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Biomedical subjects

A Creutzig

Publications and source records attributed to A Creutzig.

At least 127 records · Page 7Linked to original sources
PubMed1987

Temperature-dependent laser Doppler fluxmetry in healthy and patients with peripheral arterial occlusive disease.

Laser Doppler flux (LDF) was determined at the forefoot in 17 healthy volunteers and 16 patients with mild peripheral arterial occlusive disease. LDF was assessed simultaneously by two probes, one was unheated and the other was run with a probe holder temperature of 37 degrees C. During occlusion of the venous circulation a decrease between 43 and 61% was recorded in both groups and at both temperatures. When the leg was elevated there was an increase of about 60% in unheated skin; at 37 degrees C LDF was impaired significantly in patients. During leg dependency LDF decreased in 15 of the volunteers by 44 and 50% which is the result of the physiological vasoconstrictor response. In patients there was a decrease in unheated skin in 12 cases, in heated skin only in 8 cases. When pure oxygen was inhaled, LDF was unchanged in probands, but increased in patients when measured at 37 degrees C. Reactive hyperaemia flow was about three times higher in unheated skin than in heated skin. Reproducibility was best during leg elevation and was more reliable for measurements at 37 degrees C. Rhythmical variations had a frequency of about 4 cycles/min in healthy subjects and 2.6 cycles/min in patients. As a rule, in both groups frequencies at 37 degrees C were higher as compared with unheated skin. Patients had lower frequencies than probands at both temperatures. During intraarterial application of two differently acting drugs quite different reactions of LDF could be recorded. Measurements of LDF at 37 degrees C made differences between patients with PAOD and healthy volunteers more obvious. Moreover, vasomotional changes in skin blood flow could better be studied at this temperature.

Adult↗
PubMed1987

Transcutaneous oxygen pressure measured at two different electrode core temperatures in healthy volunteers and patients with arterial occlusive disease.

The influence of two different electrode core temperatures on transcutaneous oxygen pressure (tcPO2) was studied in ten probands and 28 patients with peripheral arterial occlusive disease. Hyperaemisation of skin by an electrode core temperature of 44 degrees C reflects local hyperaemia flow and can be reproduced constantly. At 37 degrees C low tcPO2 values are recorded which are in good accordance with mathematically calculated capillary dome PO2. According to great physiological alterations in skin perfusion tcPO2 (37 degrees C) varies in wide ranges. This mode of measurement is well suited to study physiological autoregulation mechanisms or the influence of drugs on skin perfusion. The herein reported results are: forefoot tcPO2 (37 degrees C, 44 degrees C) in volunteers is significantly higher than in patients; forefoot tcPO2 (37 degrees C, 44 degrees C) of patients with diabetes mellitus is significantly higher than in nondiabetics; prestenotic tcPO2 (37 degrees C, 44 degrees C) is about two times higher than poststenotic tcPO2 (37 degrees C, 44 degrees C); tcPO2 (37 degrees C) in probands decreased significantly during occlusion of the venous circulation; tcPO2 (44 degrees C) increased in probands and patients when standing up; however, tcPO2 (37 degrees C) decreased in healthy persons and increased in patients when standing up; after a 5-min suprasystolic cuff occlusion of the arterial circulation there was a four- to six-fold increase of tcPO2 (37 degrees C) which indicates reactive skin capillary flow. In conclusion tcPO2 (37 degrees C) permits measurement of relative changes of skin capillary flow under physiological conditions so that autoregulating mechanisms can be studied.

Adult↗
PubMed1986

Effects of intra-arterial prostaglandin E1 in patients with peripheral arterial occlusive disease.

The effects of intraarterially administered prostaglandin E1 (PGE1) on macrocirculatory, microcirculatory and metabolic parameters in patients with peripheral arterial occlusive disease were studied. Nutritive calf muscle blood flow, as determined with the xenon-clearance technique, and muscle tissue oxygen pressure increased markedly in patients with obliterations of the femoral artery. Transcutaneous PO2 as indicator for cutaneous blood flow increased in prestenotic regions dose-dependently whereas there was a clear poststenotic decrease during the infusion period. High lactate/pyruvate ratios in the femoral vein were significantly decreased by PGE1 treatment. PO2 in the femoral vein increased significantly. Thus, PGE1 has some beneficial effects on muscle circulation in these patients.

Adult↗
PubMed1986

[Radiologic diagnosis of thoracic outlet syndrome and its vascular complications].

The term "Thoracic Outlet Syndrome" (TOS) applies to all neurological and vascular symptoms caused by compression of the nerves and vessels situated in the outlet (inlet) of the thorax and the costoclavicular area. The clinical and radiological results of 20 patients with acquired and congenital TOS are presented and the relevant literature is reviewed. The different radiological findings of plain chest X-ray, phlebography, intravenous DSA and arteriography are demonstrated with special emphasis on the vascular complications of TOS.

Adolescent↗
PubMed1985

[Ergotism].

Explore the source record for details and available documents.

Ergot Alkaloids↗
PubMed1985

Muscle tissue oxygen pressure in patients with arterial occlusive disease.

