Search PubMed⌕ Search

Biomedical subjects

A Dean

Publications and source records attributed to A Dean.

At least 19 recordsLinked to original sources
PubMed1992

Sarcomas of the head and neck.

Fourteen cases of sarcomas involving the head and neck over a period of 15 years were reviewed. The male to female ratio was 3.5:1. Mean age of occurrence was 33.4 years, with a range of 5-84 years. Soft tissue was the site of origin in three cases, maxilla in four and mandible in seven patients. Radical surgery with resection of adequate disease-free margins was the most effective mode of treatment. Radiotherapy and chemotherapy was used in selected cases. Recurrence occurred in 42.9% of patients, and was the main cause of death. Three patients (21.4%) developed distant metastases. The actuarial 2-year and 5-year survivals of the 14 patients assessed were 64% and 56% respectively.

Adolescent↗
PubMed1992

Continuing your education ... with CATS.

MIKE McMANUS and ANNE DEAN discuss the credit accumulation and transfer scheme (CATS) and consider many of the common questions regarding the system: how to accredit current professional qualifications; use of credited learning, and potential continuing education pathways open to health visitors. Finally, the authors discuss the validity of such awards.

Education, Nursing, Baccalaureate↗
PubMed1992

Comparison of frequencies of suicidal tendencies among patients receiving fluoxetine, lofepramine, mianserin, or trazodone.

To evaluate whether fluoxetine causes an important increased risk of suicidal behavior, we compared the frequency of attempted suicide, suicidal ideation, and aggressive behavior in persons who received fluoxetine, lofepramine, mianserin, and trazodone, based on information available on general practitioners' computers provided by Value Added Medical Products, Ltd. The frequency of these events was higher in fluoxetine users in the year prior to first treatment than in users of the other three antidepressants. The frequency of these events in the 90 days after the study drug was started was similar for the users of all four drugs. These data indicate that fluoxetine does not directly cause suicidal behavior at a substantially higher frequency than do lofepramine, mianserin, and trazodone.

Adolescent↗
PubMed1991

How common are epileptic seizures in old age?

A large primary-care computerized database was searched to determine the incidence and prevalence of epilepsy and epileptic seizures in old age compared with the general population. The prevalence of subjects with a diagnosis of epileptic seizures was higher in older age groups: 10.9/1000 for sexagenarians, 12.0 for septuagenarians and 13.1 for those over 80, compared with 9.0/1000 in the overall population. The overall prevalence in subjects aged over 60 was 11.8. Annual incidence rose even more sharply in old age: 76/100,000 for sexagenarians, 147 for septuagenarians, and 159 for those over 80, compared with an overall population incidence of 69/100,000. The overall incidence in subjects over 60 was 117. Of incident cases requiring treatment, 35.5% were over 60 years old. Our findings are in keeping with other recent epidemiological studies and in part reflect the age-associated increase in the prevalence of cerebrovascular disease. They have implications for the organization of services for elderly people, for the education of general practitioners and hospital doctors and for directing epilepsy research.

Aged↗
PubMed1991

The recognition and non-recognition of problem-solving stages in nursing practice.

A requirement for high-quality individualized nursing care is that nurses must recognize and attempt to solve patients' health problems. In this study, it was decided to investigate problem solving using a model similar to the nursing process derived from the general literature. Insight into nurses' perceptions and understanding of problem solving was gained by interviewing 116 nurses using vignettes of clinical problem solving. Data analysis revealed that many informants failed to discuss some problem-solving stages, in particular planning and evaluation. Conversely, problem assessment and implementation attracted more comment. The implications for these variations in nurses' problem-solving behaviour are examined in relation to contemporary nursing issues.

Humans↗
PubMed1991

Transcriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoter.

The epsilon-globin gene is the first of the human beta-like globin genes to be expressed during development. We have analyzed protein-DNA interactions in the epsilon-globin promoter region by DNase I footprinting and electrophoretic mobility shift experiments using nuclear extracts from K562 human erythroid cells and from nonerythroid HeLa cells. A restricted set of ubiquitous proteins, including Sp1, bound to regions of the promoter including the CACCC and CCAAT sites. Three interactions, at positions -213, -165, and +3 relative to the transcription start site, were erythroid specific and corresponded to binding of GATA-1, a transcription factor highly restricted to the erythroid lineage. Interestingly, the GATA-1 site at -165 has been conserved in the promoters of 10 mammalian embryonic globin genes. Point mutations demonstrate that GATA-1 binding to this site is necessary for interaction with an erythroid-specific enhancer but that in the absence of an enhancer, GATA-1 does not increase transcription.

Animals↗
PubMed1991

[Pilomatrix carcinoma. A new case].

We present a new case of Pilomatrix Carcinoma after having review the 22 cases previously published. The tumor arisen in a 74 years old male, in the left preauricular region. The lesion was excised with wide margins. A year after there is not any evidence of recurrence or metastases.

