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Biomedical subjects

A Danek

Publications and source records attributed to A Danek.

70 records · Page 4Linked to original sources
PubMed1978

The use of computers in pharmacokinetics.

A review of computer applications is presented, and several examples of the use of analog and digital computers are given. Special attention is given to fitting the time concentration data to the one, two or more exponential equations, for estimation of pharmacokinetic parameters, for dosage regimen of drugs and for evaluation of bioavailability.

Biological Availability↗
PubMed1976

A simple electronic circuit for simulation of pharmacokinetic processes.

A simple electronic circuit is constructed for simulation of the theoretical curves associated with single and multiple dosing kinetics. The output is an analog device which generates plasma concentration curves versus time, consistent with the assumption in a one-compartment open model with rapid intravenous injection or first-order absorption. Potentiometer settings offer variations in dosing schedules, distribution volumes as well as in absorption and elimination rate constants. All details are made from standard electronic components. The device can be used in teaching of the elements of pharmacokinetics.

Computers, Analog↗
PubMed1975

Studies on absorption and elimination of drugs. Part VI: Fitting of a double exponential curve to the observed drug concentration after single extravascular administration.

A simple program was written in Algol 1204 for the Polish digital computer ODRA 1204. It permits the fitting of the Bateman equation C equals const [e-KEt -- e-KAt] or the equation C equals Be-KEt -- Ae-KAt to the observed plasma or serum concentration data after single extravascular administration of a drug. The results obtained with this M-31 program, compared with the calculations of the pharmacokinetic parameters for tetracycline HCl obtained with the Wagner's Nonline or Lag Time program, show a good conformity.

Absorption↗
PubMedDate not supplied

Pharmacokinetic investigations of Craviten. I. Spectrofluorometric determination of the drug in biological material.

A spectrofluorometric method for the quantitative determination of Craviten in serum, tissues and urine is described. The fluoroscence spectrum of that compound in acetic acid solution at excitation and emission wavelengths 270/380 nm respectively, is determined. A linear relationship between fluorescence and concentration exists over the range 0.25-10 microgram/ml and concentration of the drug as small as 0.15 microgram/ml may be determined.

Animals↗
PubMedDate not supplied

Pharmacokinetic investigations of Craviten. II. Dose-dependent elimination kinetics in rats following rapid intravenous injection.

Serum and urine levels of iv administered Craviten were determined. Comparison of the decline of the same absolute and relative serum concentrations of the drug and the variation of pharmacokinetic parameters with the dose leads to the conclusion, that the elimination of Craviten in rats cannot be described by first-order kinetics. The amount of the drug found in urine indicates, that the fraction of Craviten eliminated in the intact form is about 1.27 per cent of the iv administered dose.

Animals↗
PubMedDate not supplied

Pharmacokinetic investigations of Craviten. IV. First-pass metabolism in rats.

Pharmacokinetic analysis of serum levels of Craviten found after oral and iv injection suggests, that the examined drug has a relatively low systemic availability. This lack of availability may be attributed to the metabolism of Craviten during the first passage into the circulation after oral administration.

Administration, Oral↗