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Biomedical subjects

A Deutsch

Publications and source records attributed to A Deutsch.

At least 19 recordsLinked to original sources
PubMed1998

Unaltered cosmic spherules in a 1.4-Gyr-old sandstone from Finland.

Micrometeorites-submillimetre-sized particles derived from asteroids and comets-occur in significant quantities in deep sea sediments, and the ice sheets of Greenland and Antarctica. The most abundant micrometeorites are cosmic spherules, which contain nickel-rich spinels that were crystallized and oxidized during atmospheric entry, therefore recording the oxygen content in the uppermost atmosphere. But the use of micrometeorites for detecting past changes in the flux of incoming extraterrestrial matter, and as probes of the evolution of the atmosphere, has been hampered by the fact that most objects with depositional ages higher than 0.5 Myr show severe chemical alteration. Here we report the discovery of unaltered cosmic spherules in a 1.4-Gyr-old sandstone (red bed) from Finland. From this we infer that red beds, a common lithology in the Earth's history, may contain substantial unbiased populations of fossil micrometeorites. The study of such populations would allow systematic research on variations in the micrometeorite flux from the early Proterozoic era to recent times (a time span of about 2.5 Gyr), and could help to better constrain the time when the atmospheric oxygen content was raised to its present level.

Earth, Planet↗
PubMed1998

Rasch analysis of the Functional Independence Measure (FIM) Mastery Test.

OBJECTIVE: To evaluate the range, distribution, and unidimensionality of the items included in Version Five of the Functional Independence Measure (FIM) Mastery Test, a 54-item written examination used to determine FIM rating proficiency by professionals who administer the instrument. STUDY DESIGN: Rasch analysis of the test results of 6,645 clinicians who took the FIM Mastery Test in 1996. RESULTS: Overall, clinicians performed well on the test. When the mean item difficulty was centered at 50, and the test scores were calibrated to range from 0 to 100 logits, the mean person ability level was 77 logits. Fit statistics indicated that the test was unidimensional, measuring a common theme. While the item separation index value was 17, 22 items were not efficient in determining the clinicians' ability levels. Analysis of the logit values by the correct response showed that descriptions of Total Assistance (Level 1) and Complete Independence (Level 7) were easiest for clinicians to score correctly. CONCLUSION: The examination measures the common theme of FIM knowledge in a consistent manner. Further, the results suggest that the FIM Mastery Test may be shortened, perhaps by eliminating one of the three case studies, and improved by adding more challenging questions. In addition, FIM training should focus on distinguishing among levels 2 through 6, since clinicians had more difficulty identifying these levels.

Activities of Daily Living↗
PubMed1998

Activity of cellulolytic enzymes in the contents of reticulorumen and caecocolon of roe deer (Capreolus capreolus).

Selective ruminants, which prefer easily digestible plants, cannot digest fibrous forage as well as grass eaters. Low enzyme activity or short retention time of ingesta particles in fermentation chambers appeared to be responsible for reduced cellulose breakdown. Seasonal activity of cellulolytic enzymes, cellulose concentration and protozoa population in reticulorumen (RR) and caecocolon (CC) of roe deer as a typical concentrate selector were investigated. Cellulase activities were lowest in winter when cellulose concentration in RR contents were highest. Highest enzyme activities and lowest cellulose concentration were measured in early spring. Cellulolytic activities were significantly correlated with the number of protozoa in RR. Only one entodinomorphic genus was identified in the RR. The enzyme activities in CC were far lower compared with those in RR. Low cellulose digestion in the RR cannot be compensated for by cellulose breakdown in the CC. The reduced cellulose digestion of roe deer may be attributed to the short retention time of food particles in spring and summer, whereas decreased colonisation of microorganisms in the rumen may be the main reason for low cellulose breakdown in winter.

Animals↗
PubMed1998

Verbs and nouns are organized and accessed differently in the mental lexicon: evidence from Hebrew.

