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Biomedical subjects

A Correa

Publications and source records attributed to A Correa.

At least 55 records · Page 3Linked to original sources
PubMed1990

Influence of jejunal hypertonic glucose infusion on sham-feeding-stimulated gastric acid secretion: evidence of a defective mechanism in duodenal ulcer patients.

The aims of the present study were to determine in 14 healthy subjects and 14 duodenal ulcer patients the reproducibility of the acid secretory response to a modified sham-feeding test and the effect on this response of intrajejunal hypertonic glucose instillation, in order to evaluate the possibility of the existence of a defective inhibition of the cephalic phase of gastric acid secretion in duodenal ulcer disease. The reproducibility of the acid secretory response to a modified sham-feeding test was demonstrated in both groups in two consecutive tests. The hypertonic glucose instillation produced a significant inhibition of the acid secretory response to modified sham feeding only in the healthy subjects, suggesting that duodenal ulcer patients may have a defective mechanism of acid inhibition during vagal stimulation by modified sham feeding. Non-significant changes were observed in plasma gastrin and pancreatic glucagon levels.

Adult↗
PubMedDate not supplied

Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study.

BACKGROUND: In February, 1999, a local US health department identified a cluster of pertussis cases among neonates born at a community hospital and recommended oral erythromycin for post-exposure prophylaxis for about 200 neonates born at that hospital between Feb 1 and Feb 24, 1999. We investigated a cluster of seven cases of infantile hypertrophic pyloric stenosis (IHPS) that occurred the following month among the neonates who had received erythromycin. METHODS: We obtained a masked, independent review of the IHPS ultrasonography diagnoses, calculated the monthly IHPS incidence, and compared index and historical (1998-99) IHPS cases with respect to several characteristics including erythromycin exposure. We used a retrospective cohort of infants born in January and February, 1999, to investigate further erythromycin exposure and development of IHPS. FINDINGS: An independent review confirmed the ultrasonographic diagnoses of all seven index IHPS cases. All index cases versus none of the historical IHPS cases had been given erythromycin for pertussis prophylaxis. The IHPS rate for infants born in the hospital in February, 1999, was 32.3 per 1000 liveborn infants, representing nearly a seven-fold increase over 1997-98 (relative risk 6.8 [95% CI 3.0-15.7]). Among infants born in January and February, 1999, erythromycin was associated with IHPS (absolute risk 4.5%, relative risk infinity [1.7-infinity]). INTERPRETATION: Neonates receiving oral erythromycin may have an increased risk of IHPS. The risks and benefits of erythromycin for neonatal pertussis prophylaxis should be re-evaluated, and caution should be used in defining risk groups for prophylaxis.

Administration, Oral↗
PubMedDate not supplied

[Severe myoclonic epilepsy in childhood. Epidemiologic analytical study].

INTRODUCTION AND OBJECTIVE: Severe myoclonic epilepsy in infancy (SMEI) is a relatively rare disorder which etiology is unknown. The descriptive epidemiologic study tries to find the exposure agents or other circumstances present in affected children. Were have studied this agents and circumstances in 28 children with SMEI. PATIENTS AND METHODS: The study included 28 children, 17 girls and 11 boys, diagnosed of SMEI. Patients were selected according to the criteria established by Dravet et al in 1984. For each patient, the following features were studied: sex, parents age, prenatal antecedents, perinatal antecedents, new born stage, psychomotor development until the first convulsion, country/urban social class, family history of epilepsy and for febrile seizures, and cause of the first seizure. RESULTS: All parents are young adults, between 25 and 40 years at the birth of the child. The number of the fratry is between the first and the fourth. There is no pre and perinatal antecedents. The birth's weight is between 1,800 g and 4,600 g (X: 3,580 g). In 16 children (57.15%), the first seizure appeared after any dose DTP vaccination, frequently the second. Familial antecedents existed for epilepsy in nine cases and for febrile convulsions in six cases. CONCLUSIONS: The more interesting findings are the high percentage of cases that have the first convulsions after any dose of vaccination DTP and the high percentage of cases with family history of epilepsy and/or febrile seizures. It suggests that in pathogenesis of the SMEI there is a constitutional factor or predisposition genetically conditioned in relation to immunological disorders or to a multifocal cortical microdysgenesis, possibly triggered by toxic-allergic factors.

