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Biomedical subjects

A D Dayan

Publications and source records attributed to A D Dayan.

At least 91 records · Page 5Linked to original sources
PubMed1972

Immune complexes and visceral deposits of measles antigens in subacute sclerosing panencephalitis.

Immunofluorescence has been used to study visceral organs from a case of subacute sclerosing panencephalitis. Immune complexes were shown as granular deposits of IgG, complement, and measles antigens in renal glomeruli. Measles antigens were detected in the spleen, liver, and lymph nodes from many parts of the body.Immune-complex formation may be important in the aetiology of this disease and perhaps in causing some of its tissue damage. The rarity of subacute sclerosing panencephalitis may be due to an unusual pattern of immunological reactivity required in a patient before a measles infection can produce a subacute encephalitis.

Adult↗
PubMed1972

Peripheral neuropathy in chronic liver disease: clinical, electrodiagnostic, and nerve biopsy findings.

In a prospective study of 70 unselected patients with chronic liver disease, clinical signs of a peripheral neuropathy were observed in 13 patients. Abnormal nerve conduction was demonstrated in nine of these and in one further patient who had no abnormal neurological signs. The occurrence of a neuropathy (in patients with cryptogenic cirrhosis, haemochromatosis, active chronic hepatitis as well as in alcoholic cirrhosis) could not be related to liver function, although it was associated with higher IgA and IgM values. Clinical diabetes was present in six of the 14 patients with neuropathy but there was no relation in the non-diabetic patients between neuropathy and minor impairment of carbohydrate tolerance. Those with neuropathy had a significantly higher incidence of oesophageal varices and there was also a relationship to a history of previous encephalopathy. Sural nerve biopsy was carried out on 14 patients, eight of whom had clinical or electrodiagnostic evidence of neuropathy. Single nerve fibres were examined by teasing and in all nerves histological evidence was found of an indolent process which had damaged whole Schwann cells and which resulted in demyelination and remyelination. Diabetic angiopathy was not seen and axonal degeneration, which was never severe, was found in all disease groups equally.

Adolescent↗
PubMed1972

Polyneuritis and herpes zoster.

Widespread neurological disorders following herpes zoster are exceptional. They include encephalitis and myelitis, and a type of polyneuropathy. The latter is particularly rare as only 16 cases have been described since the first account by Wohlwill in 1924. We present two clinical cases of polyneuropathy following herpes zoster with neuropathological studies on one of them, and discuss its possible aetiology and pathogenesis in the light of previous reports and recent experimental studies.

Adult↗
PubMed1972

Alzheimer's disease in one monozygotic twin.

A woman of 64 died after an illness lasting 15 years and characterized by a progressive amnesic syndrome followed by global dementia. The brain showed changes typical of Alzheimer's disease. Her monozygotic twin sister was clinically not affected and died two years later of carcinoma. This is the second report of monozygotic twin sisters apparently discordant for presenile dementia of Alzheimer type.

Aged↗