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Biomedical subjects

A Danysz

Publications and source records attributed to A Danysz.

70 records · Page 4Linked to original sources
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Studies on the cause of changes of reactivity to hexobarbital in spontaneously hypertensive rats (SHR).

The hypnotic action of hexobarbital is weaker in spontaneously hypertensive rats (SHR) than in Wistar rats. The difference does not appear in young rats (up to the sixth week of life) and appears gradually concomitantly with maturation of animals. There was no correlation between the changes of reactivity to hexobarbital and development of hypertension. The rate of metabolism of hexobarbital was similar in SHR and Wistar rats. There is a close relationship between the changes in reactivity to hexobarbital and psychomotor activity: both are significantly higher in SHR than in Wistar rats. The results suggest that the main cause of a weaker action of hexobarbital in SHR is higher intensity of stimulatory processes in the central nervous system.

Aging↗
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Effect of some peptides on distribution of rifamycin SV in rabbits.

The effect of insulin, glutathione, trypsin and somatotropin on processes of distribution and elimination of rifamycin SV were investigated using pharmacokinetic analysis. It was found that the peptides, especially glutathione and trypsin, enhance the distribution of rifamycin in rabbits and cause an increase of amount of this antibiotic in the central compartment.

Animals↗
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[Tymoanaleptic drugs].

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Antidepressive Agents↗
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Dependence of pentobarbital kinetics upon the dose of the drug and its pharmacodynamic effects.

Pentobarbital (PB), at dose range of 20--50 mg/kg, displays in rabbits non-linear, dose-dependent kinetics. Pharmacokinetics parameters of drug elimination depend largely upon the dose, while the distribution phase is dose-independent. The rate of disappearance of PB from the central compartment (plasma) decreases with the increase of the dose. The analysis of pharmacodynamic parameters has shown that this dose-dependent retardation of PB elimination is probably caused by an impairment of metabolic processes, resulting from disturbance of the circulatory system. A close correlation has been found between the hypotensive effect of PB and the elimination constant, k13, and also between the hypotensive effect and beta.Vd(extrap), a coefficient proportional to the rate of metabolism of PB [23, 29]. The results indicate the necessity of considering the changes in the functional state of the organism, related to the action of a drug, in pharmacokinetic studies.

Animals↗
PubMedDate not supplied

The effect of glutathione on 6-mercaptopurine pharmacokinetics in rabbits.

Plasma concentration of 6-mercaptopurine (6-MP) after iv administration of the drug is proportional to the dose in the range from 25 to 100 mg/kg, and the course of the time curve corresponds with a three-compartment open model. Glutathione (GSH) depresses the 6-MP level in plasma; a dose of 10 mg/kg of GSH elevates the concentration in shallow peripheral compartment and prolongs t0.5. A dose of 20 mg/kg depresses the 6-MP concentration in all compartments. The results indicate that 6-MP distribution in the body may be changed by GSH .

Animals↗
PubMedDate not supplied

Influence of coenzyme Q-10 on the hypotensive effects of enalapril and nitrendipine in spontaneously hypertensive rats.

Administration of coenzyme Q-10 (10 mg/kg) once a day for 4 weeks decreased the arterial blood pressure in SHR's. Enalapril and nitrendipine administered in a single dose caused significant decrease of blood pressure. Application of enalapril and nitrendipine to rats chronically pretreated with coenzyme Q-10 revealed, that the maximal hypotensive effect was not greater, but it lasted much (ca. 2-times) longer. Independently of mechanism of this interaction it may be suggested that the chronic administration of coenzyme Q-10 would create the possibility of significant decrease of the frequency of some antihypertensive drug administration.

Animals↗