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Biomedical subjects

A Deganello

Publications and source records attributed to A Deganello.

16 recordsLinked to original sources
PubMed2006

Use of the infra hyoid musculo-cutaneous flap in soft palate reconstruction.

AIMS: To review a series of 23 consecutive patients with squamous cell carcinomas arising from oropharynx who underwent infra hyoid musculo-cutaneous flap reconstruction including soft palate in alternative to free radial forearm flap or maxillofacial prosthesis. Post operative radiotherapy was performed for all patients. RESULTS: Every reconstruction healed quickly without major wound complications. The functional results evaluated by speech and swallowing capacities, were good for 17 patients, fair for 4 patients and bad for 2. CONCLUSIONS: The infra hyoid musculo-cutaneous flap is a versatile, reliable and convenient flap suitable for repairing small and medium sized defects; it can be used in combination with other flaps, and in selected cases obviates the need for a microvascular free radial forearm flap or maxillofacial prosthesis.

Adult↗
PubMed2005

Infrahyoid myocutaneous flap reconstruction after wide local excision of a Merkel cell carcinoma.

The case is presented of an 8 1-year-old female coming to our observation after two non radical local excisions of a Merkel cell carcinoma of the sub-mental skin region. After a wide local excision, with en bloc elective bilateral neck dissection, simultaneous reconstruction with an infra-hyoid myocutaneous flap was performed. A brief overview concerning this rare tumour is presented and the surgical technique of the reconstructive procedure is described in detail. The infra-hyoid myocutaneous flap represents a reliable flap, easy and quick to prepare, limiting the time of surgery. The donor site can be primary closed avoiding skin grafting or scars beyond the head and neck area with no significant cosmetic or functional sequelae in the donor area. In this elderly patient, reconstruction with an infra-hyoid myocutaneous flap appears to have been the best option for closing the surgical defect.

Aged↗
PubMed1993

Reflux esophagitis in children: a scanning and transmission electron microscopy study.

In children, excess of gastroesophageal reflux causes lesions of the esophageal mucosa that we have studied by scanning and transmission electron microscopy (SEM and TEM respectively) in 27 grasp biopsies prelevated during endoscopic procedures. Ultrastructural lesions can be graded on the basis of their severity. In grade I, epithelial cells are well preserved in the deepest layers whereas the superficial cells display ultrastructural alterations such as irregular microridges or reduced intercellular junctions. In grade II, the surface is composed of extruding cells and in the intermediate layer, large intercellular spaces containing lympho-monocytic cells are visible. In grade III, the mucosal surface is characterized by crater-like erosions, degenerating cells are visible in all the layers; in two patients columnar epithelium-lined areas (Barrett's esophagus) have been identified. Our results suggest that in patients with reflux esophagitis, ultrastructural examination of grasp biopsies prelevated by pediatric endoscopes allows a grading of the anatomical lesions providing data that can not be obtained by conventional histology.

Adolescent↗
PubMed1992

Surfactant-like material in the antral gastric mucosa of children.

It has been proposed that the hydrophobicity of the gastric mucosa is due to surfactant-like material (SLM), mainly composed of phospholipid, adsorbed to the mucosal surface. Biochemical and physiological studies have been performed in different mammals but morphological data on children are lacking. In the present work, the presence of SLM on the antral gastric mucosa of children has been studied by electron microscopy. The results demonstrate that SLM is present and shows two different forms, lamellar bodies and lamellar layers. In the mucosae without endoscopic, histologic, and ultrastructural alterations we have found SLM when the tannic acid method has been used but not when the tissue has been fixed only in glutaraldehyde. Our results suggest that in children with ultrastructural alterations of the epithelium, the amount of gastric SLM is increased in respect to children with a normal mucosa and that the amount of SLM on the surface of the gastric antral mucosa is modified in pathologic conditions.

Adolescent↗
PubMed1992

Oral zinc as initial therapy in Wilson's disease: two years of continuous treatment in a 10-year-old child.

Two years of continuous therapy promoted a significant overall amelioration in a 10-year-old boy affected by an hepatic form of Wilson's disease in which zinc sulphate was the sole therapy. In particular, liver function returned to normal and hepatic histology also improved. The parameters characterizing copper metabolism were kept under good control, and a decrease in copper concentration was found in both erythrocytes and liver. The copper balance study performed during the 25th month of treatment showed that oral zinc was still efficiently inhibiting the intestinal absorption of copper. No side effects have been reported so far.

Administration, Oral↗
PubMed1990

Peptic disease in paediatric patients: a diagnostic and therapeutic contribution.

