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Biomedical subjects

A Chung

Publications and source records attributed to A Chung.

113 records · Page 7Linked to original sources
PubMedDate not supplied

The effect of dihydroxy bile acids on intestinal secretion, cyclic nucleotides, and Na+-K+-ATPase.

The effects of dihydroxy bile acids on intestinal cyclic nucleotides, Na+-K+-ATPase, and net secretion, and of propranolol pretreatment on these actions were determined. Ileal and colonic loops were constructed in each of 12 rabbits, six of which were treated with propranolol preoperatively. In random order, normal saline, 6mM deoxycholic, chenodeoxycholic, or ursodeoxycholic acids were injected into the intestinal loops. Five hours after, net luminal secretion and mucosal adenylate cyclase, phosphodiesterase, cGMP, and Na+-K+-ATPase were determined. Deoxycholic and chenodeoxycholic acids each increased adenylate cyclase activity (< 0.01) and net secretion (p < 0.01), and decreased cGMP (p < 0.05). Ursodeoxycholic acid did not alter adenylate cyclase activity or secretion but increased cGMP (p < 0.05). Phosphodiesterase and Na+-K+-ATPase were unchanged. Propranolol reversed all of the bile acid effects. In conclusion, chenodeoxycholic and deoxycholic acid induce net intestinal secretion, probably via cAMP. Ursodeoxycholic acid does not affect cAMP but increases cGMP and does not promote net secretion.

Animals↗
PubMedDate not supplied

Correlation of peri-implant health and aspartate aminotransferase levels: a cross-sectional clinical study.

At present, there are no diagnostic tools that permit early detection of peri-implantitis. The purpose of this cross-sectional study was to evaluate the correlation of aspartate aminotransferase (AST) levels with traditional periodontal clinical parameters around dental implants, since AST has been associated with destruction of cardiac, hepatic, and periodontal tissues. Twenty healthy volunteers with 59 implants were recruited from the Harvard School of Dental Medicine clinics. Clinical parameters evaluated included: AST level, probing depth (mm), Gingival Index (0, 1, 2, or 3), and bleeding on probing (0 or 1). Utilizing the site or implant as the unit of measure, the authors found a statistically significant association of increased AST activity with positive bleeding on probing, increased probing depth, and increased Gingival Index. No statistical correlations were found between clinical indices and increased AST levels when the results were examined on an individual patient basis. This cross-sectional study was able to demonstrate a statistical correlation between diseased clinical periodontal parameters and elevated AST levels.

Aspartate Aminotransferases↗
PubMedDate not supplied

Solitary reticulum cell sarcoma of the uterine cervix with initial cytodiagnosis.

A minimally symptomatic elderly woman was discovered to have reticulum cell sarcoma involving the uterine cervix on the basis of cervico-vaginal smears taken in the absence of a visible mass lesion. The diagnosis was confirmed by biopsy, and subsequent clinical and operative staging revealed the tumor to be arising in and confined to the uterine cervix. The cytologic features of reticulum cell neoplasia are repetitive and highly characteristic irrespective of its site of origin.

Aged↗