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Biomedical subjects

A Deburge

Publications and source records attributed to A Deburge.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Treatment of lumbar disc herniation by chymopapain chemonucleolysis. A report on 120 patients.

Ninety of 120 patients with herniated lumbar discs who received an intradiscal injection of chymopapain achieved successful recovery. Sixteen of the 21 patients who underwent subsequent surgery had a good result. Study of the unsuccessful cases showed that disc sequestration and lateral stenosis were the major organic causes of failure. Certain radiologic criteria suggestive of sequestration and of important segmental stenosis are described. They appear to be a contraindication to chemonucleolysis. Psychogenic pain components and the failure of the enzyme to hydrolyse the nuclear proteoglycans in a few cases were the other two causes of poor results. A survey of postchemonucleolysis computed tomographic scans suggested that, although capable of digesting nuclear material in most cases, chymopapain may also work through an "anti-inflammatory" mechanism.

Adult↗
PubMedDate not supplied

The diagnosis of disc sequestration.

Sequestration of a disc herniation is an important cause of failure of chemonucleolysis. It therefore is important to recognize this particular variety of disc herniation before considering enzymatic discectomy. In order to determine the clinical and myelographic signs of sequestration, we reviewed the charts, myelograms, and surgical findings of 98 patients operated on for a disc herniation. A correlation was made between the three anatomic types of disc herniation found during surgery and the clinical and myelographic signs observed preoperatively. No characteristic clinical sign was found. No pathognomonic myelographic features were discovered. However, when the myelographic defect appears irregular and at a distance from the disc space, sequestration should be highly suspected.

Humans↗