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Biomedical subjects

A D Makatsariia

Publications and source records attributed to A D Makatsariia.

At least 19 recordsLinked to original sources
PubMed2004

[Endotheliopathy in the genesis of fetus loss syndrome as observed in pregnant women with chronic viral infection].

The main reasons of fetus loss as observed in pregnant women with chronic viral infection are discussed in the paper. The role of the immune system and different mechanisms of endothelial lesions inherent in the genesis of the discussed phenomenon are analyzed. An approach to management of pregnancy in patients with viral infections targeted at the prevention of pregnancy complications is suggested on the basis of the analysis and independent authors' observations.

Abortion, Spontaneous↗
PubMed2001

[Thrombophilia and fetal loss syndrome].

Pathological states associated with congenital and acquired hemostasis defects remain a pressing problem of practical obstetrics. Thrombophilia is responsible for 30-50% of habitual miscarriages, severe gestosis, detachment of normally attached placenta, preterm delivery, etc. Therefore, today correct therapeutic strategy determines the prevention of reproductive loss caused by thrombophilic state. A complex of studies aimed at drug prevention of miscarriages has been performed at Department of Obstetrics and Gynecology, Medical Prophylaxis Faculty of I. M. Setchenov Moscow Medical Academy. Seventy-two pregnant women without extragenital diseases with verified congenital or acquired hemophilia and fetal loss syndrome were observed. Various therapeutic protocols with low-molecular-weight heparin were used. Positive clinical results were attained: no relapses of thrombosis and fetal loss occurred in the majority of cases, though the incidence of preterm labor and placental insufficiency remained high.

Female↗
PubMed1993

[The hemostatic system in pregnant women and puerperae with the tetralogy of Fallot].

The hemostasis system was studied in 31 pregnant women with Fallot's tetralogy, aged 18 to 32. In women with a history of radical correction of this condition a subcompensated form of the DIC syndrome was detected, manifesting as chronometric and structural hypercoagulation and platelet hyperaggregation. In patients with the cyanotic form of Fallot's tetralogy hypocoagulation thrombophilia was revealed, that was due to deficiency of contact factors (Hageman factor, highly molecular kininogene) and that was responsible for thrombohemorrhagic complications in these patients. Replacement therapy is recommended for such cases in labor and controlled anti-thrombotic therapy in the postpartum period.

Adolescent↗
PubMed1991

[The differential diagnosis and principles of the prevention of thromboembolic complications in pregnant women with artificial heart valves].

Clinical and hemostasiologic examinations of 28 pregnant women with artificial heart valves helped detect various mechanisms of thrombophilia development. Marked platelet hyperactivity was detected in all the examinees, regarded as the principal pathogenetic risk factor of arterial thromboembolism. A wave-like course of the DIC syndrome with hypercoagulation replaced by hypocoagulation was recorded in 79.6% of pregnant women with artificial heart valves. Differentiated controlled antithrombotic therapy, administered with due consideration for the cause of thrombophilia, helped prevent thromboembolic complications.

Adult↗
PubMed1990

[Differential prevention of recurrence of thrombosis during pregnancy].

Pregnancy in patients with a history of thrombotic complications puts them at a great risk of thrombosis and obstetric complications (hypoxia, intrauterine hypotrophy, bleedings). Functional strain of the hemostasis system occurs at the onset of pregnancy in women with a history of thrombotic complications without clinical symptoms of thrombosis. The incidence of disseminated intravascular coagulation with activation of both pro-coagulation and platelet-mediated hemostasis is 33% and that with activation of only platelet-mediated hemostasis is 64%. Differential use of antithrombotic drugs prevents thrombosis recurrence in 98% of patients.

Adult↗
PubMed1989

[Clinical significance of disorders of hemostasis in children with chronic pneumonia and mucoviscidosis].

The results of the clinical observations over 127 patients with mucoviscidosis and chronic (primary and secondary) pneumonia are presented. The children were aged from 1 to 15 years. Study of the plasma and platelet links of hemostasis permitted one to reveal considerable disorders seen during exacerbation in all the groups. The intensity of the disorders correlated well with the gravity of the patient's condition and with the bronchopulmonary process spreading as well as with the presence of complications on the part of the cardiovascular system (cor pulmonale) and the hepatobiliary system (liver cirrhosis). The chronic form of the disseminated intravascular coagulation (DIC) syndrome was diagnosed in 50 percent of the patients with mucoviscidosis, in 1/3 of the patients with secondary and in 18 percent of the patients with primary chronic pneumonia. The subacute form of the DIC syndrome was diagnosed in 15 percent of the patients with mucoviscidosis and in 4.5 percent of the patients with secondary chronic pneumonia. The multimodality treatment without heparin made it possible to correct the hemostatic disturbances in the majority of the patients under observation. In some children with mucoviscidosis and secondary chronic pneumonia, the use of heparin in the form of intravenous injections or ultrasonic inhalations permitted making such a correction more rapidly and more completely.

Adolescent↗
PubMed1989

[Heparin therapy of pregnant women with placental insufficiency].

In the presence of low-dosage administrations of heparin the system of hemostasis was studied in 50 pregnant females with placental failure and the chronic DIC syndrome. The efficacy of the treatment conducted was assessed with regard to the revealed levels of coagulation natural inhibitors, the products of fibrinogen-fibrin degradation, the degree of thrombocytic functional recovery and stabilization of the chronometric values of coagulation. The latter parameters considered together with the levels of heparinemia served as the criteria for the safety of the drug dosages employed.

Adult↗