No nurses in operating theatres?
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Nurses↗
Biomedical subjects
A Davidson
Publications and source records attributed to A Davidson.
Effect of surgical trauma on 7, 12-dimethyl benzanthracene induced breast cancer in the Sprague-Dawley rat.
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Animals↗
Comparison of clear corneal and corneoscleral cataract incisions.
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Cataract Extraction↗
Digital read-out device for blind people.
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Blindness↗
An Account of the Madagascar Ordeal Poison.
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Journal Article↗
Notice of a Case of Malposition of the Right Kidney.
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Journal Article↗
Familial occurrence of discrete subaortic membrane.
The first case of multiple family members with discrete subaortic membrane and no other congenital defects is presented. One family member presents with findings suggesting a forme fruste of this disease. Increased surveillance of family members of individuals with discrete subaortic membrane is warranted, as the clinical findings of mild subaortic obstruction may be indistinguishable from those of an innocent flow murmur.
Adult↗
Idiotypic analyses of anti-DNA antibodies in systemic lupus and monoclonal gammopathy.
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Antibodies, Anti-Idiotypic↗
Management and counseling of children with inherited metabolic disorders.
Although rare individually, as a group inborn errors of metabolism are relatively common in the pediatric population. Families need assistance with evaluation and referral, accurate counseling, and management issues. An overview of inherited metabolic disorders is presented, followed by discussion and examples of selected categories of disease.
Child↗
[Echocardiography diagnosis of total anomalous pulmonary venous drainage in the neonatal period].
A 20-days-old female newborn was referred to our hospital because of persistent respiratory distress and a mild central cyanosis. On echocardiography from the suprasternal notch all 4 pulmonary veins could be visualized entering a common chamber posterior to the left atrium. This chamber communicated with a left vertical vein which drained through a large innominate vein into the right superior vena cava. The diagnosis of supracardiac type of TAPVD was confirmed the following day by angiography. The child was successfully operated and the postoperative course was uneventful. Cardiac catheterization carries an increased risk in patients with TAPVD in case of pulmonary hypertension due to pulmonary-venous obstruction. In experienced centers echocardiography has become the definite diagnostic method with a high level of sensitivity and specificity in patients with atrial sitlus solitus, unifocal pulmonary venous connection, and no evidence of other major congenital cardiac defects. With continuously improving knowledge an increasing number of newborns will benefit from improved ability to perform surgical repair without prior cardiac catheterization.
Blood Flow Velocity↗
Quantitative videofluoroscopic evaluation of pharyngeal function in the dog.
Videofluoroscopic evaluation of both liquid barium and barium soaked kibble was performed in 11 adult, clinically normal dogs of varying breeds. Each examination was digitized and evaluated frame by frame to establish the normal timing sequence of the pharyngeal phase of swallowing. Closure of the epiglottis was considered the onset of swallowing. The time to each of the following events was recorded: (1) Maximum pharyngeal contraction, (2) Opening of the epiglottis, (3) Opening of the cranial esophageal sphincter, and (4) Closure of the cranial esophageal sphincter. These values were found to be consistent both intra and interpatient. Retrospective analysis of 3 videofluoroscopic examinations from dogs that met the subjective criteria defining cricopharyngeal achalasia was then performed. A statistically significant delay in the time to opening and closure of the cranial esophageal sphincter was found employing both liquid barium and barium soaked kibble in the dogs with cricopharyngeal achalasia.
Animals↗
Nasal aspergillosis: treatment with clotrimazole.
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Administration, Topical↗
New bone formation in acromegaly: pathogenetic implications for diffuse idiopathic skeletal hyperostosis.
Radiographs of spinal and heel entheseal areas and the skull were examined for new bone formation in 30 acromegalic patients. Forty-seven percent satisfied accepted criteria for Diffuse Idiopathic Skeletal Hyperostosis (DISH), 67% had marked heel enthesopathic change and 87% had Hyperostosis Frontalis Interna (HFI). Such hyperostotic changes were indistinguishable from those seen in DISH and the extent and degree of such changes increased with duration of acromegaly. It is proposed that a common metabolic factor, e.g., hyperinsulinaemia, may be responsible for the hyperostotic changes seen in both DISH and acromegaly.
Acromegaly↗
Effects of retinoic acid on cell differentiation and reversion toward normal in human endometrial adenocarcinoma (RL95-2) cells.
BACKGROUND: All-trans retinoic acid is currently used in clinical trials in combination with tamoxifen to treat breast cancer, and 13-cis retinoic acid is used with a-interferon to treat metastatic endometrial cancer. We examined the effects of all-trans retinoic acid and 13-cis RA alone on endometrial adenocarcinoma (RL95-2) cells to investigate the cell biological mechanisms by which retinoic acid may reduce the metastatic phenotype and induce differentiation. METHODS: RL95-2 cells were seeded onto 4-chamber plastic slides and treated with 13-cis retinoic acid or all-trans retinoic at 0.5 microM, 1 microM and 5 microM doses for 90 minutes at 37 degrees C and stained for F-actin. RESULTS: Untreated RL95-2 cells exhibited staining of disrupted aggregates of F-actin only near the cell periphery. Cells treated with the three doses of 13-cis retinoic acid exhibited a dramatic reorganization of F-actin throughout the cells. When cells were treated with 0.5 microM all-trans retinoic acid, actin filaments reorganized. Cells treated with 1 microM all-trans retinoic acid and 5 microM all-trans retinoic acid displayed increased organization of F-actin and cell size increased. The percentage of S-phase cells increased at the high doses of retinoic acid treatment. This effect was apparently transient, since retinoic acid did not significantly affect cell growth. CONCLUSION: An organized cytoskeleton and an increase in cell size are associated with differentiation. We suggest that retinoic acid exerts its effects on these transformed cells by reorganizing actin filaments, and inducing differentiation, thus inducing a more stationary phenotype.
Actins↗