A masked priming paradigm was used to examine the role of the root and verbal-pattern morphemes in lexical access within the verbal system of Hebrew. Previous research within the nominal system had showed facilitatory effects from masked primes that shared the same root as the target word, but not when the primes shared the word pattern (R. Frost, K. I. Forster, & A. Deutsch, 1997). In contrast to these findings, facilitatory effects were obtained for both roots and word patterns in the verbal system. In addition, verbal pattern facilitation was obtained even when the primes were pseudoverbs consisting of illegal combinations of roots and verbal patterns. Significant priming was also found when the primes and the targets contained the same root. The results are discussed with reference to the factors that may determine the lexical status of morphological units in lexical organization. A model of morphological processing of Hebrew words is proposed.

Humans↗
PubMed1997

What can we learn from the morphology of Hebrew? A masked-priming investigation of morphological representation.

All Hebrew words are composed of 2 interwoven morphemes: a triconsonantal root and a phonological word pattern. the lexical representations of these morphemic units were examined using masked priming. When primes and targets shared an identical word pattern, neither lexical decision nor naming of targets was facilitated. In contrast root primes facilitated both lexical decisions and naming of target words that were derived from these roots. This priming effect proved to be independent of meaning similarity because no priming effects were found when primes and targets were semantically but not morphologically related. These results suggest that Hebrew roots are lexical units whereas word patterns are not. A working model of lexical organization in Hebrew is offered on the basis of these results.

Decision Making↗
PubMed1997

Comparison of the immunobead binding test (IBT) and immunospheres (IS) assay for detecting serum antisperm antibodies.

PROBLEM: The IBT is considered the gold standard of sperm antibody assays. This test uses polyacrylamide beads labeled with antiglobulins (anti-IgG, anti-IgA, and anti-IgM), which bind to the corresponding antibody on the sperm surface. The IS uses color-coded latex beads of uniform 3.0 microns size coated with the antiglobulins which can be viewed with brightfield light microscopy. The purpose of the present study was to compare the IBT and IS in an indirect test using human serum. METHOD: Serum specimens (n = 42) were tested for the presence of antibody isotypes IgG, IgA, and IgM to sperm using the standard protocol for IBT and IS. Donor sperm was washed in BWW with 5% BSA and diluted to a final concentration of 50 x 10(6) motile sperm/ ml. The sperm were incubated with a 1:10 dilution of test serum for 30 min to 1 h at 37 degrees C and then washed by three cycles of centrifugation. The sperm and beads (IBT, IS) were mixed on a glass slide, covered with a coverslip, and observed within 5 min. At least 100 motile sperm were counted and scored for bead binding. A specimen was considered positive if 20% or more of the sperm were coated with one or more beads. The data were analyzed using calculation of the non-parametric kappa statistic with correction for chance expected agreement, and by calculating the proportion of specific agreement between the two methods. RESULTS: The results are summarized in the following table: [table see text]; The IS was able to detect 94% of IgG antibodies, 91% of IgA antibodies, and 100% of IgM antibodies. One serum specimen was IgG negative by IS (14% binding), but positive by IBT (20%). A second serum specimen was IgA negative by IS (16%) yet positive by IBT (29%). There were no false positives with the IS assay. Of the IgM positives (five of six) occurred alone and not with IgG or IgA, suggesting the necessity for testing all specimens also for IgM. CONCLUSION: Antisperm antibody test results obtained by the IS assay are in agreement with the results obtained with the IBT test. The Immunospheres are monodispersed, color coded, and can be visualized with brightfield microscopy.

Acrylic Resins↗
PubMed1996

Attention factors mediating syntactic deficiency in reading-disabled children.

Syntactic context effects on the identification of spoken words, and the involvement of attention in mediating these effects, were examined in seventh-grade children with reading disabilities and children who were good readers. The subjects were asked to identify target words that were masked by white noise. All targets were final words embedded in unveiled sentences. Relative to a syntactically neutral context, the identification of targets whose morpho-syntactic structure was congruent with the context was facilitated and the identification of syntactically incongruent targets was inhibited. Reading-disabled children were less inhibited by syntactic incongruence than good readers. Presenting congruent and incongruent sentences in separate blocks reduced the amount of inhibition in good readers while having no effect on the reading-disabled. The percentage of correct identification of incongruent targets in the mixed presentation condition was larger for reading-disabled than for good readers, whereas in the blocked presentation condition the percentage of correct identification was equal across groups. The amount of facilitation was not affected by blocking the congruent and incongruent conditions, and was equal across reading groups. It is concluded that, in both reading groups, the syntactic structure of the context triggers a process of anticipation for particular syntactic categories which is based on a basic assumption that linguistic messages are syntactically coherent. Reading-disabled children are, however, less aware of this process and therefore less affected when the syntactic expectations are not fulfilled.

