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Biomedical subjects

A D Watson

Publications and source records attributed to A D Watson.

At least 127 records · Page 7Linked to original sources
PubMed1981

Comparison of several laboratory tests for quantifying azotaemia in dogs.

Fifty blood samples collected from 14 normal dogs and 11 dogs with renal disease and azotaemia were assayed in various ways for urea and creatinine. Urea concentrations measured by Azostix, Urastrat and Unitest correlated well with a reference urea assay method, and there was good correlation between creatinine concentrations determined by Unitest and a reference method. The performance of the four simpler laboratory procedures examined was considered satisfactory for clinical purposes.

Animals↗
PubMed1981

Postprandial changes in plasma urea and creatinine concentrations in dogs.

Changes in plasma urea and creatinine concentrations were compared in 6 dogs fed 3 meals (cooked meat, raw meat, and a soft-moist preparation) in a crossover fashion. Each meal produced changes in urea and creatinine values. Although increased urea values were seen after all meals, the effects on creatinine were varied; concentrations increased after feeding cooked meat, but decreased after consumption of raw meat or soft-moist food. Although the creatinine changes were less pronounced, the variable effect of diet complicates the interpretation of plasma creatinine concentration in evaluating renal function.

Animal Feed↗
PubMed1980

Phenylbutazone-induced blood dyscrasias suspected in three dogs.

Blood dyscrasias developed after drug therapy in three dogs. Two died, one with pancytopenic marrow failure and the other with non-regenerative anaemia and thrombocytopenia. The third dog developed pancytopenia but recovered. An adverse reaction to phenylbutazone was suspected as the cause in each case, although two of the dogs had also received other drugs which sometimes cause blood dyscrasias in humans.

Anemia↗
PubMed1980

Giardiosis and colitis in a dog.

An 18-month-old Cavalier King Charles Spaniel with recurrent diarrhoea for 2 months had signs suggesting dysfunction of small and large bowel. No helminth ova, protozoa or fat were found on faecal examination. Proctoscopy, barium enema examination and colonic biopsy revealed mucosal colitis. Biopsied small intestine was histologically normal but Giardia trophozoites were numerous in fluid aspirated from the duodenum. Absorption of d-xylose was normal. Giardiosis and idiopathic colitis were diagnosed. Clinical signs abated after 2 courses of metronidazole administration.

Animals↗
PubMed1980

Canine laryngeal oncocytomas.

Solitary, protruding tumors were found in the wall of the larynx in three adult dogs with clinical upper respiratory obstruction. They were composed of cells with abundant granular acidophilic cytoplasm, the granularity caused by an unusually large number of mitochondria. The lesions were considered to be neoplasms arising from oncocytes as described in man. Oncocytomas have not been reported previously in domestic animals.

Adenoma↗
PubMed1980

Further observations on chloramphenicol toxicosis in cats.

After a base-line period (14 days), five cats were orally given 50 mg of chloramphenicol every 12 hours for 21 days. Clinical signs of toxicosis were CNS depression, reduced intake of food and water, and weight loss. Changes in peripheral blood included lower platelet counts after treatment for 1 week and fewer neutrophils after treatment for 3 weeks; one cat developed lymphocytopenia after 1 week and neutropenia after 2 weeks. Changes in bone marrow at the end of treatment comprised vacuolation of early myeloid cells and lymphocytes, and reduced myeloid maturation ratio, and some cats also had reduced marrow cellularity, or increased myeloid:erythroid ratio, or both of these.

Animals↗
PubMed1980

Large intestinal biopsies from normal dogs.

Proctoscopic examination and rectal and colonic biopsies were performed in 10 clinically normal dogs. There was some variation between individuals in the gross and light microscopic appearance of normal canine large intestine but the findings were distinct from those in disease.

Animals↗
PubMed1979

A comparative study on the innervation and the vascularization of the bulbus arteriosus in teleost fish.

The structure of the bulbus arteriosus of a wide range of teleost fish is described with particular reference to the vascularization and innervation. The adventitia of the organ consists of blood vessels and large nerve bundles in a collagen matrix. The nerve bundles contain monoamines, and fluorescence studies show small terminal bundles penetrating the muscular media; this is confirmed by electron microscopy. The media consists of an extensive elastic tissue matrix with a spiral arrangement of smooth muscle cells joined end to end by desmosomes and presumed electronic junctions. The muscles cells are innervated only at the adventitia/media boundary and the significance of this innervation is discussed. It is proposed that there is a correlation between the degree of vascularization and innervation and the activity of a particular species of fish.

Animals↗