Biomedical subjects
A D Woods
Publications and source records attributed to A D Woods.
Neuro-ophthalmic manifestations of AIDS.
As the incidence of human immunodeficiency virus (HIV) infection increases throughout the world, there becomes a greater probability that the primary care clinician will be confronted by AIDS-related complications. Neuro-ophthalmic problems, including optic neuropathies, motility disturbances, and visual field defects, are an important and common part of the AIDS spectrum. However diverse and challenging to the clinician, they may be the initial presentation of HIV infection. While opportunistic infections and neoplasms comprise the major source of neuro-ophthalmic problems, HIV itself may also be included. This paper is a review of the common causes of AIDS-related neuro-ophthalmic disorders and their clinical manifestations.
Morphometric analysis and fine structure of the vestibular epithelium of aged C57BL/6NNia mice.
The vestibular organs of young and very old C57BL/6NNia (B6) mice were compared by light and electron microscopy. Hair cell density decreased an average of 14% in the utricle, 19% in the saccule and posterior crista, 23% in the horizontal crista, and 24% in the anterior crista. Hair cell size remained the same throughout the mouse's life span as did the ratio of Type I to Type II hair cells. The most apparent sign of advanced age was dense inclusions found in sensory and supporting cells. Although small inclusions were present at five weeks, by 29 months, additional, larger forms appeared. An unusual melanin-like form was characteristic of old Type I hair cells. Synaptic morphology and synaptic bodies were well preserved even in very old B6 mice. Elongated bars were common in Type I hair cells and spheroid synaptic bodies were the most common form in Type II hair cells. Large clusters of synaptic bodies occurring in both young and old mice were seen only in Type I hair cells. Although the B6 strain suffers from genetically determined early cochlear degeneration, it does not experience early degeneration of the peripheral vestibular organs.
Persistence of synaptic bodies in saccular hair cells of senescent mice.
The morphology of the afferent synapse in type I (HCI) and type II (HCII) saccular hair cells was compared in juvenile and very old C57BL/6NNia mice. Normal membrane specializations and normal synaptic body (SB) form and organization were found to continue well beyond the expected life span. Although SB were found less frequently in HCI than in HCII, they were as readily found in old saccules as in juveniles. The elongated rod was the most common form in HCI and the spheroid was the most common in HCII. Large clusters of SB (greater than 5), found in both juvenile and old saccules, were unique to HCI. SB in HCII were generally found singly. A range of forms, including hollow and striated dense bodies, also occurred in both juvenile and very old saccules. Singular or clustered SB were found free in the cytoplasm as well as engaged at the membrane. No SB were seen at sites other than nerve terminal appositions. In rare instances a SB was observed engaged at a site that appeared to be opposite an efferent fiber.
Design and construction of an Australian sterile products plant.
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