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Biomedical subjects

A Del Genio

Publications and source records attributed to A Del Genio.

At least 37 records · Page 2Linked to original sources
PubMed1986

Pharyngoesophageal transmucosal potential difference in normal subjects and in patients with peptic esophagitis.

Results of a study carried out on pharyngoesophageal transmucosal potential difference (PD) in normal subjects and in patients with peptic esophagitis are reported. Ten healthy individuals used as control group and 12 patients with peptic esophagitis were examined. In all the cases an electric junctional pharyngoesophageal zone was evidenced, characterized by increased negativity at the level of the upper esophageal sphincter between the pharyngeal and esophageal potential difference. No statistically significant differences were observed between the two groups as for the length of PD and its location, which was always shown to be included in the high pressure zone. In healthy subjects the pharyngoesophageal PD was -16.2 +/- 4.23 mV; in patients with peptic esophagitis PD was -25.4 +/- 8.51 mV. However, in the latter PD was shown to be higher than normal in 66% of cases (p less than 0.01). No correlation was evidenced between PD values and manometric alterations of the upper esophageal sphincter. On this basis, such alterations should not be related to possible mucosal injuries, as suggested by several authors, but most likely to a reflected or primary phenomenon, common to that causing the gastroesophageal reflux.

Esophagitis, Peptic↗
PubMed1985

[Behavior of the pressure of the lower esophageal sphincter after intravenous administration of domperidone in normal subjects].

Manometric studies on the action of domperidone 10 mg and 20 mg i.v. on the lower esophageal sphincter pressure (LESP) have been carried on ten healthy volunteers. Domperidone inhibits dopamine receptors and results in an increase of LESP. A dose of 10 mg produces a significant increase in LESP which is rapid and prolonged for thirty minutes; a dose of 20 mg is less efficient. The stimulatory effect of domperidone on LESP suggests an important role for endogenous dopamine as an inhibitory neuromodulator of LES pressure. The use of domperidone in therapy for reflux esophagitis is suggested.

Adult↗
PubMed1985

Radionuclide techniques in the study of delayed gastric emptying in patients with gastroesophageal reflux.

Gastric emptying was studied in 15 patients with hiatal hernia and gastroesophageal reflux by a radionuclide technique with solid meal. Thirteen healthy subjects were used as control group. The obtained results have shown that, even in the time when the radionuclide activity decreases of 50% in the region of gastric activity (T1/2) in the 15 patients was not statistically different with respect to the control group, ten patients showed delayed emptying (116.4 +/- 16.88 min) with a mean delay of 30% in the time of half-emptying with respect to the control group (p less than 0.01). This finding is important for its surgical implications since this delayed emptying should be kept in mind when planning Nissen fundoplication or other antireflux procedures: in such case surgery can be complicated with a "gas bloat syndrome".

Adult↗
PubMed1984

Acute aperistaltic megaesophagus as a complication of Nissen fundoplication: a case report.

A case of acute aperistaltic megaesophagus which arose after Nissen fundoplication for sliding hiatal hernia, is reported. The resolution of the clinical and instrumental picture with cholinergic drugs leads to the conclusion that the phenomenon observed is of vagal origin. This may be an extreme picture of the mild esophageal dilatation and transitory dysphagia that sometimes occur after Nissen fundoplication.

Esophageal Achalasia↗