Search PubMed⌕ Search

Biomedical subjects

A D Marks

Publications and source records attributed to A D Marks.

34 records · Page 2Linked to original sources
PubMed1978

The pressor response to angiotensin II in patients with low renin essential hypertension.

The etiology of low renin essential hypertension (LREH) has not been established with certainty, but mineralocorticoid excess has been implicated frequently in its pathogenesis. The finding of several investigators of a normal exchangeable sodium space and extracellular fluid volume, however, does not support this hypothesis. To evaluate the possible role of sodium and water retention in LREH, the pressor response to infused angiotensin II (A II) was determined and compared to that of normal subjects and that of subjects with normal renin essential hypertension (NREH). This approach was based on the known suprasensitivity of vascular receptors to A II in situations in which sodium and water compartments are expanded as they are, for example, in proven hypermineralocorticoid states such as primary aldosteronism. In this study, we found that subjects with LREH demonstrated no increased pressor response to graded doses of A II; this suggests that LREH is not primarily mediated by sodium and water retention.

Adult↗
PubMed1978

Propranolol for the preoperative preparation of patients with thyrotoxicosis.

Thirty patients with hyperthyroidism were were prepared for subtotal thyroidectomy with propranolol. Rapid control of thyrotoxic symptoms occurred in all, and there were no undesirable drug reactions. There were no instances of post-operative thyroid storm. The drug was as effective and safe in four patients who were pregnant as it was in the other 26 patients discussed. We consider propranolol to be the drug of choice in the preoperative preparation of most patients with thyrotoxicosis.

Adolescent↗
PubMed1975

Low-renin hypertension. Occurrence in vascular complications.

Two hundred one patients with essential hypertension, who had studies of their renin-aldosterone system performed between April 1967 and December 1972, were surveyed for myocardial infraction or cerebrovascular accident. Of the patients, 42% had low plasma renin activity. Myocardial infractions or cerebrovascular accidents were documented in 15% of those with low plasms renin activity and in 5% of those with normal plasma renin activity. When adjustments were made for differences in afe and blood pressure , a protective effect in low-renin hypertension was evident. When black patients were considered separately,there was no difference in diastolic blood pressure; however, vascular complications were not less frequent in low-renin hypertensives. The results suggest that low plasma renin activity does not protect against the development of vascular complications in essential hypertension.

Black People↗
PubMed1975

The presence of histone H1degree in human tissues.

Histone Hidegree was found to be present in a number of human tissues. It constituted 50% of the total 5% perchloric acid-soluble histone in human breast, 35%in thyroid, 12 to 18% in adrenal, and 7% in parathyroid tissues. The quantities of histone Hldegree in these human tissues were large compared with the amounts found in rat liver (8%), calf thymus (0%), and HeLa cells (0%). Although the quantity of histone Hldegree was found to vary from one type of tissue to another, it was essentially constant in normal, hyperplastic, and neoplastic human thyroid tissues.

Adrenal Glands↗
PubMed1971

Myoglobinuria.

Explore the source record for details and available documents.

Biopsy↗
PubMedDate not supplied

Serum immunoglobulins in hypertension.

We measured serum immunoglobulins in 52 persons whose blood pressure was higher than 140/90 mm Hg, and 52 normotensive controls matched for age, sex and race. All were selected from a population of actively employed persons undergoing a routine health evaluation. Contrary to previous reports, the hypertensive subjects did not have higher levels of IgG or IgA than the controls. Sixteen hypertensive subjects with mean blood pressure higher than 115 mm Hg did not have elevated IgG or IgA levels when analyzed separately. Serum IgM was significantly lower in the 52 hypertensive subjects (125 +/- 67 mg/dl vs 171 +/- 85 mg/dl, p less than 0.01). Our subjects failed to show the increase in immunoglobulins reported by others. The most likely reasons for this is the mildness of their blood pressure elevation, although the absence of immunoglobulin elevation in the small number with more marked hypertension does not support this explanation.

Adult↗