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Biomedical subjects

A Czech

Publications and source records attributed to A Czech.

63 records · Page 4Linked to original sources
PubMedDate not supplied

[Effectiveness of nifedipine in the treatment of arterial hypertension in various types of diabetes mellitus].

Selection of indications and the general tactics of nifedipine monotherapy of hypertension in diabetic subjects is not clearly established, as yet. It refers specifically to different forms and phases of diabetes mellitus. This was the reason to carry out a respective study. In 4 groups of hypertension: 1) in diabetics without vascular complications, 2) in diabetic nephropathy, 3) in diabetics type II without nephropathy, and 4) in comparative group of subjects without diabetes mellitus, a 6-week controlled, open trial was performed. Before, during and after nifedipine (3 X 10-20 mg p.d.), the following parameters were monitored: 1) systolic, diastolic and mean blood pressures, 2) glycaemic indices of diabetes control, 3) serum cholesterol: total, HDL, LDL, triglycerides, 4) daily albuminuria and GFR, 5) adverse reactions to nifedipine. It could be concluded that nifedipine therapy was relatively most effective and safe in hypertensive diabetics type II without nephropathy. It was less effective in diabetics type I without nephropathy and failed in diabetics type I with nephropathy.

Adult↗
PubMedDate not supplied

[Monotherapy with acebutolol in hypertensive diabetic patients].

Monotherapy of hypertension with acebutolol in diabetics in daily dose of 200-400 mg for 6 weeks induced only non-significant and practically not acceptable hypotensive effect in groups of patients with hypertension and diabetes type I or type II without nephropathy. No therapeutical effect was observed in hypertension in diabetics type I with nephropathy. Administration of acebutolol to hypertensive diabetic patients with nephropathy resulted in tendency to increase in albuminuria. Values of creatinine clearance did not change at the same time. Also no effect of acebutolol on glycemic or lipid indices was observed. The lack of clear hypotensive effect under studied conditions of acebutolol in diabetic patients contrasted with its significant action in comparative group of hypertensive non-diabetic subjects.

Acebutolol↗
PubMedDate not supplied

Modification of gas-chromatographic method for blood chlorpropamide determination and evaluation of its use for clinical and pharmacological purposes.

A gas-chromatographic method for isolation and determination of blood chlorpropamide, described originally in literature [10], was modified and its usefulness for clinical and pharmacological purposes evaluated by testing fluctuations in blood chlorpropamide concentration with time in healthy subjects (control group) and patients with type II diabetes mellitus, in relation to glycemia and insulinemia (IRI). In this respect the effects of a single dose and of prolonged chlorpropamide therapy were studied. Large individual variability in the time-related concentration curves and no statistically significant correlation between chlorpropamide, insulin and glycemia were noted.

Adult↗
PubMedDate not supplied

[Principles of hypotension treatment in patients with diabetes].

Epidemiological studies have revealed, that elevated blood pressure is in diabetics 1.5-3.0-times more frequent that in general population. It is one of the most important factors increasing the morbidity and mortality due to small and big arteries disease. Hypotensive therapy should be commenced in diabetic persons earlier than in patients without diabetes mellitus. In many such diabetic patients blood pressure normalization could be obtained by dietary adaptations and metabolic compensation. In more advanced cases pharmacological treatment should be undertaken. When selecting the drug for a diabetic person one has to balance between positive and adverse actions. The drugs of the first choice are the ACE inhibitors, drugs blocking the slow calcium channel and alpha 1-adrenergic receptors, because they do not influence negatively the carbohydrate and lipid metabolism. On contrary, prazosin and ACE inhibitors increase the tissue sensitivity to insulin. The latter group decrease also intraglomerular pressure and albuminuria. As a routine the treatment begins with small, testing dose of a single hypotensive drug. The dosage may be increased slowly up to the average dose level. If this manipulation does not permit normalization of blood pressure one may combine 2 or 3 hypotensive drugs. Selection of the drug and of its dose rely also on the type and intensity of late diabetic complications--at first nephropathy and autonomic neuropathy.

Diabetic Angiopathies↗
PubMedDate not supplied

[Basal and reactive renin and aldosterone secretion in arterial hypertension of insulin dependent diabetics].

The aim of the study was to assess the significance of the renin-angiotensin-aldosterone system (R-A-A) in the pathogenesis of arterial hypertension in patients with diabetes type I (IDDM). Testing was accomplished in the hospital conditions in a group of 131 patients with long-term IDDM, who beside of diabetes mellitus and its chronic complications did not show any symptoms of additional diseases. The patients were divided in 5 groups (A-E) depending on the type of coexisting late diabetic complications. The control group was consisted of 20 healthy persons matched for sex and age. In each case the following tests were performed: measurement of blood pressure in succumbent position, daily profile of glycemia and glucosuria, Hb A1 level, ophthalmoscopy, functional assessment of kidney and autonomic system status. Tenin activity in plasma (ARO) and plasma aldosterone (ALD) were determined in basal (after 6 h of succumbent position) and after i.v. administration of 40 mg of furosemide and 3 h of standing position (reactive values). In all groups under study the significant decrease of average, basal and reactive ARO was found in comparison with the control group. This abnormality was the most distinct in subjects with diabetic nephropathy. The autonomic neuropathy was abolishing this tendency. The mean concentration ob basal ALD was in all diabetic subgroups similar as in the controls. The mean reactive ALD was however significantly decreased. In diabetes complicated by retinopathy the negative correlation between ARO and systolic, diastolic and mean blood pressure existed. In diabetes complicated by nephropathy the dependence between blood pressure and ARO and ALD was not found.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