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Biomedical subjects

A D Conger

Publications and source records attributed to A D Conger.

29 records · Page 2Linked to original sources
PubMedDate not supplied

Isoproterenol in comparison to WR-2721 as a chemoradioprotector of the rat parotid gland.

A comparison was made of the radioprotective abilities of the chemoradioprotector WR-2721, an amino-thiol, and the beta-sympathomimetic secretogogue isoproterenol on the rat parotid gland. Using the dose-response curve of WR-2721 for gland weights as a basis for comparison, isoproterenol was found to offer significant and equal protection during both the acute (DMF, 2.5) and the chronic (DMF, 2.3) periods.

Amifostine↗
PubMedDate not supplied

Early changes accompanying development of adriamycin resistance in spheroids of a mouse mammary carcinoma line.

The early changes accompanying development of ADR resistance were studied in a mouse mammary adenocarcinoma cell line sensitive to ADR (S). Resistant cells (R) were derived from S by five separate exposures to 1 microgram/ml ADR for 1 hr. The R cells had a 3-fold increased resistance to ADR, a higher proportion of larger cells, higher numbers of chromosomes per cell and higher incidence of minute chromosomes. R spheroids had a higher degree of differentiation. They were more compact, had increased numbers of gap-junctions, and altered membranes. An inversion in the X chromosome in S cells was corrected in the R cells.

Animals↗