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Biomedical subjects

A D Clayden

Publications and source records attributed to A D Clayden.

At least 37 records · Page 2Linked to original sources
PubMed1984

A paradoxical fall in urine dopamine output when patients with essential hypertension are given added dietary salt.

The effect of dietary sodium on the urine dopamine excretion of eight hypertensive patients and six matched controls was studied under metabolic balance conditions over a 2 week period during which dietary sodium intake was increased from 20 to 220 mmol/day. The control group showed the expected increase in dopamine excretion in response to sodium but the hypertensive patients showed an initial fall followed by a return to baseline values. Neither group showed a rise in blood pressure but the hypertensive patients showed a greater weight gain on salt loading, although this change was not significant. The cumulative sodium balance was greater and more prolonged in the hypertensive patients, although this difference also did not attain statistical significance. This defect in dopamine mobilization may be important in relation to renal sodium handling by patients with essential hypertension.

Adult↗
PubMed1983

Failure of renal dopamine response to salt loading in chronic renal disease.

Eight patients with chronic glomerulonephritis and five age-matched normal volunteers were given additional sodium chloride by mouth under conditions of metabolic balance. Whereas in the normal volunteers plasma renin activity was suppressed and urinary excretion of free dopamine increased, in the patients dopamine was not mobilised and plasma renin activity was not completely suppressed. Abnormal retention of sodium and water in glomerulonephritis may be due partly to a failure to mobilise dopamine in the kidney. Specific renal dopamine agonists may be natriuretic and hypotensive in chronic glomerulonephritis.

Adult↗
PubMed1983

The results of pantalar reduction in the management of congenital talipes equinovarus.

One hundred and twenty-five patients with 194 feet affected by congenital talipes equinovarus were treated by the senior author during the period 1959 to 1980. Of these, 70 patients presented either at birth or in the early neonatal period, and 55 were seen later, having been referred from other centres. Seventy-five patients were subsequently reviewed by two of us; the remaining 50 were assessed from records and research files. Patients seen within four weeks of birth were termed "early", the remainder "late". Of the early group of 70 patients, 44 (with 68 affected feet) were reviewed and 26 (with 41 affected feet) were assessed from records. Excellent or good results were achieved in 94 per cent of feet treated conservatively and in 82 per cent of feet which required pantalar release. Of the 55 late referrals 32 patients (with 55 affected feet) were reviewed and 23 (with 30 affected feet) were assessed from records. Satisfactory results were slightly less frequent, but were achieved in 75 per cent of cases. There was no statistical correlation between early soft-tissue release and a good final outcome, but there was a positive statistical correlation between good clinical results and a high talocalcaneal index. Osseous correction (a laterally based wedge tarsectomy or a triple arthrodesis) was necessary at a later date in four feet (four per cent) of those who presented early and in 13 feet (15 per cent) of late referrals.

Adolescent↗
PubMed1982

Screening for the small-for-dates: a clinical and biochemical appraisal.

To find an effective routine screening method for small-for-dates (SFD) infants 500 consecutive patients were recruited at one antenatal clinic. Weight gain during pregnancy, daily fetal movements counts (DFMC) and plasma schwangerschafts protein 1 (Sp1) levels were measured and their efficacy in identifying SFD infant compared. Mothers delivered of SFD infants had a significantly lower weekly weight gain (P less than 0.01) but no significant difference in either DFMC or plasma Sp 1 level. This study shows that epidemiological and clinical data which are inexpensive and easily available at the antenatal clinic are more valuable than more complicated and expensive assays in the prediction of SFD infants.

Adult↗
PubMed1982

Incidence and prevalence of preclinical carcinoma of cervix in a British population.

Quantitative knowledge of the natural history of cancer of the cervix is essential to the design of optimal screening programmes. We have estimated the incidence and prevalence of cervical intraepithelial neoplasia in a population of women receiving cytological examinations, and compared the results with those from other series. Relative risk of disease is reported in relation to easily identified variables (marital status, parity, contraceptive use, symptoms) which are likely to be of practical value in defining selective screening policies.

Adolescent↗
PubMed1978

Seasonal variations in weight of children attending an under-fives clinic in Lesotho.

The incidence of weight loss between successive visits, prevalence of under centile 3 weight-for-age and over centile 97, showed a marked bimodal annual variation for 1243 children attending an under-fives clinic. 9949 weighings on 661 boys and 682 girls over a five year period, contributed to the database. Season of birth also significantly influenced the centile distributions of weight-attained-for-age. Children over 1 1/2 years old showed considerably higher rates of weight loss (about 1 in 5 children attending in their fifth year of life), than children younger than the mean age of weaning. The rates of weight loss, together with seasonal variation, was considerably higher for a group of 'Regular Attenders' to the clinic, than for a group of 'Low Attenders'. Seasonal influences on growth need to be taken into accounts in evaluating the quality of care and outcome produced by under-fives clinics.

Body Weight↗
PubMed1977

A comparison of three systems of classifying presenting problems in general practice.

Three internationally recognized systems have been devised for classifying presenting problems in general practice. They are: the Royal College of General Practitioners' (1963) classification, the US Ambulatory Medical Care Classification of Symptoms (NAMCS), and the World Organization of Colleges and Academies of General Practice/Family Medicine (WONCA, 1976) classification which is known as An International Classification of Health Problems of Primary Care (ICHPPC).These three systems were compared in over 8,000 consultations conducted by 81 randomly selected British general practitioners in Nottinghamshire.For all ages of patient, the NAMCS, which has only 197 categories, was the most specific, and the least specific was the classification of the Royal College of General Practitioners.

Diagnosis↗
PubMed1976

Cross-sectional-type weight reference values for village children under five years in Lesotho.

Cross-sectional-type reference values for weight attained are described for village children under five years in rural Lesotho (formerly Basutoland). Weight measurements derive from observations on 1317 children attending an Under-Fives clinic; it is estimated that 60-70% of the children under five in the catchment area were represented. 4585 weighings on boys and 4826 weighings for girls are included in the analysis. Figures of weight-for-age of boys and girls are given separately as centile distributions suitable for use on Growth Charts. Lesotho 50 centile approximates to 3 centile of British children and slightly exceeds 80% Harvard standard. Weight attained for age is similar, in both sexes, to reports from other less-priviledged urban and rural areas, emphasizing the relative importance of environmental as compared to genetic influences in determining weight-for-age in early childhood. It is suggested that the construction of locally-derived growth reference values is both appropriate and practicable.

Age Factors↗