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Biomedical subjects

A D Wright

Publications and source records attributed to A D Wright.

At least 145 records · Page 8Linked to original sources
PubMed1978

Renal disease.

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Humans↗
PubMed1978

Viral hepatitis.

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Hepatitis↗
PubMed1978

Diabetes mellitus and coeliac disease: a clinical study.

Fourteen adults in whom diabetes mellitus and coeliac disease coexist, are described. In no patient was coeliac disease diagnosed (biopsy proven) before the age of 28 years. Diabetes was recognized before coeliac disease in all except one. Diabetic control was very unstable and hypoglycaemia particularly troublesome before treatment with a gluten free diet. Following gluten restriction, insulin requirement increased in six patients, and diabetic control became more stable. Diarrhoea due to coeliac disease in a patient with coexisting diabetes, may be mistakenly diagnosed as 'diabetic diarrhoea'. However, certain clinical and laboratory features should arouse suspicion that the diarrhoea is not of diabetic origin. These included a history of gastrointestinal symptoms preceding the diagnosis of diabetes, the occurrence of repeated hypoglycaemia, absence of neuropathy, anaemia, low serum folate, low serum albumin and a malabsorption pattern on small bowel radiography. A definitive diagnosis of coeliac disease can be made only jejunal biopsy. The opportunity to diagnose coeliac disease in adult diabetics will usually fall to the diabetologist and wider use of jejunal biopsy in diabetics with chronic or recurrent diarrhoea is suggested.

Adult↗
PubMed1977

Obesity.

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Body Weight↗
PubMed1977

Diabetes.

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Age Factors↗
PubMed1977

The effect of cigarette smoking on blood sugar, serum insulin and non esterified fatty acids in diabetic and non diabetic subjects.

The effect of cigarette smoking on carbohydrate metabolism has been investigated in 10 diabetic and 18 non-diabetic subjects. All were habitual smokers. Neither the fasting plasma sugar nor the plasma sugar response to an oral glucose load was significantly altered by smoking. Serum insulin, free fatty acids, cholesterol and triglyceride were measured in 10 non-diabetic patients, and were not significantly altered by smoking. It is concluded that in habitual smokers at least, cigarette smoking does not impair carbohydrate metabolism. In addition, it seems that smoking before or during oral glucose tolerance test is unlikely to influence the diagnostic value of the test.

Adult↗
PubMed1977

Changes in systolic time intervals during treatment of diabetes mellitus.

The cardiovascular response to the control of diabetes by sulphonylurea drugs has been investigated using systolic time intervals in a group of 19 diabetics. Before treatment a significantly greater heart rate and shortening of QS2 interval and left ventricular ejection time index were encountered among the more hyperglycaemic diabetic patients requiring drug therapy while all diabetics had a reduction of pre-ejection period index. There was a gradual return of resting heart rate and systolic time intervals to control values along with the fall in plasma sugar concentration during treatment. A likely explanation of the findings is that uncontrolled diabetics, particularly those more severely affected, are subjected to an increased adrenergic stimulus to the cardiovascular system which disappears with therapy. There is no evidence of positive inotropic action of sulphonylurea drugs in this study.

Blood Glucose↗
PubMed1976

A study of pituitary function in patients with idiopathic hemochromatosis.

Pituitary function was assessed in twelve male patients with idiopathic hemochromatosis. Though clinical features suggestive of hypogonadism were noted in nine cases, impaired pituitary function was demonstrated in only two instances. Our findings suggest that factors other than pituitary or testicular failure contribute significantly to the occurrence of sexual hypofunction and other features suggestive of hypogonadism seen in many of these patients.

Aged↗
PubMed1976

Luteinizing release hormone tests in impotent diabetic males.

Assessment of pituitary-gonadal function was made in impotent diabetic males using luteinizing hormone-release hormone tests. Serum testosterone, sex-hormone-binding globulin capacity, and basal and incremental gonadotrophin concentrations in the impotent diabetics were similar to those in control diabetics, suggesting a primary neurologic rather than an endocrine defect as the cause of the impotence.

Adult↗