Biomedical subjects
Publications and source records attributed to A Czarnecki.
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We describe a new approach to computing energy levels of a nonrelativistic bound state of two constituents with masses M and m, by a systematic expansion in powers of m/M. After discussing the method, we demonstrate its potential with an example of the radiative recoil corrections to the Lamb shift and hyperfine splitting relevant for the hydrogen, muonic hydrogen, and muonium. A discrepancy between two previous calculations of O(alpha(Zalpha)5m2/M) radiative recoil corrections to the Lamb shift is resolved and several new terms of O(alpha(Zalpha)5m4/M3) and higher are obtained.
Our aim was to determine whether the expression of K(+) currents is related to the cell cycle in the excitable GH3 pituitary cell line. K(+) currents were studied by electrophysiology, and bromodeoxyuridine (BrdU) labeling was used to compare their expression in cells thereafter identified as being in the S or non-S phase of the cell cycle. We show that the peak density of the transient outward K(+) current (I(to)) was 33% lower in cells in S phase (BrdU+) than in cells in other phases of the cell cycle (BrdU-). The voltage-dependence of I(to) was not modified. However, of the two kinetic components of I(to) inactivation, the characteristics of the fast component differed significantly between BrdU+ and BrdU- cells. Recovery from inactivation of I(to) showed biexponential and monoexponential function in BrdU- and BrdU+ cells, respectively. This suggests that the molecular basis of this current varies during the cell cycle. We further demonstrated that 4-aminopyridine, which blocks I(to), inhibited GH3 cell proliferation without altering the membrane potential. These data suggest that I(to) may play a role in GH3 cell proliferation processes.
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History and current status of monitoring of adverse drug reactions in Poland is presented. The Centre for Monitoring of Adverse Drug Reactions (ADR) was established in 1971. The number of suspected drug reactions reported varied in subsequent years. In the analysed periods of time 1972-1984 and 1985-1994, 956 and 961 reports were received respectively. Due to the small number of reports, in the course of the years many different activities were undertaken with variable rates of success. It is recognized that much effort and time is needed to increase awareness of the necessity of drug safety monitoring in the medical profession. Therefore major reorganization of the ADR monitoring system with regional centres is planned.
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The comparative analysis of treatment pattern prescribed by general practitioners (GPs) and cardiologists for ischaemic heart disease and arterial hypertension to 1835 patients was performed. It was found that both cardiologists and GPs followed similar treatment regimens although nitrates were more extensively prescribed by GPs. The effectiveness of treatment evaluated according to standardized criteria was comparable but GPs were less effective in cases where monotherapy was prescribed. The overall reporting of adverse effects of drugs (ADRs) was low.
On the basis of 1501 "Drug Disposal Charts" a comparative analysis was carried out of treatment schemas of ischaemic heart disease and arterial hypertension used by cardiologists and regional general practitioners, taking into account the effectiveness of treatment. Besides that the frequency was analysed of the reports by doctors on adverse reactions occurring during treatment.
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