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Biomedical subjects

A D Mercando

Publications and source records attributed to A D Mercando.

At least 19 recordsLinked to original sources
PubMed2000

Prevalence of coronary artery disease, complex ventricular arrhythmias, and silent myocardial ischemia and incidence of new coronary events in older persons with chronic renal insufficiency and with normal renal function.

In a prospective study of 98 persons > or = 65 years of age with chronic renal insufficiency (serum creatinine > 3.0 mg/dl) for > 1 year and 98 age- and sex-matched persons with normal renal function (serum creatinine < or = 1.2 mg/dl), new coronary events developed at 23-month follow-up in 69 persons (70%) with chronic renal insufficiency and at 48-month follow-up in 24 persons (24%) with normal renal function (p < 0.0001). Significant independent risk factors for new coronary events were age (risk ratio 1.1), prior coronary artery disease (risk ratio 3.5), complex ventricular arrhythmias diagnosed by 24-hour ambulatory electrocardiography (risk ratio 2.5), silent myocardial ischemia diagnosed by 24-hour ambulatory electrocardiography (risk ratio 1.9), and chronic renal insufficiency (risk ratio 3.4).

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PubMed1998

Effect of benazepril on complex ventricular arrhythmias in older patients with congestive heart failure, prior myocardial infarction, and normal left ventricular ejection fraction.

Sixty patients, mean age 82 +/- 8 years, with congestive heart failure, prior myocardial infarction, normal left ventricular ejection fraction, and > or = 30 ventricular premature complexes per hour detected by 24-hour ambulatory electrocardiograms, and who were treated with diuretics, were randomized to treatment with benazepril 20 to 40 mg/day (30 patients) or to no benazepril (30 patients). At a median of 6 months after treatment, follow-up 24-hour ambulatory electrocardiograms showed that compared with no benazepril, benazepril caused no significant reduction in the number of ventricular premature complexes per hour or in the number of runs of ventricular tachycardia per 24 hours.

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PubMed1997

Appointment scheduling on computer.

The program is well-written, intuitive, and easy to use once initial data, such as the available appointment slots, has been entered. While the effort may not seem worthwhile initially, the ability to access an office appointment book from several locations simultaneously and the reporting capabilities of the software make MEDSched a useful addition to any busy office practice or clinic. Please send your comments and suggestions to me at adm4@columbia.edu.

Appointments and Schedules↗
PubMed1996

Association of average heart rate on 24-hour ambulatory electrocardiograms with incidence of new coronary events at 48-month follow-up in 1,311 patients (mean age 81 years) with heart disease and sinus rhythm.

A prospective study performed in 1,311 men and women, mean age 81 years, with heart disease and sinus rhythm showed at 48-month follow-up that male sex, increasing age, and average 24-hour heart rate measured from 24-hour ambulatory electrocardiograms were independent risk factors for new coronary events. There was a 1.14 times higher chance of developing new coronary events for an increment of 5 beats/min of heart rate after controlling the confounding effect of other risk factors.

Age Distribution↗
PubMed1996

Correlation of paroxysmal supraventricular tachycardia, atrial fibrillation, and sinus rhythm with incidences of new thromboembolic stroke in 1476 old-old patients.

The relationship between supraventricular tachycardia and the incidence of thromboembolic stroke has not been previously reported. We investigated in a prospective study the incidence of new thromboembolic stroke in 1476 patients, mean age 81 years, with atrial fibrillation, paroxysmal supraventricular tachycardia, or sinus rhythm detected by 24-hour ambulatory electrocardiograms. New thromboembolic stroke developed at 31-month follow-up in 87 of 201 patients (43%) with atrial fibrillation, at 43-month follow-up in 84 of 493 patients (17%) with paroxysmal supraventricular tachycardia, and at 45-month follow-up in 143 of 782 patients (18%) with sinus rhythm (p < 0.0001 comparing atrial fibrillation with paroxysmal supraventricular tachycardia or sinus rhythm). Kaplan-Meier survival curves showed a higher significance of thromboembolic stroke in patients with atrial fibrillation, compared to patients with paroxysmal supraventricular tachycardia or sinus rhythm (log-rank: p < 0.0001). Multivariate Cox regression model showed that independent significant predictors of thromboembolic stroke were: a) atrial fibrillation (relative risk = 3.31); b) prior thromboembolic stroke (relative risk = 2.85); c) sex (relative risk for women = 0.75); and d) age (relative risk = 1.02). These data show that atrial fibrillation is an independent predictor of thromboembolic stroke in elderly patients, and that paroxysmal supraventricular tachycardia is not associated with thromboembolic stroke.

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PubMed1996

A relational database for storing clinical information.

