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Biomedical subjects

A Claudy

Publications and source records attributed to A Claudy.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

[Correction of facial lipoatrophy with a biodegradable material in HIV-infected patients].

INTRODUCTION: Facial lipoatrophy in HIV-infected patients under tri-therapy occurs frequently and alters their quality of life. No systemic treatment is capable of curing this problem. PATIENTS AND METHODS: Eighty-one patients were included in an open, prospective, compassionate study. A strict intradermal injection of a biodegradable, polyacrylamide cationic copolymer was administered in several sessions. RESULTS: In all the patients, the correction of the facial lipoatrophy was considered satisfactory and stable over a period of 6 months using comparative photographic clichés. The thickness of the dermal skin, assessed by sonography, was doubled. No local or systemic side effect was reported. CONCLUSION: Our study shows that is it possible to durably correct the facial lipoatrophy of HIV-infected patients under tri-therapy by using a biodegradable implant.

Acrylic Resins↗
PubMedDate not supplied

Vulvar cicatricial pemphigoid of childhood.

We report a 9-year-old girl with a vulvar autoimmune bullous dermatosis. A diagnosis of localized bullous pemphigoid or cicatricial pemphigoid was made on the basis of immunohistologic data. Since the lesions were unresponsive to topical corticosteroids but healed completely on dapsone at a dosage of 1.5 mg/kg/day, we favor the diagnosis of vulvar cicatricial pemphigoid. Only two such cases have been reported thus far. The diagnostic criteria and therapeutic modalities are discussed.

Child↗
PubMedDate not supplied

Milia-like idiopathic calcinosis cutis.

Milia-like idiopathic calcinosis cutis is a rare entity. Only 17 cases have been reported so far. Two-thirds of these have been associated with Down syndrome. We report the fifth case occurring in a child without Down syndrome. Milia-like idiopathic calcinosis cutis has long been regarded as a peculiar subtype of idiopathic calcinosis cutis. The pathogenesis of the disorder remains unclear.

Adolescent↗
PubMedDate not supplied

Differential expression of the cancer-associated antigens T (Thomsen-Friedenreich) and Tn in primary and recurring squamous cell carcinomas of the skin.

The T (Thomsen-Friedenreich) antigen and its precursor, the Tn antigen, are complex mucin-type carbohydrate antigens, the expression of which seems to be correlated with prognosis in some human cancers. We studied comparatively the immunohistochemical expression of these antigens in a series of primary and locally recurring squamous cell carcinomas developing in the skin of immunosuppressed (organ-transplanted) patients. 10/26 tumours were completely unreactive for both antigens; among the remaining cases, 10/14 (71%) of recurring and 6/12 (50%) of primary tumours showed a higher expression of the precursor (Tn antigen) as compared with the T antigen. Since recurring tumours are more likely to spread metastatically, our results upheld the contention that a higher expression of the Tn antigen is correlated with a more aggressive course of cutaneous squamous cell carcinomas.

Antigens, Tumor-Associated, Carbohydrate↗
PubMedDate not supplied

Expression of the hair stem cell-specific keratin 15 in pilar tumors of the skin.

Keratin 15 (K15) was recently shown to be a specific marker of stem cells of the hair-follicle bulge. We studied the reactivity of an antibody to the CD8 antigen (C8/144B), recognizing K15, on 66 cutaneous tumors with known or alleged pilar differentiation, in order to assess its usefulness in the diagnosis of this group of tumors. 2/2 basal cell nevi, 5/8 trichoepitheliomas and 1/3 trichofolliculomas showed substantial reactivity. Much weaker reactivity was observed in cases of trichilemmal tumors (trichilemmomas and trichilemmal cysts); by contrast, all cases of pilomatricomas, basal cell carcinomas and epidermoid cysts were completely unreactive. These results are in keeping with the admitted differentiation of the tumors studied, and suggest further that basal cell carcinomas do not differentiate towards hair bulge cells. From a practical point of view, immunostaining for K15 seems to be an additional useful adjunct for the differential diagnosis between basal cell carcinoma and trichoepithelioma.