Adolescent↗
PubMed1996

An uncommon presentation of Salmonella.

Salmonella infection can cause appendicitis by direct invasion of the appendix, or can mimic appendicitis by causing mild inflammation of the appendix, ileum, or lymph nodes. Clinical presentation and radiologic and laboratory evaluation may not distinguish the extent of underlying pathology. This case of a child with an atypical presentation of Salmonella who underwent diagnostic laparotomy illustrates the overlap of enteric infections and acute appendicitis. A literature review confirms the variety of clinical scenarios of patients with suspected appendicitis and Salmonella-positive cultures. We conclude that enteric infection should be considered in children with atypical presentations of appendicitis, and that the knowledge that Salmonella can progress to appendicitis should guide management if signs and symptoms of appendicitis develop.

Adolescent↗
PubMed1995

Thoracic spinal nerve and root conduction: a magnetic stimulation study.

We describe a technique of magnetic coil (MC) stimulation of the thoracic spinal nerves and roots in 12 normal subjects and a patient with diabetes mellitus. We kept the MC flat against the vertebral column in the midline over T-7, T-8, and T-9 spinous processes and obtained compound muscle action potentials from the upper rectus abdominis, external oblique, and intercostal muscles. We obtained mean latencies to these muscles after stimulation in the posterior axillary line. We noted that the onset latencies remained fixed despite increasing the intensity of stimulation from 30% to 100% and on moving the coil up to 3 cm lateral to the spinous processes suggesting that the stimulation of the fastest conducting fibers was occurring at a fixed site, most likely at the intervertebral foramina. Prolonged latencies in the diabetic patient confirmed the diagnosis of radiculoneuropathy.

Adult↗
PubMed1995

Percutaneous magnetic coil stimulation of the phrenic nerve roots and trunk.

We describe a technique of percutaneous magnetic coil (MC) stimulation of the phrenic nerve trunk on one side of the neck and phrenic roots over the upper cervical vertebral column in 10 normal subjects and 2 patients. We were able to obtain compound muscle action potentials (CMAPs) from the diaphragm at two sites (xiphoid process and 7th intercostal space) after stimulation of the phrenic nerve trunk and roots. We noted that the onset latencies after phrenic root stimulation remained fixed despite increasing the stimulus intensity from 50% to 100% and on moving the MC vertically or laterally, suggesting that stimulation of the fastest conducting fibers was occurring at a fixed site, most likely at the intervertebral foramina. Absent responses unilaterally in one and prolonged latencies to diaphragmatic CMAPs in another patient confirmed phrenic neuropathy in these patients.

Action Potentials↗
PubMed1995

Personality traits in schizophrenia.

In recent years there has been a renewed interest in the integration of descriptive and interpersonal approaches to mental illness. Much of the impetus for this stems from the introduction in 1980 of the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) (American Psychiatric Association 1980), with subsequent research and clinical reports documenting important interactions between Axis I syndromes and Axis II personality trait factors. While many research efforts have described comorbidity in affective and anxiety disorders, less attention has been directed toward clarifying the relationships between stable and enduring character traits and Axis I symptoms in schizophrenia. In this paper we propose that schizophrenic patients display both adaptive and pathological personality traits throughout the illness, and that clinical and research efforts to address the interactions between syndromic and personality factors ("trait-state" interactions) will further our understanding of patterns of symptom presentation and treatment response in these patients.

Adult↗
PubMed1995

Elevated superoxide generation in mononuclear phagocytes by treatment with 1 alpha hydroxyvitamin D3: changes in kinetics and in oxidase cytosolic factor p47.

