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Biomedical subjects

A D Harrower

Publications and source records attributed to A D Harrower.

At least 55 records · Page 3Linked to original sources
PubMed1977

Growth hormone, insulin, and prolactin secretion in anorexia nervosa and obesity during bromocriptine treatment.

We studied secretion of growth hormone (GH), insulin, and prolactin in eight women with anorexia nervosa and nine women with refractory obesity before and during treatment with bromocriptine, 10 mg/day. In the anorexic patients the raised plasma GH concentrations occurring during an oral glucose tolerance test fell significantly while on bromocriptine treatment, but there was no change in plasma insulin or blood glucose concentrations. In the obese patients, however, plasma GH concentrations remained low during the oral glucose tolerance test, and were not modified by bromocriptine. Blood glucose and plasma insulin concentrations were also unchanged. Plasma GH and plasma 11-hydroxycorticosteroid responses to insulin-induced hypoglycaemia were unaffected. Serum prolactin concentrations which were raised in five anorexic patients and marginally raised in two obese subjects, fell significantly in both groups during treatment. We observed no consistent weight changes in either groups.

Adolescent↗
PubMed1977

Thyroxine and triiodothyronine levels in hyperthyroid patients during treatment with propranolol.

Serum triiodothyronine (T3) and thyroxine (T4) levels were measured in twelve hyperthyroid patients before and after treatment with propranolol, 40 mg four times daily, for 2 weeks. There was a significant fall in serum T3 and a significant rise in serum T4 concentrations in the group as a whole and it was concluded that the clinical effectiveness of propranolol in hyperthyroidism may be mediated in part by its action on the peripheral metabolism of thyroid hormones. Propranolol treatment should be withdrawn gradually as removal of the suppressive action of the drug on thyroid hormone metabolism is potentially hazardous, particularly in patients with ischaemic heart disease.

Adult↗
PubMed1977

Effect of propranolol on glucose tolerance in hyperthyroidism.

Glucose tolerance tests were performed on six hyperthyroid patients in the morning and afternoon before, and at the end of treatment with propranolol for 2 weeks. All six subjects showed normal glucose tolerance with a normal diurnal rhythm before treatment and this remained normal in five during treatment with propranolol, while one patient developed abnormal glucose tolerance and the diurnal variation was abolished. No change in insulin levels was noted in any of the patients either before or during treatment. Propranolol may cause deterioration in glucose tolerance in some subjects with hyperthyroidism and this possibility should not be overlooked.

Adult↗
PubMed1977

Failure of luteinizing hormone-releasing hormone and insulin to further augment thyrotrophin release in primary hypothyroidism.

The effect of luteinizing hormone-releasing hormone (LH-RH) and insulin-induced hypoglycaemia on the release of thyrotrophin (TSH) was studied in five patients with primary hypothyroidism. All five patients had elevated TSH levels with an exaggerated rise in response to thyrotrophin-releasing hormone (TRH). No rise over control values was found after LH-RH or insulin indicating that despite the augmentation of TSH release in primary hypothyroidism there is no alteration of the specificity of the thyrotroph response.

Adult↗
PubMed1977

The diabetic foot.

Explore the source record for details and available documents.

Diabetes Complications↗
PubMed1976

Experience of coronary care in diabetes.

During 1968-1973, 94 patients with diabetes were admitted to a coronary care unit (CCU) on 99 occasions with proved myocardial infarction. Altogether 24 of them (25-5%) died, giving an overall mortality at the time of discharge of 24% for the total admissions. This was just significantly higher than the 19% mortality recorded among non-diabetics treated in the same period but was much lower than that among diabetics treated for myocardial infarction before the advent of CCUs. No definite correlation was found between the type of anti-diabetic treatment and either mortality or the incidence of primary ventricular fibrillation. Patients with "poor" control of the diabetes before admission showed a significantly higher mortality than those with "good" control, but there was no significant difference in mortality between those with previous good control and non-diabetics.

Aged↗
PubMed1976

Diabetic retinopathy with normal glucose tolerance.

A case is reported of a patient with typical diabetic retinopathy, but with normal glucose tolerance. Previously reported cases are reviewed and it is concluded that in such patients the diabetes is probably latent, the retinopathy being discovered during a period of natural or induced remission.

Diabetes Mellitus↗
PubMed1975

Comparison of injection techniques for soluble and protamine zinc insulins in diabetes mellitus.

Soluble and protamine zinc insulins were given to six insulin-dependent diabetic patients using three different techniques of administration to determine whether the recommended single injection of the insulins, from separate syringes with the needle redirected, compared more closely with separate injections or with a single injection from the same syringe. It was shown that the mixture of the two insulins in the same syringe resulted in both a significant loss of the initial rapid effect of soluble insulin and an increased protamine zinc action with the risk of late night-time hypoglycaemia. A single injection of the insulins, using separate syringes and redirecting needle, gave at least as satisfactory control of the 24-hour blood glucose profile as when they were given by separate injections.

Adolescent↗
PubMedDate not supplied

The effect of the acute administration of tolbutamide on left ventricular function in insulin-dependent diabetics.

Despite better control of diabetic patients with morbidity and mortality from heart disease is significantly higher than in non-diabetics. While this may be a result of premature atherosclerosis or primary diabetic cardiopathy, the possibility of oral hypoglycemic agents have adverse cardiac effects must be considered. Using nuclear angiography the effect of the acute administration of 1 g tolbutamide on left ventricular ejection fraction (EF) in a group of 10 Type-1 diabetics was investigated. There was no difference in the response of the EF when compared to the response in 10 diabetic controls given i.v. saline. While i.v. tolbutamide may have adverse cardiac effects when administered to animals or in vitro this does not necessarily apply to human diabetics.

Adult↗