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Biomedical subjects

A DePalma

Publications and source records attributed to A DePalma.

6 recordsLinked to original sources

Prostate Cancer Shared Decision: a CD-ROM educational and decision-assisting tool for men with prostate cancer.

Prostate Cancer Shared Decision, a CD-ROM program produced with the guidance of leading prostate cancer specialists, educates prostate cancer patients and suggests possible treatments. As the first portable, interactive prostate cancer decision-making tool, Prostate Cancer Shared Decision offers expert, plain-language explanations of prostate anatomy, cancer diagnosis, and treatment options. Through answers to lifestyle and attitude questions entered into a series of user-friendly questionnaire screens, Prostate Cancer Shared Decision helps patients understand their disease and feel comfortable with their treatment decision. This type of educational tool is representative of the new technology that is becoming available to patients with prostate cancer.

CD-ROM↗

M.D.-Ph.D. degrees.

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Clinical Medicine↗

Isolation of 2-fluorocitrate produced by in vivo dealkylation of 29-fluorostigmasterol in an insect.

A novel pro-insecticide, 29-fluorostigmasterol, is proposed to cause mortality due to release of fluoroacetate during side chain dealkylation. The 29-3H-labeled substrate was fed to third instar tobacco hornworms (Manduca sexta) and erythro-2-fluoro-[2-3H] citrate was isolated in 0.012% yield by ion-exchange, silica gel, and reverse-phase chromatography of the tricarboxylic acid, trimethyl ester, and trimethyl ester benzoate, respectively. The less toxic 29-fluoro-[29-3H]sitosterol did not provide sufficient labeled fluorocitrate to allow isolation, while a more toxic 16-3H-labeled 16-fluorofatty acid gave nearly 1% conversion to labeled fluorocitrate. This is the first direct chemical evidence for the fate of the two carbons removed during phytosterol dealkylation in an insect. It is also the first use of labeled fluoroacetate precursors to identify labeled 2-fluorocitrate as an in vivo metabolite of these precursors.

Chromatography, High Pressure Liquid↗

Ankylosing spondylitis.

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Agglutination Tests↗