Should I have given a dying patient a drink?
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Biomedical subjects
Publications and source records attributed to A David.
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We studied 22 patients undergoing total intravenous anaesthesia for both abdominal and superficial surgery. Anaesthesia has been induced and maintained with propofol (1 mg/kg in 20 seconds; 10 mg/kg/h for 10 minutes; 8 mg/kg/h for 10 minutes; 6 mg/kg/h until the end of the operation) and alfentanil (15 mg/kg before the induction and boli of 10-30 mg/kg in the presence of insufficient surgical analgesia). All the patients have been intubated after the administration of vecuronium 0.1 mg/kg, and artificially ventilated with air and oxygen (FiO2 0.4). We observed: 1) haemodynamic stability after the intubation and during surgery; 2) easy control of surgical analgesia; 3) early postoperative recovery, with no correlation with the doses of propofol and alfentanil; 4) absence of postoperative respiratory depression; 5) intraoperative amnesia; 6) low incidence of postoperative side effects. We conclude that, by virtue of the pharmacokinetic characteristics of propofol and alfentanil, most limitations of total intravenous anaesthesia have been overcome.
Sedation with propofol was achieved in 10 patients with COPD admitted into ICU because of acute respiratory insufficiency. Propofol dosage was 1-3 mg/kg-1/h and the testing period 30-144 h. Curarization was non required. Sedation with propofol, valued by means of Ramsay Score, was suitable in all tested patients. Bio-humoral and instrumental monitoring have not evidenced side effects.
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A simple and safe procedure is proposed to manage cases of "empty sella" complicated by rhinorrhea. It is performed under fluoroscopic control only by introducing a needle in the sphenoid sinus via a transnasal route and by injecting fibrin glue into the sinusal cavity. This procedure requires a short hospitalization and it allows to avoid the compliances of other techniques.
Clinical manifestation of fibromuscular angiodysplasia of the lower extremities is often due to a spastic phase of the arteries, and may be severe enough to present as Raynaud's phenomenon. We describe a 37-year-old woman who suffered for a year from numbness and coldness of the foot and claudication over 30 meters. Angiography revealed fibromuscular angiodysplasia of the left superficial femoral artery, right anterior tibial artery and spastic changes in the peroneal artery. Phenol sympathectomy of the third lumbar ganglion resulted in dramatic relief of symptoms.
Atherosclerotic aneurysms of the iliac artery shows a marked tendency to rupture, usually with fatal outcome. A ruptured aneurysm of the left iliac artery in a 76-year-old man was successfully treated by removing the aneurysm and implanting an 8 mm dacron tubular prosthesis as a subcutaneous femoro-femoral crossover graft. The operative technique is described. The advantages of this bypass techniques as the treatment of choice in such cases are discussed.
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We report the case of 5 year-old boy, presenting with acute pericarditis, wandering abdominal tumefaction and high eosinophil blood count. Clinical history and serologic tests arrived at the diagnosis of human hypodermyiasis. Pericardiac manifestations are so scarce in this kind of parasitosis, that we found of interest to relate a new case.
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Thrombosis of the axillary vein occurred in two patients following creation of an arteriovenous fistula for hemodialysis. The thrombosis developed before the fistula was used for dialysis, and was demonstrated by venography. Treatment in both cases involved anticoagulant therapy and ligation of the fistula; both patients experienced relief of pain and swelling, although the collateral venous congestion remained unchanged. This complication of arteriovenous fistula creation has not been previously described, probably because thrombosis does not usually occur in a high venous flow state.
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