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Biomedical subjects

A D Sadovnick

Publications and source records attributed to A D Sadovnick.

131 records · Page 8Linked to original sources
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A cost-benefit analysis of a population screening programme for neural tube defects.

Population screening for neural tube defects is possible by measuring maternal serum alphafetoprotein levels with appropriate follow-up as required. British Columbia has approximately 39 000 births annually and the incidence of neural tube defects is 1.55 per 1000 births (0.94 per 1000 livebirths). Results from a cost-benefit analysis suggest that the outlined screening programme would be cost-beneficial for British Columbia. Other important factors essential to consider before instituting a population screening programme are discussed.

British Columbia↗
PubMedDate not supplied

Temporal changes in the utilization of amniocentesis for prenatal diagnosis by women of advanced maternal age, 1976-1983.

Utilization of amniocentesis for prenatal diagnosis because of the indication of advanced maternal age (greater than or equal to 35 years at delivery) was examined in the population of B.C. over an 8-year period (1976-1983). As of 1983, approximately one out of three eligible women (greater than or equal to 35 years at delivery) is having the test. In the older group (greater than or equal to 38 years at delivery) approximately one out of two eligible women is having the test. The data do not indicate that the proportion of eligible women having amniocentesis has reached a plateau; utilization is continuing to increase. It appears that prenatal diagnosis is an ethically acceptable alternative for a large proportion of the population.

Adult↗
PubMedDate not supplied

Underlying causes of death in Down syndrome: accuracy of British Columbia death certificate data.

British Columbia (B.C.) provides an excellent opportunity to study the accuracy of assigning Underlying Cause of Death (UCOD) in Down syndrome. The study was designed to evaluate the effect of inappropriate interpretation of guidelines for completing the death certificate. All B.C. livebirths identified as having Down syndrome during the period 1952-1981 were collected from the records of the B.C. Health Surveillance Registry. Of the 1,337 affected individuals identified, 324 (24.2%) had died. The death certificates on these individuals were reviewed to assess from the information on the death certificate whether the underlying cause of death appeared to have been assigned in accordance to World Health Organization coding guidelines. The UCOD appeared to be assigned appropriately for 165/315 cases (52.4%). It is possible that in the situation where an easily recognizable condition such as Down syndrome is present, the need to identify the actual UCOD may be viewed as less urgent compared with cases where an apparently "normal" individual dies.

British Columbia↗