Aged↗
PubMed1990

Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

The yeast alpha 2 repressor suppresses expression of a-mating-type-specific genes in haploid alpha and diploid a/alpha cell types. We inserted the alpha 2-binding site into the multicopy TRP1/ARS1 yeast plasmid and examined the effects of alpha 2 on the chromatin structure of the derivative plasmids in alpha cells, and a/alpha cells. Whereas no effect on nucleosome position was observed in a cells, nucleosomes were precisely and stably positioned over sequences flanking the alpha 2 operator in alpha and a/alpha cells. In addition, when the alpha 2 operator was located upstream of the TRP1 gene, an extended array of positioned nucleosomes was formed in alpha cells and a/alpha cells, with formation of a nucleosome not present in a cells, and TRP1 mRNA production was substantially reduced. These data indicate that alpha 2 causes a positioning of nucleosomes over sequences proximal to its operator in TRP1/ARS1 chromatin and suggest that changes in chromatin structure may be related to alpha 2 repression of cell-type-specific genes.

Gene Expression Regulation, Fungal↗
PubMed1990

Effects of social support from various sources on depression in elderly persons.

Although global measures of social support demonstrate significant effects on psychological and physical well-being, the differential significance of various support sources is largely unknown. The present study examines differences in the effects of functional expressive support by source on depressive symptoms. This approach is contrasted with network interaction studies of elderly persons, which do not measure functional support but do suggest that friends are distinctly significant. Spouse, friends, and adult children were found to rank in descending order of importance; relatives show no effect. Low support may have stronger effects than unavailability of sources. Effects of supports and stressors are not conditioned by age, sex, or widowhood. Implications of findings and further research needs are discussed.

Aged↗
PubMed1990

[Occult tumors of the parotid gland and facial paralysis. A diagnostic problem].

The facial palsy produced by a parotid tumour, could be misdiagnosed due to the absence of a palpable mass or other any signs in the computerized axial tomography or nuclear magnetic resonance. However there are data derived from the facial anatomy, course and clinical characteristics from the palsy that could make us thinking on the presence of a parotid tumour. The objective of this article is to present this characteristics, together with a serial of clinic cases which coursed in the beginning with a facial palsy and had problems in their diagnostic. It's also remarked the significance of the presence or not of perineural infiltration to the parotid tumours that will condition not only the prognosis but also the clinic course.

Aged↗
PubMed1989

Effect of transforming growth factor-beta 1 on proliferation and induction of hemoglobin accumulation in K-562 cells.

The effects of transforming growth factor-beta 1 (TGF-beta 1) on proliferation and hemoglobinization in K-562 cells, a human multipotential hematopoietic cell line, were studied. We found that TGF-beta 1 could induce hemoglobin accumulation in K-562 cells. Various clones were selected on the basis of the inducibility of hemoglobinization by TGF-beta 1. One high response clone (no. 1) and one low response clone (no. 8) were studied in detail. Hemoglobin accumulation peaked on day 5 of culture in the presence of TGF-beta 1 (0.5 ng/mL, 20 pmol/L), when 90% of clone 1 cells, 55% of parent line cells, and less than 10% of clone 8 cells contained hemoglobin. There was a concomitant reduction in proliferation of 60% for clone 1, 40% for the parent line, and 30% for the clone 8 on day 5 of culture. Quantitative analysis showed that the hemoglobin contents in clone 1 after 5-day induction by TGF-beta 1 and hemin were 1.0 pg/cell and 2.9 pg/cell, respectively. The hemoglobin induced by TGF-beta 1 showed the same electrophoretic characteristics as the hemoglobin induced by hemin. The expression of epsilon-globin mRNA was minimally detectable in control cells and was induced in both TGF-beta 1 and hemin treated cells. Other cytokines with potential effects on K-562 cell proliferation and differentiation were also studied. Interleukin-1, interleukin-3, interferon alpha, interferon gamma, and inhibin, tested as single agents, showed minimal effects on proliferation. None of these agents could induce hemoglobinization or inhibit the hemoglobinization induced by TGF-beta 1.

Cell Differentiation↗
PubMed1989

Measuring the communication of social support from adult children.

Further knowledge of the nature and significance of the relationships of elderly persons to their adult children requires the application of social support scales tapping the quality and content of their interactions. Scaling efforts must further address conceptual and operational specification, the differentiation of sources and dimensions of support, the objectification of self-report scales, and construct validity. Respondents to this survey are a community, stratified probability sample of adults aged 50 and older (N = 1,174). Measures employed include 2 items reflecting instrumental support and 17 items designed to tap Cobb's (1976) definition of expressive support as consisting of information that one is loved, esteemed, and embedded in a social relationship characterized by mutual caring and obligation. Factor analyses consistently discern one instrumental and three expressive dimensions of support: Caring and Concern, Social Integration, and Love and Affection. These subscales are differentially correlated with sociodemographic characteristics of the parents and adult children, as well as with depression and disability. Implications of these and other findings are discussed.

Adult↗