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Biomedical subjects

A Constantinescu

Publications and source records attributed to A Constantinescu.

At least 55 records · Page 3Linked to original sources
PubMed1987

Temperature dependence of the effects of tertiary amines on osmotic hemolysis.

The effects of four tertiary amines (procaine, lidocaine, tetracaine and dibucaine) on the osmotic fragility and the rate of hemolysis of human erythrocytes were investigated in the range between 22-42 degrees C. The temperature dependence of the relative hemolysis indicates the existence of certain critical points in the antihemolytic effect of these substances. The relative rate of hemolysis, which is well known to be a parameter accounting for the fluidity of erythrocyte membrane, decreases with increasing drug concentration, indicating a decrease in membrane fluidity. The amount of drugs actually bound to the erythrocytes increases linearly with the external concentration, as shown by UV-absorption.

Amines↗
PubMed1982

Glutaraldehyde effect on the osmotic fragility and rate of haemolysis of human erythrocytes: a kinetic study.

The effect of glutaraldehyde treatment on the osmotic fragility and rate of haemolysis of human erythrocytes was studied in the temperature domain 22-42 degrees C at different aldehyde concentrations from 0.010 to 0.040% (w/v). The osmotic fragility linearly decreases at increasing temperatures for all glutaraldehyde concentrations with approximately the same slope as for the untreated erythrocytes. Rather similar effects are produced on the rate of haemolysis. It was not possible to define unique activation energies. The maximal haemolysis becomes smaller after the treatment with increasing concentrations of glutaraldehyde but more erythrocytes are no longer able to tolerate normally non-haemolysing osmotic stretching, this suggesting an artificial "ageing" of erythrocytes. The formation of a membrane protein skeleton as a result of cross-linking is inferred, while the changes in the cytoskeletal spectrin network seem to be less important.

Aldehydes↗
PubMed1977

Spinal dissemination following operation on cerebral oligodendroglioma.

This paper concerns two cases of cerebral oligodendroglioma (intraventricular in one case, right temporal in the other), with spinal dissemination (cervical and upper thoracic respectively), manifested clinically 2 years and 14 months respectively after removal of the cerebral tumour. Anatomical examination confirmed the diagnosis of disseminated oligodendroglioma in the leptomeninges in both cases and also in the parenchyma in the second case.

Adult↗
PubMed1977

Haematological aspects of hypophyseal tumours.

This paper is devoted to the study of anaemia in patients with hypophyseal tumours. Anaemia with a red blood cell count of 2.4 million/mm3 to 3.9 million/mm3 was found in 60 of 280 patients (21.7%) with hypophyseal tumours; 52 of the 60 patients were operated on. Similar changes were observed in 25 of 60 cases (41.7%) of craniopharyngioma. Apart from anaemia and a low haemoglobin some of the patients also had anisocytosis, anisochromia, leucocytosis, and haemolytic shock.

Adolescent↗
PubMed1977

Spinal dermoid tumours.

The present work is a detailed analysis of 12 cases of spinal dermoid tumours operated on between 1935 and 1976. Of these 11 were medullary (3 intramedullary and 8 subdural extramedullary), representing an incidence of 0-80% of medullary tumours, and 1 was an extraspinal coccygeal tumour. Most of the tumours were located in the spinal canal and conus. Good results were obtained following total ablation in 7 cases and partial removal of the tumour in 5 cases.

Adolescent↗
PubMed1977

Cranial eosinophilic granuloma.

Investigations were carried out on 27 cases of cranial eosinophilic granuloma: 16 males (59%) and 11 females (41%). The mean age was 25 years, the extremes being 2 years and 65 years. The location in 21 cases (80%) was exclusively in the calvarium (9 frontal, 8 parietal, three occipital and 1 temporal), orbital in two cases, fronto-orbital one case, base of the skull in the left parasellar region one case, left frontal subdural with chronic subdural haematoma one case and one case left occipital and petrosal bone. All the cases were diagnosed histologically. In 18 cases the tumour was removed at operation. Recurrences occurred in four of these cases (15%), three of whom died (11-5%). Four of the patients received steroid therapy and four steroid therapy combined with X-ray therapy. The evolution was favourable in all these cases.

Adolescent↗
PubMed1976

Supratentorial dissemination of medulloblastomas.

The present paper reports on 13 cases of medulloblastoma with supratentorial dissemination. With reference of these cases the authors discuss the pathogenetic probabilities of the dissemination of brain tumors, their evidence and treatment, emphasizing the importance of cerebral scintigraphy formed periodically in all patients previously operated of medulloblastoma. When dissemination is detected radiotherapy may give good results. If the symptomatology is very accentuated the secondary supratentorial tumour has to be removed.

Adolescent↗
PubMed1975

Neurinomas of the trigeminal nerve.

Neurinomas of the trigeminal nerve are rare tumours. Six cases of a series of 8,894 intracranial tumours operated upon in the Neurosurgical Clinic of Bucharest are reported. The literature is reviewed. One hundred one other cases have been found. The signs and symptoms produced by these tumours, their slow development, the radiological and other diagnostic findings, the treatment and the prognosis are discussed.

Adult↗