Brain↗
PubMedDate not supplied

[Molecular characterization of rotavirus in the city of Santafé de Bogotá, Colombia. Determination of the electrophenotypes and typing of a strain by RT-PCR].

131 diarrheic samples obtained from children taken to the emergency room of the Misericordia Hospital in Santafé de Bogotá were cultivated for rotavirus. These virus were found to be etiological agents for the diarrhea in 42 (32%) of the patients. In order to characterize electrophoretically the rotavirus they were cultured in cell line MA-104, total RNA was extracted and subjected to electrophoresis in SDS-PAGE and then the retrotranscription polymerase chain reaction. Eight different electrophoretic patterns were found. All patterns correspond to group A. Eight positive PAGE samples and the control type RRV were cultured in cell line MA-104. Viral growth was found only in the control and four of the samples. Total RNA was extracted from all five infected cultures and gene 9, which codifies for protein VP7 was amplified. All four samples and the control were shown to be G3. The finding of eight different electrophoretic types, all of them belonging to group A, show a diversity in co-circulating rotavirus strains. These findings contribute to a better understanding of viral acute gastroenteritis natural history and should help in developing new epidemiological vigilance strategies, prevention and control of rotavirus in children population of Santafé de Bogotá.

Cell Line↗
PubMedDate not supplied

[Significance of comorbidity in the control of the quality of treatment of dialysis patients].

The Uruguayan Dialysis Registry (UDR) is an obligatory registry and includes all the patients on dialysis treatment in the country. The dialysis prevalence rate at 12-31-1997 was 604 pmp and the mortality rate in 1997 was 132 deaths per 1,000 patient years at risk. Adjusted mortality of each dialysis center in the country (n = 35) is calculated every year. In this paper, mortality in the different centers was compared applying the usual methodology in order to identify centers with higher mortality and the importance of comorbidity m the mortality comparison among centers was analyzed. 1. The prevalent and incident population of the 1992-1996 period was considered (n 2989). The mortality rate of each dialysis center, adjusted for age and nephropathy by indirect standardization, was calculated. The prevalent and incident population (1985-1991) of the UDR was used as standard. Standardized mortality rate (SMR) for each center and for the total population was obtained dividing observed deaths by expected deaths. 2. The prevalent population at january 1, 1994 was considered (n 1131) and the observation period was extended from january 1, 1994 to december 31, 1997. Demographic and co-morbidity data were collected at the start of the observation period. Multivariate analysis of survival was applied to identify significant risk factors (Cox hazard regression model). The mortality rate of each dialysis center was adjusted for the significant risk factors. Seven centers had significant higher mortality rate adjusted for age and nephropathy than the average of the standard population. Four year survival in the 7 centers (51.6%) was lower than in the other 28 centers (63.6%) (p = 0.0001). In the multivariate analysis, 5 variables (age, diabetes, arteriosclerotic heart disease, cerebrovascular disease and peripheral vascular disease) were significantly related with mortality. The relative risk of death, adjusted for the five significant risk factors showed higher significant mortality only in four centers. Three centers did not show mortality differences with the other centers when mortality was analyzed in the multivariate analysis with the significant risk factors. We concluded that adjusting the mortality rate to the significant risk factors allow to discriminate if the differences observed among centers are related or not to an unequal distribution of the risk factors.

Humans↗
PubMedDate not supplied

[Schwannoma of the spinal nerve].

A years old woman with a spinal nerve schwannoma is reported. Treatment and main clinical and histopathologic features of this very unusual location are discussed.

Adult↗