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Biomedical subjects

A D Allen

Publications and source records attributed to A D Allen.

At least 37 records · Page 2Linked to original sources
PubMed1991

A computer simulation of the natural history of HIV infection: insights and implications.

Computer simulation of the natural history of HIV infection shows that the progression from a silent infection to serious disease need not depend upon any particular biological event but only requires the passage of time. It likewise illustrates why modest efficacy from an antiretroviral agent can go a long way toward treating HIV infection, but a cure will be difficult to develop.

CD4-Positive T-Lymphocytes↗
PubMed1991

Cardiovascular and renal actions of AHR-16303B, an antagonist of 5-HT2 receptors and calcium channels, in hypertensive and normotensive rats.

The cardiovascular and renal responses to AHR-16303B, a novel antagonist of 5-hydroxytryptamine (5-HT2) receptors and calcium channels, were examined in spontaneously hypertensive (SHR) and normotensive rats (NTR) and compared with verapamil and ritanserin. In SHR, AHR-16303B (10-300 mg/kg orally, p.o.) produced dose-related reductions in mean arterial blood pressure (MABP), accompanied by modest isokaliuretic diuresis and unchanged heart rate (HR). In NTR, 10-30 mg/kg p.o. AHR-16303B had no effect on MABP or renal excretory function; 100 and 300 mg/kg reduced MABP but had only transient effects on HR; 100 mg/kg produced antidiuresis in NTR. Both strains of rats tolerated doses of AHR-16303B as high as 300 mg/kg. In both SHR and NTR, verapamil (10-100 mg/kg p.o.) produced dose-related reductions in MABP, antinatriuresis at 60 and 100 mg/kg, and variable effects on HR. Oral ritanserin had no effect on MABP of SHR or NTR at 3 or 10 mg/kg. AHR-16303B is unique in that it simultaneously antagonizes 5-HT2 receptors and produces safe and effective reduction of elevated BP without altering HR or triggering renal compensatory antidiuresis. At effective 5-HT2/calcium antagonistic doses, AHR-16303B has no effect on cardiorenal homeostasis in normotensive animals.

Administration, Oral↗
PubMed1990

Left-right spatial agnosia and other mental defects that characterize clinical researchers.

There are mathematical rules for determining the logical significance of data, just as there are such rules for determining the statistical significance of data. Logical significance reflects the question a study is asking, whereas statistical significance reflects how well it has been answered. Clinical researchers routinely make an incorrect determination as to their study's logical significance because of a spatial (left-right) agnosia. More diffuse cognitive dysfunctions are encouraged by journals that expect clinicians to report on a study as a prerequisite for communicating their pre-existing opinions. The unwillingness or inability of the clinical community to acknowledge this problem reflects a related anosagnosia.

Agnosia↗
PubMed1988

Improvement of four patients with HIV-1 related symptoms after hyperimmunization with killed poliomyelitis (Salk) vaccine.

Four HIV-1 positive patients with characteristic symptoms of this infection experienced amelioration or resolution of symptoms after 2 months of hyperimmunization with inactivated (Salk) poliomyelitis vaccine. The patient who was initially the most symptomatic exhibited a marked improvement in T4/T8 ratio at the sixth month of continued hyperimmunization treatment. With two patients reported previously, six consecutive patients with lymphotropic retrovirus disease have benefited from hyperimmunization with inactivated polio vaccine.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Modeling AIDS and its treatment with immunostimulation.

A mathematical model of AIDS and its response to treatment with immunostimulation therapy is introduced. It correctly predicted the response of an AIDS patient to hyperimmunization with inactivated polio vaccine for a period of four months, indicating that this benign modality will offset the clinical effects of HIV-1 infection for almost a year.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Is RA27/3 rubella immunization a cause of chronic fatigue?

Patients with chronic fatigue syndromes (primary fibrositis syndrome, major affective disorder, etc.) have elevated IgG serum antibodies to multiple common viruses. Only IgG rubella antibodies are positively correlated with the intensity of symptoms and have a height that is clearly significant compared to healthy controls. The lymphotropic properties of the rubella virus could account for the multiple elevated antibodies. Adult women are over-represented in the population of patients with chronic fatigue, and are especially susceptible to developing such symptoms following exposure to attenuated rubella virus. A new more potent strain of live rubella vaccine (strain RA27/3) was introduced in 1979. Within three years reports of patients with chronic fatigue began surfacing in the literature. Considering all this, the possible role of rubella immunization in the etiology of chronic fatigue syndromes deserves further study.

Adult↗
PubMed1987

Clinical improvement of two patients with T lymphotropic retrovirus diseases after polio vaccine hyperimmunization.

Patients with acute leukemia have an impaired ability to produce antibodies to poliovirus in response to inoculation with inactivated vaccine. Reimmunization will, however, produce a relative increase in antibodies equivalent to that of healthy subjects. A child with acute lymphocytic leukemia was hyperimmunized with Salk polio vaccine following a relapse and has had no further relapse nor sequelae for 20 years. An adult physician with acquired immunodeficiency syndrome hyperimmunized himself with the same vaccine, and the preliminary results are encouraging. The clinical improvement seen in these two patients following hyperimmunization with killed polio vaccine may reflect a secondary immune amplification that has been observed in humans following live polio virus immunization.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Depression correlated with cellular immunity in systemic immunodeficient Epstein-Barr virus syndrome (SIDES).

We conducted studies on the peripheral blood of 12 depressed patients with previous diagnoses of mood and/or personality disorders. These patients, and other depressives we observed informally, were resistant to infectious mononucleosis during an epidemic of that illness. All 12 had serologic evidence of a chronic or recrudescent viremia caused by the Epstein-Barr virus (EBV), the infectious agent in infectious mononucleosis. Additional evidence that EBV viremia may be causally related to depression was provided by a strong correlation between the intensity of depressive symptoms and the cellular immune response to the EBV infection.

Antibodies, Viral↗