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Biomedical subjects

A Cuschieri

Publications and source records attributed to A Cuschieri.

At least 379 records · Page 21Linked to original sources
PubMed1975

The development of the olfactory mucosa in the mouse: light microscopy.

The development of the olfactory and vomeronasal epithelia of the mouse has been investigated from the 9th day of gestation until shortly after birth. On the 10th day axons emerge from the base of the olfactory epithelium to reach the olfactory bulb primordia on the 11th day, at which time the olfactory dendrites first appear. On the 13th day a distinction between the elongate nuclei of the embryonic stem cells and the rounded nuclei of the differentiating receptors is visible. A basal layer of stem cells remains mitotically active from the 13th day of gestation onwards, and after the 15th day the majority of mitoses occur in this layer. It is suggested that from the 15th day of gestation onwards the nuclei situated most apically become those of the supporting cells. The glands of Bowman are first visible on the 17th day of gestation. The diverticulum of the vomeronasal organ begins to form on the 11th day and the development of its sensory epithelium resembles that of the olfactory organ except for the absence of basally situated stem cell nuclei in the later stages of the vomeronasal organ.

Animals↗
PubMed1975

The development of the olfactory mucosa in the mouse: electron microscopy.

The development of the olfactory epithelium from the 10th day of gestation of postnatal life has been examined electron miscroscopically in the mouse. At 10 days' gestation the epithelium is already differentiated into dark and pale cells, the former representing embryonic stem cells and the latter the developing receptors. Axons are also visible at this stage. At 11 days the first signs of dendrite formation appear, and at 12 days spheroidal terminal swellings containing numerous microtubules are present at the apices of receptor dendrites. Centriole clusters also appear in the receptor cell bodies and dendrites. From the 12th to the 16th day of gestation a few cilia are formed on the receptor endings. Final steps in the maturation of differentiating receptors begin on the 17th day of gestation, when membranous organelles and lysosomes increase greatly in numbers. However, immature receptors can still be found in the base of the epithelium in postnatal life. Supporting cells are first recognizable on the 17th day of gestation, derived apparently from the remaining stem cells. At the same time differentiated basal cells and glands of Bowman begin to appear. In the early develoment of the olfactory nerve bundles the axons have large and varying diameters, but later on axonal sizes are progressively reduced and the adult size range is achieved at about 18 days of gestation. The significance of these findings is discussed.

Age Factors↗
PubMed1975

Value of laparoscopy in hepatobiliary disease.

A prospective study was made of the value of laparoscopy in hepatobiliary disease. The pathology was accurately diagnosed by laparoscopy alone in 21 out of 33 consecutive cases of cholestatic jaundice (36% failure rate). Laparoscopy gave a slightly better diagnostic yield for secondary tumour deposits than hepatic scintiscanning, and the simultaneous use of both procedures reduced the false negative rate to 2/18 (11%). Laparoscopic liver biopsy was superior to blind percutaneous biopsy in the retrieval of secondary malignant tissue, but it had no obvious advantage over the latter when performed on patients with diffuse disease (cirrhosis) or primary hepatic tumours.

Adult↗