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Biomedical subjects

A Desaulty

Publications and source records attributed to A Desaulty.

At least 55 records · Page 3Linked to original sources
PubMed1982

A randomized EORTC trial comparing intra-arterial infusion with methotrexate vs bleomycin as initial therapy in carcinoma of the oral cavity.

Either intra-arterial infusions of MTX (500 mg over 10 days) or intra-arterial infusions of BLM (95 mg over 13 days) were administered as initial treatment to 85 patients with untreated squamous cell carcinomas of the oral cavity. Tumour regression was assessed 10-15 days after the end of chemotherapy. A sequential analysis was used, and BLM demonstrated a significantly greater local efficacy after the 32nd matched pair was assessed. The same results were observed when tumour response rates were compared, ignoring the matching, on the 85 patients, (P less than 0.001). The response rate for patients with neck nodes was low (10/38). Catheter management problems, toxic effects and lethal reactions were 2.5 times more frequent in the MTX group.

Bleomycin↗
PubMed1979

[Nasopharyngeal fibroma (author's transl)].

The authors report 17 cases nasopharyngeal fibroma treated between 1966 and 1978. Half of the cases developed before the age of 16, the other half occurring between 16 and 28 years. Arteriography was performed in only 8 cases and embolisation in 4 cases with 2 vascular accidents. Surgery was performed in 16 cases (15 Rouge Denker, 1 paralatero nasal). Invasion of the pterygomaxillary fossa was invariably found at operation. Amongst the patients treated by surgery, there was only one local recurrence and reoperation was successful. Finally, one patient with a very large fibroma with invasion of the temporal fossa was successfully treated by radiotherapy at a dose of 4 000 R.

Adolescent↗
PubMed1976

[Phonation following reconstructive laryngectomy].

The authors describe the results obtained, from the point of view of vocal function in 43 cases of patients who underwent various types of reconstructive laryngectomy: trachio-hyoido-epiglotto-pexy (Arslan and Serafini), crico-hyoido-pexy (Labayle), crico-hyoido-epiglotto-pexy (J.J.Piquet). These operations have as their main aim the preservation of vocal function, for social particularly as it is, increasingly, young people who are affected. The survey was carried out by means of measurement of volume, sonagraph recordings, recordings of movements of the neoglottis by accelerometer and integrating amplification. This method makes it possible to classify voices more objectively. The survey shows the importance of surgical methods and the prime importance of post-operative orthophonic re-education; results have proved very satisfactory three to six months after the operation.

Deglutition↗