The effect of 1 alpha-hydroxyvitamin D3 (1 alpha OHD3) treatment on the superoxide production of phagocytic cells in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) was studied. A 3-day treatment of CAPD patients with 3 micrograms per day of 1 alpha OHD3 (high-dose treatment) significantly increased NADPH oxidase and killing activities in peritoneal macrophages and peripheral blood monocytes (P < 0.001) as compared with low-dose (0.25 microgram/day of 1 alpha OHD3) treatment or nontreatment. The high oxidase activity observed in macrophages and monocytes after the treatment with 1 alpha OHD3, correlated significantly to the increase in the amount of the cytosolic factor p47 of the NADPH oxidase as detected by western blotting analysis. Superoxide production by the peripheral blood neutrophils of these patients only slightly increased with 1 alpha OHD3 treatment, and the amount of p47 was not affected by 1 alpha OHD3 administration. In order to evaluate the significance of the oxidase cytosolic factor in dictating oxidase activity, a reconstitution of NADPH oxidase was conducted by mixing macrophage cytosols and membranes in a cell-free system. The addition of macrophage cytosol from patients on high-dose treatment to macrophage membranes from patients in all of the categories of treatment resulted in significantly higher (P < 0.001) superoxide production as opposed to the macrophage cytosol from nontreated patients. These results suggest that 1,25(OH)2D3 causes an increase in NADPH oxidase activity in the peritoneal macrophages and monocytes of CAPD patients by inducing synthesis and elevating the amount of the cytosolic factor p47.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcitriol↗
PubMed1994

Atrial natriuretic peptide and its potential role in pharmacotherapy.

Atrial natriuretic peptide (ANP) is a 28 amino-acid polypeptide secreted into the blood by atrial myocytes after atrial pressure and distension. Although its role in humans is not clear, it can produce a variety of physiologic effects including vasodilatation, natriuresis, and suppression of the renin-angiotensin-aldosterone axis. These actions are potentially useful in a variety of pathologic states such as hypertension and congestive heart failure, and diverse methods to augment the effects of ANP in these states have been devised. The results are exciting and, despite some problems, may lead to the pharmacologic use of enhancement of ANP actions in several clinical disorders.

Atrial Natriuretic Factor↗
PubMed1994

Symptomatic intraarticular ganglia of the cruciate ligaments of the knee.

This case report draws attention to the clinical presentation, differential diagnosis, and recommended diagnostic modality and treatment of symptomatic ganglia of the anterior and posterior cruciate ligaments. One patient presented with a recurrent inability to fully extend the left knee. Another patient presented with pain and soreness over the lateral aspect of the knee, including the lateral joint line. The diagnosis of ganglia of the cruciate ligaments was made after clinical, radiographic, and magnetic resonance examination. Both patients were treated successfully with resection of their ganglia using arthroscopic techniques.

Adult↗
PubMed1994

The superolateral portal for arthroscopy of the shoulder.

With the advent of arthroscopic procedures for the treatment of a variety of clinical conditions affecting the shoulder has come the need for better techniques for visualization of structural pathology, and better techniques for visualization of intracapsular structures during operative procedures. We present a new portal for shoulder arthroscopy that is safe to insert, providing a panoramic view of the glenohumeral joint (especially anteriorly), and allowing unobstructed observation of large instruments passed through more traditional anterior portals nearby. The superolateral portal is particularly suited for use in anterior stabilization procedures of the shoulder, where it can be used for direct visualization of the anterior glenoid neck, thus permitting the surgeon to perform such tasks as debridement or mobilization of tissues, and placement of tacks or sutures.

Arthroscopes↗
PubMed1994

Attention mechanisms mediate the syntactic priming effect in auditory word identification.

The syntactic priming effect and the involvement of attention in that process were investigated by testing identification of white noise-masked Hebrew words. Targets were either syntactically congruent or syntactically incongruent with the structure of the sentence. Relative to a neutral condition, similar facilitation and inhibition was found for congruent and incongruent targets, respectively. When syntactic congruency was blocked, the inhibition was attenuated, whereas the facilitation remained the same. A 350-ms silent interstimulus interval between context and target increased inhibition without affecting facilitation. We suggest that both the facilitation and the inhibition effects of syntactic priming are based on a veiled controlled process of generating expectations. The inhibition results from a controlled process of reevaluation that requires additional attention resources.

Acoustic Stimulation↗