A retrospective clinical study was conducted in 267 children referred to the Verona University Institute of Paediatrics over the period from June 1985 to May 1989 for peptic symptoms. The aim was to obtain data on the incidence of peptic disease in paediatric patients and on the efficacy of various types of pharmacological active principles in treatment of the acute phase and of relapses. All cases observed were subjected to endoscopy (also combined with biopsy in cases presenting signs of inflammatory ulcer disease), which revealed the presence of mucosal abnormalities in 125 patients (46.8%), diagnosed as follows: oesophagitis (44 cases), gastritis and duodenitis (73 cases) and peptic ulcer (8 cases). Among the drugs used, ranitidine proved highly effective, producing healing in all cases reporting for follow-up, and showed excellent tolerability.

Adolescent↗
PubMed1982

Potential complications in the use of wheat bran for constipation in infancy.

A commercially available wheat bran preparation has been given to six infants between the ages of 6 and 16 months suffering from constipation not due to metabolic or anatomic causes. In all infants, normal bowel movements reappeared after a month of a diet containing bran. After a month on this diet, we observed the following: a decrease in blood levels of calcium, phosphate, and trace elements; an increase in fecal excretion of biliary salts and cholesterol; and an appearance of predominantly proteolytic fecal flora over the saccharolitic flora. These findings, especially the first one, indicate that bran preparations should be used in infancy with extreme caution because of possible side effect on the patient's nutritional status and growth. If bran is used, blood levels of minerals should be repeatedly checked in order to prevent the appearance of vitamin D-dependent rickets and the depletion of trace elements.

Constipation↗
PubMed1979

Gastric secretory function in coeliac disease.

Volume, total titrable acidity, total proteolytic activity and pepsin activity have been determined in 14 coeliac patients and in 8 controls of comparable ages and body weights. Basal secretion (B.O.), total outputs (T. O.) and peak outputs (P.O.) after pentagastrin injection have been determined. Peak outputs (values 60 min/kg) of these parameters are as follows: volume 5.0+/-1.7 ml in coeliacs, 4.3+/-1.2 ml in controls; total titrable acidity 406.1+/-155.0 mEq in patients, 296.1+/-182.4 in conttrols; total proteolytic activity 962.1+/-501.1 micronEq in coeliacs, 569.6+/-272.2 in controls; pepsin activity 789.1+/-521.8 micronEq in patients, 447.6+/-150.4 in controls.

Celiac Disease↗
PubMed1978

A simplified method for the evaluation of human faecal flora in clinical practice.

Qualitative and quantitative evaluation of aerobic and anaerobic faecal flora was determined by a new and easy method. 10 microliter of 12 ten-fold dilutions in saline of samples of faeces were plated on the surface of culture media solidified in wells of sterile virology plexiglass plates (diameter 16 mm; 0.5 ml culture media) and incubated at 37 degrees C for 24 h. The same dilutions and the same plexiglass plates were used under anaerobic conditions for analysis of anaerobic flora (under atmosphere of N2 85%, CO2 10%, H2 5%, negative pressure, at 37 degrees C for 48 h). The analysis was performed on 35 healthy breast-fed newborn infants, 1--6 days old. After birth, the meconium in sterile; already at 25 h of life some bacterial species (Lactobacilli, Bifidobacteria, Bacteroides) show the maximal concentration in faeces and do not grow afterwards; other bacterial species (Coliforms, aerobic and anaerobic Streptococci) increase gradually during the first week of life. This method gives the same results as the conventional techniques (i.e. Petri dishes), but in an easier and quicker way; therefore it seems useful in clinical practice.

Bacteria↗
PubMed1977

Persistent post-enteritis diarrhoea.

Clinical, biochemical, and gastroenterological data have been examined im 48 patients in two age groups, one under 12 months of age, the other between 12 and 30 months with persistent post-enteritis diarrhoea. In these patients, the illness consisted of chronic diarrhoea which followed acute enteritis. It brought about a mild malabsorption syndrome with impairment of growth, particularly in infants under one year of age. Chronic inflammation with mucosal damage due to alteration of the intestinal microflora by inappropriate diets and therapy seemed to be the cause of persistent diarrhoea in these patients.

Acute Disease↗
PubMedDate not supplied

[Congenital obstruction of the gastric antrum: description of a case].

On an average of 100,000 of livebirths congenital obstructive gastric syndromes range from 1 to 3 cases. The syndrome of the congenital antral membrane represents 5% of the total reported cases. It is mostly located 1 to 3 centimeters above the pylorus-duodenal connection and it may occur both in infants and toddlers. In very young patients it might be difficult to differentiate an hypertrophic stenosis of pylorus from a pyloric spasm. In older babies the obstacle to food passage may be moderate and the pathology may not be evident or it can be treated with simple medial therapy. This report presents the case of a 15 months old female with congenital antral membrane.

Female↗