Antibodies, Monoclonal↗
PubMedDate not supplied

Expression of basement membrane antigens and matrix metalloproteinases 2 and 9 in cutaneous basal and squamous cell carcinomas.

BACKGROUND: Basement membrane (BM) antigens and matrix metalloproteinases (MMP) are involved in tumor invasion and metastasis. Basal (BCC) and squamous cell carcinomas (SCC) differ with respect to their biological behavior since the former are only locally aggressive whereas the latter have a metastatic potential. MATERIALS AND METHODS: We studied the immunohistochemical expression of several BM antigens and of MMP2 and MMP9, in 13 BCC, 13 SCC, and 8 in situ skin carcinomas. RESULTS: The expression of most BM antigens was reduced in the tumors in comparison with normal skin. Hemidesmosome- and lamina lucida-associated antigens (plectin, NUT2, alpha 6/CD49f and laminin-5) were more decreased in BCC, whereas collagens type VII and IV were more decreased in SCC as compared with BCC; in BCC and SCC both collagens tended to be decreased on the leading edge of invasive tumor masses. In situ carcinomas showed a slightly diminished expression of alpha 6/CD49f integrin, plectin and NUT2. The expression of both MMP2 and MMP9 was increased in SCC as compared with BCC. CONCLUSION: Our findings further upheld the role of BM antigens and MMPs in the process of tumor aggressiveness. The reduced expression of collagen IV, combined with an increased expression of both MMP2 and MMP9 could account for the increased metastatic potential of SCC vs BCC through an increased invasion of the extracellular matrix and the vascular space.

Antigens, Neoplasm↗
PubMedDate not supplied

Expression of the CD10 antigen (neutral endopeptidase) by mesenchymal tumors of the skin.

BACKGROUND: The CD10 (or CALLA) antigen is a neutral endopeptidase expressed by a variety of non-hemopoietic cells, including fibroblasts in various tissues. So far little or conflicting data exist concerning the expression of CD10 in normal and pathologic skin. METHODS: We investigated the immunohistochemical expression of the CD10 antigen on formalin-fixed, paraffin-embedded tissue specimens of normal skin and 162 cutaneous proliferative lesions, mostly mesenchymal tumors. RESULTS: In normal skin CD10 immunoreactivity was found in periadnexal mesenchymal cells. In skin tumors, CD10+ cells were found mainly in dermatofibromas and, to a lesser extent, in Dermatofibrosarcoma protuberans and neurofibromas. Metastatic (and to a lesser extent primary) melanomas also occasionally expressed CD10. CONCLUSION: Our results show that the CD10 antigen is expressed by mesenchymal cells of normal human dermis, presumably encompassing a subset of CD34+ dermal dendrocytes and/or periadnexal fibroblasts. The CD10 antigen could be used as an adjunct to the diagnosis of some spindle-cell cutaneous tumors such as dermatofibromas and Dermatofibrosarcoma protuberans, but its value as a single marker is rather limited. The possible role of CD10 as a progression marker in melanoma is interesting and merits further study.

Antibodies, Neoplasm↗
PubMedDate not supplied

[Immunological and immunocytochemical studies of the inflammatory infiltrating cells of cutaneous tumors].

The identication of mononuclear cells extracted from various inflammatory infiltrates of cutaneous tumours has been investigated and the relative amount of B and T cells determinated according to various assays. It has been found that there were two different patterns of distribution of the cells in the infiltrates: one with a E/EAC ratio similar 5 (squamous and basalcell carcinomas), the other with a E/EAC ratio similar 1(malignant melanoma). The identification in situ of Ig-producing cells has been developed in the same tissues fixed in Bouin's solution. The relative frequency of these cells has been determinated and appears very low in the malignant melanoma.

Cell Movement↗