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Biomedical subjects

A De Schepper

Publications and source records attributed to A De Schepper.

At least 109 records · Page 6Linked to original sources
PubMed1979

Hepatic artery aneurysm: a pitfall in biliary surgery.

This paper describes a patient operated upon for gall-bladder and bile duct stones, who presented with an extrahepatic aneurysm of the main hepatic arterial trunk and with a central intrahepatic haematoma assumed to be caused by the rupture of an intrahepatic aneurysm or by secondary intrahepatic necrosis. Exploration of the bile ducts resulted in haemobilia. The presence of extrahepatic arterial collaterals precluded individualization of the left and right hepatic arteries and subsequent distal arterial ligation or partial hepatectomy. Ligation of the common hepatic artery, although initially successful, was insufficient to avoid a recurrent and fatal haemobilia.

Aged↗
PubMed1979

Effects of intravenous and oral domperidone on the motor function of the stomach and small intestine.

One hundred and fifty-six patients referred for barium meal with follow-up examination, participated in a placebo-controlled blind assessment of the effects of domperidone against placebo, on gastric motility and emptying. None of the patients had organic obstruction, had undergone previous gastrointestinal surgery or were currently taking anticholinergic drugs. In one study, patients were randomly given either 10 mg, 20 mg or 50 mg of domperidone or placebo suspension orally 30 minutes prior to barium meal to simulate therapeutic conditions. In a separate study conducted under identical conditions, either 8 mg domperidone or placebo was given intravenously. Domperidone (8 mg i.v. or 20 and 50 mg orally) significantly promoted antral peristalsis and gastric emptying compared to placebo. The results suggest that domperidone improves motor function in the proximal part of the gastrointestinal tract and synchronizes motor function due to its protracted activity.

Administration, Oral↗
PubMed1978

[Our experience of the Vest-Margulis test in the differential diagnosis of mechanical and paralytic ileus (author's transl)].

In order to evaluate the Vest-Margulis test in the differential diagnosis between mechanical and paralytic ileus a retrospective study was undertaken on 51 such tests performed before and after operation. Transit of gastrografin (Sodium amidotrizoate) through the caecum 4 hours after ingestion was controlled through roentgenograms. The diagnostic value of a positive test in pure paralytic ileus can be confirmed. Indeed 23 positive cases proved to have paralytic rather than mechanical ileus. On the contrary a negative test has no diagnostic value. Twenty-eight patients in which the contrast medium had not reached the caecum within 4 hours had either form of intestinal obstruction. The attention is drawn on the interesting therapeutic action of gastrografin in patients with a paralytic ileus and the simplicity of the investigation.

Cecum↗
PubMed1978

Effects of oral domperidone on gastric emptying and motility. A double-blind comparison with placebo and metoclopramide.

The effects of an oral treatment with domperidone on the gastric motor function were investigated in a double-blind study, including 129 patients, referred to the department of radiology for barium meal examination. None of them had an organic obstruction or had had previous gastrointestinal surgery. The patients received either domperidone (50, 20 or 10 mg), metoclopramide (20 mg) or a placebo. The medication was given 30 min before the intake of the barium meal in order to stimulate therapeutic conditions. During the barium meal examination, an assessment was made of the peristaltic activity of the antrum, the gastric emptying and the small bowel transit time. As to these parameters, 50 mg and 20 mg domperidone and 20 mg metoclopramide were significantly superior to the placebo.

Adolescent↗
PubMedDate not supplied

Comparison of MRI features of different grades of DCIS and invasive carcinoma of the breast.

The purpose of the study is to compare mammography and magnetic resonance (MR) mammography in detection and assessment of extent, of histologically proven ductal carcinoma in situ (DCIS) and to compare MR features of DCIS, with features of invasive carcinoma. Forty histopathologically proven and MR detected pure DCIS lesions were described and compared with 213 enhancing invasive carcinomas. Histopathological examination revealed 49 pure DCIS, MR detected 40 of them (81.6%). There was a good correlation between diameter measured on mammography, MR and histopathology. MR was able to detect additional foci. Ductal enhancement, a focal area or a mass were perceived in respectively 8 (20%), 8 (20%) and 24 (60%) DCIS and in 0, 6 (2.8%) and 207 (97.2%) invasive lesions. Maximal contrast enhancement after 3 minutes was seen in 60.9% of DCIS and before 3 minutes in 61% of invasive masses. Signal intensity increase of more than 100% was seen in 76.9% of DCIS and in 91.1% of invasive carcinomas. DCIS had a wash out in 53.8% and invasive carcinomas in 65.3%. MR was able to detect 81.6% of DCIS. Diameter prediction was good on mammography and MR mammography. The only MR feature exclusively seen in DCIS was ductal enhancement.

Aged↗