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Biomedical subjects

A D McLachlan

Publications and source records attributed to A D McLachlan.

At least 19 recordsLinked to original sources
PubMed1979

Four-fold structural repeat in the acid proteases.

The observation that the acid proteases contain two structurally equivalent lobes related by a dyad through the active centre has been extended to show that in endothiapepsin each lobe contains two similar halves related by a further local dyad. In lobe 1 22 pairs of alpha-carbons are equivalent with a root mean square deviation of 1.92 A. In lobe 2 17 pairs match within 2.31 A. Convergent evolution or gene quadruplication may have occurred.

Amino Acid Sequence↗
PubMed1978

Serum albumin domain secondary structure prediction.

A new method has been used to predict probability profiles for helix, beta-sheet and bend structures along the entire sequence and derive an averaged profile for the three homologous domains. The results are correlated with the disulphide bridge pattern, the distribution of hydrophobic sites and points where albumin is cleaved by enzymes.

Amino Acid Sequence↗