Letterer-Siwe disease. Report of a case emphasizing effective corticosteroid therapy.
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Histiocytosis, Langerhans-Cell↗
Biomedical subjects
A Diamond
Publications and source records attributed to A Diamond.
The effects of cognitive-behavioural therapy in chronic pain.
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Chronic Disease↗
Identification and molecular cloning of the human Blym transforming gene activated in Burkitt's lymphomas.
DNAs of six Burkitt's lymphoma cell lines contained an activated transforming gene detected by transfection of NIH 3T3 cells. This gene was cloned from a recombinant library of Burkitt's lymphoma DNA and identified as a human homologue of chicken Blym-1, the transforming gene detected by transfection of chicken B-cell lymphoma DNA.
Base Sequence↗
Close interrelation of motor development and cognitive development and of the cerebellum and prefrontal cortex.
Motor development and cognitive development may be fundamentally interrelated. Contrary to popular notions that motor development begins and ends early, whereas cognitive development begins and ends later, both motor and cognitive development display equally protracted developmental timetables. When cognitive development is perturbed, as in a neurodevelopmental disorder, motor development is often adversely affected. While it has long been known that the striatum functions as part of a circuit with dorsolateral prefrontal cortex, it is suggested here that the same is true for the cerebellum and that the cerebellum may be important for cognitive as well as motor functions. Like prefrontal cortex, the cerebellum reaches maturity late. Many cognitive tasks that require prefrontal cortex also require the cerebellum. To make these points, evidence is summarized of the close co-activation of the neocerebellum and dorsolateral prefrontal cortex in functional neuroimaging, of similarities in the cognitive sequelae of damage to dorsolateral prefrontal cortex and the neocerebellum, of motor deficits in "cognitive" developmental disorders, and of abnormalities in the cerebellum and in prefrontal cortex in the same developmental disorders.
Cerebellum↗
Inability of five-month-old infants to retrieve a contiguous object: a failure of conceptual understanding or of control of action?
Infants of 5 to 6 months of age can retrieve a free-standing object, but fail to retrieve the same object from atop a slightly larger object. The accepted explanation has been that the infants do not understand that an object continues to exist independently when placed upon another. Predictions based on that explanation were tested against the hypothesis that infants' problem consists of lack of precision in visually guided reaching and lack of ability to inhibit reflexive reactions to touch. Twelve infants each at 5 and 7 months of age were tested on 16 trials. More 5-month-olds succeeded, in less time, and with fewer touches to an edge of the base, on trials more forgiving of an imprecise reach than on less forgiving trials. Success in retrieving objects close in size and fully contiguous with their bases was seen even at 5 months when the demands on skill in reaching were reduced. It is proposed that when 5-month-old infants fail to retrieve one object placed upon another, it is not because of a lack of conceptual understanding, but because they lack the skill to reach to the top object without accidentally touching an edge of the base en route.
Concept Formation↗