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Biomedical subjects

A Delitala

Publications and source records attributed to A Delitala.

27 records · Page 2Linked to original sources

Recent experience in the management of meningeal hemangiopericytomas.

Although the histogenesis of meningeal hemangiopericytomas (HMP) remains controversial, both biological and clinical evidence seems to identify these neoplasms as a separate entity with respect to meningiomas. In order to assess the current prognosis of HMP we reviewed our personal experience limited to the last decade (1986-1995): during this period 7 patients (4M, 3F) were treated by surgery alone or surgery combined with postoperative radiotherapy. In spite of meticulous attempts at radical resection, the tumors recurred in all but two cases with a mean interval of 85 months, and a total of 18 operations were performed (2.57/patient; range 1-4). Massive intratumoral hemorrhage determined acute deterioration and required emergency surgery in two cases while in one patient diffuse visceral metastases were discovered at autopsy. Five patients are still alive at follow-up but only 2 of them are in good neurological conditions and without evidence of disease. These results are similar to those reported in other series. In view of our results we conclude that intracranial hemangiopericytomas still have a dismal prognosis. Advances in neuroimaging, neuroanesthesia, microneurosurgery and adjuvant therapy do not seem to have significantly affected the recurrence rate, quality of life and mortality.

Adult↗

[Encephaloceles. with special reference to the diagnostic difficulties].

We have studied 15 occipital, 3 frontal and one parietal cases of encephaloceles from the point of view of the etiopathogenetic, clinic and especially diagnostic problem. The diagnosis of M.E. is based on: 1) the x-ray demonstration of the bone-gap by particular projections and by tomography; 2) in the frontal M.E. the presence of face deformity, with hipertelorism and widening of nose bridge and the finding of ectopic tissue in the nose or in the oral cavity in presence of palatoschisis. Cerebral angiography and pneumoencephalography, made by tomography, are useful to show the herniated brain, hydrocephalus and other associated anomalies. Finally we think computerized tomography (C.T.) is very important for the diagnosis, since it shows the herniation, the bone-gap and the kind of herniated tissue.

Abnormalities, Multiple↗

Microsurgical DREZ-lesion in the treatment of deafferentation pain.

The lesion of the dorsal root entry zone (DREZL) of the spinal cord, recently introduced by Nashold and performed with radiofrequency or with laser, may be carried out with a microsurgical technique. Since 1978 up 1982 we have treated a series of 12 patients suffering from Pancoast's syndrome with a C8-T2 selective posterior rhizotomy (SPR). It has been observed that every deafferentative aspect of the pain was completely relieved. Such effect on the deafferentative aspect of the pain was most probably due to a lesion on the perforating vessels feeding the posterior grey horn. The lesion of this structure was therefore ischemic and this operation had to be indicate for the treatment of such pain. A series of 8 patients, suffering from cancer pain projected to anaesthetic areas, and 2 patients with benign post-thoracotomy pain, underwent to microsurgical DREZ lesion. The relief from pain was complete and no complications concerning pyramidal or posterior pathways involvement was observed. Preliminary good results suggest that a more selective lesion is possible with the microsurgical DREZ. It should be interesting a comparison between more large series of microsurgical DREZL and the more tested radiofrequency lesion.

Adult↗