Oxygen pressure histograms were determined with the multiwire surface electrode from the gastrocnemius muscle in patients with arterial occlusive disease and compared with those of healthy volunteers. Seven out of 22 patients had normally distributed histograms like volunteers, but the mean PO2 values were lower than the total mean value of the volunteers. Fifteen patients showed scattered histograms with dominating low PO2 values. Ten out of 11 patients suffering from diabetes mellitus had scattered histograms. When perfusion pressure was impaired by elevating the leg or the musculature was stressed in 7 patients the histograms' form of all these patients changed significantly. Median PO2 fell in all cases with clinically decompensated occlusive disease. Percutaneous transluminal angioplasty of an occlusion of the superficial femoral artery led to a significant shift of the histogram to higher PO2 values. The scattered histograms of patients suffering from arterial occlusive disease are thought to be caused by an inhomogeneous blood flow probably induced by the closure of arterioles.

Angioplasty, Balloon↗
PubMed1985

Drug-induced alterations in muscle tissue oxygen pressure in patients with arterial occlusive disease.

Muscle tissue oxygen pressure fields were examined on the surface of the gastrocnemius muscle of 17 patients with peripheral arterial occlusive disease before and during intra-arterial administration of dextran 40 50 ml/50 min, xantinolnicotinate 600 mg ad 50 ml NaCl 0.9%/50 min and prostaglandin E1 1.0-2.5 ng/kg/min ad 50 ml NaCl 0.9%/50 min. Median PO2 increased in 6 out of 7 patients up to 214% when dextran 40 was given and up to 300% in all 5 cases who received prostaglandin E1. In some patients the histograms' distribution type changed during the treatment from a scattered form which indicates microcirculatory disorders to a bell-shaped form which is expected when microcirculation is undisturbed. Intra-arterial administration of xantinolnicotinate was without any influence on poststenotic muscle PO2. The registration of muscle tissue oxygen pressure fields is an ideal method for determining the effect of so called vasoactive drugs in treatment of peripheral arterial occlusive disease.

Adult↗
PubMed1985

[Heart and skeletal muscle scintigraphy with thallium 201].

The regional uptake of Thallium-201 is correlated with the regional distribution of cardiac output in the myocardium as well as in skeletal muscle. Thallium-201 perfusion scans will detect peripheral occlusive arterial disease (POAD) as well as coronary heart disease (CHD). In a prospective study we examined POAD patients and CHD patients by both myocardial and leg stress scintigraphy. In normals the uptake ratio of both calves was 1.03 +/- 0.05 (mean +/- SD), while in all patients with proven POAD the ratio was higher than 1.2. In 12 of 16 patients with myocardial infarction the high ratio indicated a coincidence of POAD and CAD, confirmed by other techniques in all but one patient. In patients with suspected CHD there was an increased ratio in 8 of 21;6 of these patients also had an abnormal myocardial stress scan, while there were only 4 abnormal scans in the 13 patients with normal leg uptake. In 19 of 26 patients with known POAD the myocardial stress scan was abnormal, indicating CHD in 75% of this group. This was confirmed in most patients by coronary angiography. The combination of myocardial and leg stress scan can be carried out without further radiation exposure to the patient and in a few minutes. It is a new approach to determine the possible coincidence between POAD and CHD; it should be performed in all patients referred for TI-201 myocardial stress scintigraphy.

Arterial Occlusive Diseases↗
PubMed1985

[Ergotamine-induced disorders of the peripheral blood circulation--a case report].

Ergotism with severe arterial circulatory disorders, sometimes leading to amputation of the leg, is a severe complication following application of drugs containing ergotamine. Often the diagnosis is made by the typical angiographic findings. The history, clinical course and a new treatment in a very severe case is reported.

Adult↗
PubMed1985

[Oxygen pressure fields in ulcers of the lower leg].

Using a multi-wire surface electrode, oxygen pressure fields were determined in leg ulcers of 11 patients with chronic venous insufficiency (cvi). In three of them, cvi was combined with arterial occlusive disease. The histograms of all patients with very low PO2 values revealed microcirculatory disturbances of the ulcer tissue. The influence of leg position is reflected in the histograms. Patients with cvi showed higher PO2 values when the leg was raised in comparison with when it was in the hanging position. The patients with mixed ulcerations showed a significant increase in tissue PO2 when the leg was in the hanging position, which shows the importance of arterial perfusion pressure. After a compression bandage had been applied to the legs with cvi, the tissue oxygen pressure of the ulcers increased markedly, probably as a result of diminished blood stasis. These results can be explained either by a rarefaction of capillaries in the ulcer tissue or by fibrin diffusion barriers around the capillaries. The changes in the histograms after bandaging are thought to be caused by an improvement in venous circulation.

Adult↗
PubMed1984

[Digital subtraction angiography for the follow-up control of percutaneous transluminal angioplasty using a scoring system].

Seventy-two patients were examined by venous DSA following angioplasty, 28 of these within three weeks and 44 six months to three years after the procedure. The resolution of the DVI 2 V is adequate for showing reparative changes after dissection in the short-term follow-up. Demonstration was sufficient to enable one to use a coding system which classified the type and severity of the vascular changes. Clinical and angiographic follow-up showed good agreement regarding the amount of improvement obtained; in these patients, clinical follow-up alone is adequate. Where there has been no change in the clinical state or if there has been deterioration, a DSA examination should be carried out in order to ascertain the reason for the lack of improvement.

Angiography↗