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Biomedical subjects

A Damiani

Publications and source records attributed to A Damiani.

36 records · Page 2Linked to original sources
PubMedDate not supplied

[Subacute sclerosing panencephalitis in adults. Anatomo-clinical illustration in 1 case].

A 23 years old man suffering from SSPE died 18 months after the onset of the disease. The clinical picture, EEG and immunological tests were typical for SSPE, and so was the anatomo-pathological investigation; the only difference was that the Cowdry type A inclusion bodies were absent. The peculiarity of this case consists in the fact that the disease appeared in an adult. In the literature we found very few cases of SSPE with such a late onset.

Adult↗
PubMedDate not supplied

Circadian rhythm of the PRL response to TRH in healthy subjects.

The PRL response to TRH constitutes an important clinical tool for diagnosing forms of hyperprolactinemic syndrome. Hence it is important to establish the characteristics of the circadian variation in the response of PRL to TRH to improve the diagnostic value of the test. Six male subjects, ranging in age from 23 to 24 years, participated in this study. All were considered healthy on the basis of clinical examination, biochemical and hormonal tests. Six TRH tests were performed on each subject, one test every other day during a total span of 12 days. Each test was performed at a different clock hour: 0000, 0400, 0800, 1200, 1600, 2000. For the test, subjects received 200 microgram TRH intravenously. Blood samples were drawn from a catheterized arm vein before the TRH injection (basal value) and 20, 30, 60 and 120 min after injection. At each timepoint 5 endpoints were determined for PRL on each subject. The population mean cosinor, according to Halberg, was used to investigate the circadian rhythm in each of the endpoints. All the 5 endpoints for PRL are consistent on showing p values near 0.5 and acrophase estimates before midnight (while basal value displays acrophase at 0400). Further investigations are necessary to clarify these circadian rhythms and the shift of the acrophases.

Adult↗