients with brain and bone tumors showed significant lower percentile scores compared to patients with other diagnoses (p < 0.05). The FMH-scores increased with time since diagnosis (n = 215). This trend was confirmed in a longitudinal study over one year (n = 29). Quantitative assessment of independence and functioning in patients with cancer--especially in multicenter-studies--is possible. Because of therapy-related late effects this seems to be of special importance in brain and bone tumor patients.
Activities of Daily Living↗
[Munster Heidelberg Abilities Scale--a measuring instrument for global comparison of illness sequelae].
An instrument to measure quality of life in multicentric pediatric studies in German language was missing yet. The FMH measures the capability for daily life actions with 56 items like "can walk without aids" or "earns money". It was normalized with 971 persons (45.5% female) aging between 0 and 102 years resulting in age-dependent percentiles. The retest-reliability-coefficient is 0.99. The validity was tested in 10 brain tumor patients: there was a good agreement with the IQ (r = 0.7) and with a semiquantitative assessment by a physician (p < 0.001).
Activities of Daily Living↗
Allergic contact sensitization in an adult Danish population: two cross-sectional surveys eight years apart (the Copenhagen Allergy Study).
In 1990 and 1998 15-41-year-old people were patch-tested in 2 cross-sectional studies of random samples of the population in the western part of Copenhagen County, Denmark. In 1990, 290 subjects and in 1998, 469 subjects were patch-tested. The participation rates were 69% and 51%, respectively. Contact sensitivity to one or more haptens was found in 15.9% and 18.6% in 1990 and 1998, respectively. Nickel sensitivity is still the most common contact sensitivity. The risk of contact sensitivity to the cosmetic-related haptens included in the series (formaldehyde was not included) increased significantly from 2.4% in 1990 to 5.8% in 1998 (odds ratio 2.44, 95% confidence interval 1.04-5.73). The prevalence of contact sensitivity to cosmetic-related allergens has been doubled between 1990 and 1998.
Adolescent↗
Comparison between specific IgE measured by RAST, two chemiluminescent assays and skin prick test.
Two hundred adult patients referred to a regional outpatient allergy clinic were skin prick tested and their specific IgE against ten inhalant allergens was measured by three different assays: the classical radioallergosorbent assay, Phadebas RAST (P-RAST), (Pharmacia AB, Uppsala, Sweden), the multi-allergosorbent chemiluminescent assay CLA (MAST), (Dome/Hollister-Stier, Miles Ltd., UK), and the immunocheminometric assay, MAGIC LITE SQ Specific IgE (ML), (ALK Laboratorierne, Hørsholm, Denmark). Skin prick test (SPT) was performed with extracts from the same companies. Marked differences between the assays were seen especially in the low range. Specific IgE was detected in 17% of the samples by P-RAST, in 66% by CLA, and in 17% by ML. Frequency distribution of P-RAST and ML measurements showed a peak at zero and a gradual decline towards larger values, whereas distribution for CLA was U-shaped with a peak at zero and another peak close to maximum reactions. Kendall's rank correlation coefficient being 0.80 for P-RAST vs. CLA. Correlation coefficient between measurements of specific IgE and SPT was high for CLA (0.65). Even in the low-level subgroup where IgE was detected by CLA only, a high correlation (0.60) between CLA and SPT was observed. In conclusion marked differences were observed between the three assays for specific IgE measurement. The CLA system seems to be more sensitive than the conventional P-RAST and ML, but further studies should reveal whether this extra sensitivity is clinically useful.
Adolescent↗
Skin prick testing with standardized extracts from 3 different manufacturers. A comparative randomized study.
The aim of this study was to compare skin reactivity to routine allergen prick test with panels of allergens, supplied by three different manufacturers. The allergens comprised ten aero-allergens commonly used for skin prick test in Northern Europe, and included pollen, dander, house dust mites, and moulds. Two hundred consecutive patients were tested. The methods for standardization of allergen extracts, declaration of allergenic potency, and recommended lancets differed. The equipment were Soluprick SQ (Allergologisk Laboratorium A/S, Denmark) (ALK), Alphatest (Dome/Hollister-Stier, U.K.) (DHS), and Phazet (Pharmacia, Sweden) (PHA). The coefficient of variation for the allergen coated PHA (same lancet was applied twice) was 0.31, and for ALK and DHS allergen extracts 0.13 and 0.18, respectively. The frequencies of patients with positive reactions to the various allergens were generally similar, although DHS appeared to elicit less positive reactions to Timothy, dog, and Dermatophagoides pteronnyssinus. For the individual physician, it may be important to know the allergenic activity of the different allergens in his routine panel compared to the activity in other similar panels.
Adolescent↗
Intraindividual variation and effect of learning in lung function examinations. A population study.
The aims of this study were to analyse the influence of co-operation and instruction on inter-and intraindividual variations of normal lung function and to provide reference values for intraindividual variation. A sample of 125 non-smokers (age 30-70 yr) representative of the population of Copenhagen were studied with spirometry, complete and partial flow-volume curves, nitrogen washout volume, volume of trapped gas and transfer factor. The examination was repeated 0.5-6 months later for 112 of the individuals. Much of the variance observed at the first examination, i.e. interindividual variation, could be accounted for by the sex, age, height and weight of the individuals, whereas differences in individual motivation, social status, the ability of the technicians to instruct during the examination and interactions induced by the subject and the technician being of the same or of opposite sex were negligible. The intraindividual difference between the second and the first examinations were very small. Factors such as the subjects' sex, age, height, weight, social status, motivation, whether the examination was conducted by the same or a different technician at the two examinations, and whether the interval of time between the two examinations was short or long, were insignificant. It is concluded that while much of the interindividual variance of a lung function test is influenced by a variety of confounding factors, the intraindividual variation is not. Reference values for intraindividual variation are given.
Adult↗
Calculation of reference values for lung function tests.
The powerful computers that are now available enable calculation of reference values by endless permutations of regression models that are not always biologically meaningful. The aim of this study was to test the ability of simple regression models to describe data that has been collected for calculation of reference values. Healthy non-smoking females (n = 74) and males (n = 51) were studied with 22 commonly used lung function tests. If the data were logarithmically transformed, there was a satisfactory reduction of residual variation and the assumption of normality was fulfilled. Furthermore, the difference between males and females could be described by a binary sex-variable that is independent of interactions with other variables such as age, height and weight. Logarithmic transformation of lung function measurements followed by linear regression is recommended as a simple standard method for calculation of reference values.
Adult↗