In medicine, we are constantly acquiring, recording, and analyzing data. Database programs give us a powerful tool to save and report our data. While spreadsheets and even word processing software can store simple datasets, the complexity of data storage needs in medicine often requires the use of a database program. Using most database software was difficult task for the casual user until recently, new, powerful programs were introduced by several developers. Microsoft Access, which is licensed for use with the purchase of many new computers, is an extremely powerful and relatively easy to use program written for the Windows operating systems. With this program, even novices to database programming can learn to construct useful database management systems.

Database Management Systems↗
PubMed1995

Signal-averaged electrocardiography and ventricular tachycardia as predictors of mortality after acute myocardial infarction in elderly patients.

Signal-averaged electrocardiography and 24-hour ambulatory electrocardiographic monitoring were performed in 121 elderly patients > 6 months after acute myocardial infarction. All patients had asymptomatic complex ventricular arrhythmias and a left ventricular ejection fraction > or = 40%. Rates of sudden, cardiac, and total death were compared between groups with and without nonsustained ventricular tachycardia and between normal and abnormal signal-averaged electrocardiographic studies. The prevalence of an abnormal signal-averaged electrocardiographic study was 36%. Thirty-seven percent of the patients had nonsustained ventricular tachycardia, and the remaining patients had complex ventricular arrhythmias other than ventricular tachycardia. There were 27 sudden and 48 total cardiac deaths, and 66 deaths from all causes during a mean follow-up period of 30 months. Kaplan-Meier survival analysis showed a lower rate of sudden and cardiac death in the group without nonsustained ventricular tachycardia. Although there was a trend toward a lower rate of sudden death in patients with a normal signal-averaged electrocardiogram, there was no statistical difference in the rates of sudden, total cardiac, or total death between patients with normal or abnormal studies. The negative predictive value of having neither an abnormal signal-averaged electrocardiogram nor nonsustained ventricular tachycardia was 94% for sudden death. In elderly patients with complex ventricular arrhythmias and ejection fraction > or = 40% at least 6 months after an acute myocardial infarction, presence of nonsustained ventricular tachycardia predicted a higher rate of sudden and cardiac death. Signal-averaged electrocardiography alone was not predictive.

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PubMed1995

Usefulness of an abnormal signal-averaged electrocardiogram for predicting cardiac death in elderly persons without heart disease.

We found an abnormal signal-averaged ECG in 7 of 51 elderly patients (14%) (mean age 83 years) without clinical evidence of heart disease, and in 1 of 25 volunteers (4%) (mean age 31 years range [17 to 47]) without clinical evidence of heart disease. The data from our prospective study indicate that at 43-month mean follow-up, elderly patients with an abnormal signal-averaged ECG but no clinical evidence of heart disease do not have an increased incidence of sudden cardiac death, total cardiac death, or total death.

Age Factors↗
PubMed1995

Association of silent myocardial ischemia with new atherothrombotic brain infarction in older patients with extracranial internal or common carotid arterial disease with and without previous atherothrombotic brain infarction.

OBJECTIVE: To correlate silent myocardial ischemia with the incidence of new atherothrombotic brain infarction (ABI) in older patients with 40 to 100% extracranial carotid arterial disease (ECAD) with and without prior ABI. DESIGN: In a prospective study of 208 older patients with 40 to 100% ECAD diagnosed by carotid duplex ultrasonography, 24-hour ambulatory electrocardiograms were obtained to detect silent myocardial ischemia. At 42-month mean follow-up, silent myocardial ischemia was correlated with the incidence of new ABI in patients with and without prior ABI. SETTING: A large long-term health care facility where 208 older patients with 40 to 100% ECAD and technically adequate 24-hour ambulatory electrocardiograms for detecting silent myocardial ischemia were studied. PATIENTS: The 208 patients included 68 men and 140 women, mean age 81 +/- 8 years (range 60 to 100). One-hundred three (50%) of the patients had prior ABI. MEASUREMENTS AND MAIN RESULTS: Sixty-nine (33%) of the 208 patients had silent myocardial ischemia. Mean follow-up was 42 +/- 25 months (range 3 to 101 months). At follow-up, the incidence of new ABI was 64% in patients with prior ABI and 32% in patients with no prior ABI (P < .0001). At follow-up, the incidence of new ABI was 65% in patients with silent ischemia and 40% in patients with no silent ischemia (P = .0005). The multivariate Cox regression model showed that patients with prior ABI have a 2.5 times higher chance of developing new ABI than those without prior ABI after controlling other prognostic variables. Patients with silent ischemia have a 2.1 times higher probability of developing new ABI than those without silent ischemia after controlling other prognostic variables. CONCLUSIONS: Prior ABI and silent ischemia are independent risk factors for the development of new ABI in patients with 40 to 100% ECAD. This probably reflects that silent ischemia is a marker for more advanced or more significant atherosclerotic disease rather than a causal factor for ABI.

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