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Biomedical subjects

A D Thomson

Publications and source records attributed to A D Thomson.

At least 55 records · Page 3Linked to original sources
PubMed1983

Plasma vitamin E status in chronic alcoholic patients.

Plasma vitamin E (alpha-tocopherol) concentrations were estimated by high performance liquid chromatography (HPLC) in 50 consecutively admitted chronic alcoholics (M = 44;F = 6;mean age +/- S.D. = 42.94 +/- 10.97;age range = 28-70 years) on admission and in 25 of them it was repeated during abstinence (6th day) while undergoing conventional detoxification therapy with polyvitamins (except vitamin E) and hypno-sedative drugs. Thirty percent of the patients were found to be deficient on admission and while on routine hospital diet during therapy, 20% of the patients were still deficient. It is, therefore, suggested that chronic alcoholics should be treated routinely with vitamin E along with other polyvitamins during detoxification in alcoholic units.

Adult↗
PubMed1983

Vitamin A utilization status in chronic alcoholic patients.

The utilization status of vitamin A (retinol) (treated with oral retinol - 2500 I.U. daily (=250 micrograms) x 5 days - "OROVITE -7", Bencard, England) in 25 patients (M = 23, F = 2; mean age +/- S.D. = 43.88 +/- 12.67; range = 28-70 years), 3 out of 25 patients (12%) were found to be deficient in the vitamin and during treatment further improvement of the blood levels of the vitamin was observed in all except one elderly male patient (age 61 years) and the mean levels on admission (661.04 micrograms/l) was also slightly improved after treatment (662.84 micrograms/l). Night blindness, alcoholic liver disease and hypogonadism are commonly seen in chronic alcoholic patients. Falling plasma levels of the vitamin indicate exhaustion of its hepatic storage. It is therefore suggested that chronic alcoholics should be given vitamin A supplementation along with other polyvitamins during conventional detoxification therapy for ethanol withdrawal syndrome in order to prevent dangerous manifestations of hypovitaminosis A, such as night blindness, cancer, hypogonadism and alcoholic liver disease.

Adult↗
PubMed1982

Plasma urea and creatinine status in chronic alcoholics.

Plasma urea and creatinine concentrations were estimated by Auto-Analyzer in 128 chronic alcoholics (103 males, 25 females; mean age +/- SD = 42.73 +/- 6.53; age range 20-60 years). Plasma levels of both urea (mean +/- SD = 3.46 +/- 1.31; normal range 2.0-6.5 mmol/l) and creatinine (mean +/- SD = 87.86 +/- 15.45; normal range 60-120 mumol/l) were found to be within normal limits. It is concluded from our observations that chronic ethanol ingestion per se is not nephrotoxic. The kidney seems to be the only vital organ generally spared in chronic alcoholics without advanced alcoholic liver disease or hepato-renal syndrome.

Adult↗
PubMed1982

Blood vitamin status (B1, B2, B6, folic acid and B12) in patients with alcoholic liver disease.

Blood vitamin status (B1, B2, B6, folic acid and B12) was assessed in 41 patients (M = 39; F = 2) with alcoholic liver disease. Biochemical evidence of thiamine deficiency was observed in all groups of patients. Deficiency of riboflavin was detected in patients with histologically normal liver but not in other groups. All the groups were found to be deficient in pyridoxal-5-phosphate--the active form of vitamin B6 (pyridoxine). Serum folate was decreased in all groups except in those with alcoholic hepatitis: red cell folate was, of course within normal limits in all the groups. Vitamin B12 levels were within normal limits in all groups except the cirrhotic one where it was raised. Clinico-biochemical implications of the findings are discussed. Biochemical changes in blood vitamin status may precede clinical manifestations of a disease process and may have prognostic value.

Adult↗
PubMed1981

Thyroid status in chronic alcoholics.

Serum thyroxine (T4), triiodothyronine (T3) and thyrotrophin (TSH) were measured by radioimmunoassay in 39 chronic alcoholics on admission. Two patients had a reduced circulating serum T4 and eight showed a low serum T3 level but basal TSH was not raised in any of the 39 patients. Interestingly, low T4 and T3 levels returned to normal after abstinence and high protein and vitamin supplemented diet for one week. It is clear from our observations that a normo- or hypo- rather than a hypermetabolic or hyperthyroid state is more common in drinking chronic alcoholics. Ethanol-induced "low T3 syndrome" has also been described and a mechanism of its pathogenesis is suggested.

Adult↗
PubMed1981

Vitamin utilization status in chronic alcoholics.

Chronic alcoholics are very often found to be deficient in vitamins. The object of the study was to assess the vitamin utilization of twelve drinking chronic alcoholics after intravenous therapy with polyvitamins. The following enzyme activation tests in red blood cells were used: a) Erythrocyte transketolase (ETK) activity for B1; b) Glutathione reductase (EGR) activity for B2; c) Pyridoxal-5-phosphate (PALP)--the active metabolite of vitamin B6 (pyridoxine) was directly estimated in red blood cells. Seven out of 12 patients were deficient in B1 before treatment; 6/12 in B2 and 11/12 in PALP. But all returned to normal after treatment; mean plus or minus SD of ETK activation co-efficient improved from the pre-treatment level of 1.174 plus or minus 0.135 to 1.001 plus or minus 0.009 (adequate less than or equal to 1.15); mean plus or minus SD of EGR activation coefficient from 1.265 plus or minus 0.333 to 1.015 plus or minus 0.072 (adequate less than or equal to 1.19) and PALP rose from 6.78 plus or minus 6.47 to 60.68 plus or minus 85.85 after treatment (adequate = vv10-20 ng/ml). These observations indicate the need for relevant vitamin supplementation in chronic alcoholics and also support the inclusion of intravenous polyvitamins in conventional detoxification regime for chronic alcoholics.

Adult↗