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Biomedical subjects

A Couture

Publications and source records attributed to A Couture.

65 records · Page 4Linked to original sources
PubMed1979

[Discitis in small children (author's transl)].

Discitis was diagnosed in 5 children under 3 years of age, the initial clinical manifestations being difficulty in walking and abdominal pains in one case. Diagnosis was not made before periods varying from 8 days to 3 months, and no etiological basis for the disease was discovered. Pinching of the disc was always present in the first radiographic image, and the vertebral plate was ill-defined in 3 cases. Repeat radiological examinations were carried out in 3 children after 6 months, 2 and 5 years respectively. There was partial restauration of the disc space in 2 cases; the last one presented signs of late collapse after early recuperation. Early perilesional bone sclerosis was noted in 2 cases, while it was posterior and late in one child. There were no sequelae (fusion, vertebra plana, scoliosis). Two investigations are essential if a disc lesion is suspected: -- radiography of the spinal column, even if there are no disturbances in walking or abdominal pains. -- scintigraphy with technitium 99, which is the only means of establishing an early diagnosis.

Child, Preschool↗
PubMedDate not supplied

[Photophysical evaluation of photosensitization by various quinolones].

An original physicochemical method is proposed for the evaluation of the photosensitizing activity of drugs in vitro. A Nuclear Magnetic Resonance (NMR) spectrum is recorded during light irradiation of drug solutions. The change in the intensity of the NMR lines under such conditions is termed the Photochemically Induced Dynamic Nuclear Polarization (Photo-CIDNP) effect. It is related to the formation of radical intermediates which may be involved in the in vivo photosensitization reactions (the so-called type-I photoreactions). Nine commercial quinolones were tested by this method: nalidixic, oxolinic, pipemidic and piromidic acids, rosoxacin, flumequine, enoxacin, pefloxacin and norfloxacin. Each quinolone was irradiated in alcoholic solutions in its UV absorption band (300-350 nm) in the absence or in the presence of a biological target chosen as a model: the amino-acid N-acetyltyrosine. The quinolones were classified in two groups in relation to the intensities of the observed CIDNP effects. Nalidixic and oxolinic acids, rosoxacin and flumequine are among the most potent photosensitizers.

Chemical Phenomena↗
PubMedDate not supplied

[Value of echoencephalography through the fontanelle in neonates and infants (author's transl)].

Echoencephalography through the fontanelle provides a complete scan of the head allowing the study of the ventricular system and cerebral parenchyma. The closure of the anterior fontanelle is the only limiting factor for this remarkably innocuous technique which is easy to perform (even in neonates under artificial ventilation in incubators), easy to repeat and relatively cheap. The authors report the results of 700 ultrasonic examinations carried out in 467 children. The echostructure of the brain, is studied in detail in 70 normal subjects (30 prematures, 31 at term neonates and infants under 1 year of age). In a population of 397 sick children the abnormal pictures were analysed according to clinical circumstances: perinatal distress (n = 107), prematurity (n = 81), hydrocephalus (n = 31), malformations (n = 9)... Our results confirm the usefulness of this technique for the early anatomic evaluation of any high-risk brain and for the follow-up of the lesions. The respective values of echography through the fontanelle, transcranial echography and computed tomography are discussed.

Brain↗